Immune Surveillance by CD8αα+ Skin-Resident T Cells in Human Herpes Virus Infection Using cell-type-specific laser capture microdissection, transcriptional profiling and T-cell antigen receptor β-chain genotyping on sequential genital skin biopsies, investigators showed that CD8αα+ T cells are the dominant resident population of dermal-epidermal junction (DEJ) CD8+ T cells that persist at the site of previous herpes simplex virus 2 reactivation. CD8αα+ T cells located at the DEJ lack chemokine-receptor expression required for lymphocyte egress and recirculation, express gene signatures of T-cell activation and antiviral activity, and produce cytolytic granules during clinical and virological quiescent time periods. [Nature] Abstract | Press Release IL-2-Dependent Tuning of NK Cell Sensitivity for Target Cells Is Controlled by Regulatory T Cells The authors hypothesized whether regulatory T (T reg) cells are required to restrain NK cells, the third lymphocyte lineage, whose features combine innate and adaptive immune cell properties. Although depletion of Treg cells led to systemic fatal autoimmunity, NK cell tolerance and reactivity to strong activating self- and non-self-ligands remained largely intact. [J Exp Med] Abstract Plasmacytoid Dendritic Cells Promote Rotavirus-Induced Human and Murine B Cell Responses Human in vitro and murine in vivo models of rotavirus infection were used to delineate the role of primary plasmacytoid DCs in initiating B cell responses. [J Clin Invest] Full Article Forced miR-146a Expression Causes Autoimmune Lymphoproliferative Syndrome in Mice via Downregulation of Fas in Germinal Center B Cells To elucidate the function of microRNA (miR)-146a in vivo, researchers generated a transgenic mouse line overexpressing miR-146a. Starting at an early age, these transgenic mice developed spontaneous immune disorders mimicking human autoimmune lymphoproliferative syndrome with distinct manifestations, including enlarged spleens and lymph nodes, inflammatory infiltration in the livers and lungs, increased levels of double-negative T cells in peripheral blood, and increased serum IgG levels. [Blood] Abstract Peptide Library-Based Evaluation of T-Cell Receptor Breadth Detects Defects in Global and Regulatory Activation in Human Immunologic Diseases Using combinatorial peptide libraries, investigators functionally measured broad T-cell reactivity and observed impaired reactivity in established models of T-cell receptor repertoire restriction and in previously unrecognized disease contexts. By concurrently analyzing T-regulatory and T-effector cells, they showed strong functional correlation between these subsets in healthy individuals and, strikingly, that alterations of this balance are associated with T helper type 2-mediated disease in a lymphopenic setting. [Proc Natl Acad Sci USA] Abstract Regulatory T Cell-Derived IL-10 Ameliorates Crescentic GN Using IL-10 reporter mice, scientists detected IL-10-producing Foxp3+ T cells in the kidney, blood, and secondary lymphoid tissue in a mouse model of crescentic GN. Specific inactivation of Il10 in Foxp3+ regulatory T cells (Tregs) eliminated the ability of these cells to suppress renal and systemic production of IFNγ and IL-17; these IL-10-deficient Tregs lost their capacity to attenuate renal tissue injury. [J Am Soc Nephrol] Abstract TIE-2 and VEGFR Kinase Activities Drive TIE-2-Expressing Monocytes Immunosuppressive Function in Human Breast Tumors The authors investigated the changes in TIE-2-expressing monocytes (TEM) immunosuppressive activity and gene expression in response to specific kinase inhibitors of TIE-2 and VEGFR. The ability of tumor TEM to suppress tumor-specific T cell response mediated by tumor dendritic cells was measured in vitro. [Clin Cancer Res] Abstract Engineered Regulatory T Cells Coexpressing MHC Class II: Peptide Complexes Are Efficient Inhibitors of Autoimmune T Cell Function and Prevent the Development of Autoimmune Arthritis Using a retroviral expression system encoding Foxp3 and HLA-DR1 covalently linked to the immunodominant peptide of the autoantigen type II collagen (DR1-CII), naive T cells were engineered to become regulatory T cells that express DR1-CII complexes on their surface. [J Immunol] Abstract Roles of Adipocytes and Fibroblasts in Activation of the Alternative Pathway of Complement in Inflammatory Arthritis in Mice Results demonstrated that pathogenic activation of the alternative pathway (AP) can occur in the joint through immune complexes adherent to cartilage and the local production of necessary AP proteins by adipocytes and fibroblast-like synoviocytes. [J Immunol] Abstract | Press Release The Immunologically Active Oligosaccharides Isolated from Wheatgrass Modulate Monocytes via Toll-Like Receptor-2 Signaling Wheatgrass-derived oligosaccharides (WG-PS3) were isolated and found to induce CD69 and Th1 cytokine expression in human peripheral blood mononuclear cells. In particular, WG-PS3 directly activated the purified monocytes by inducing the expression of CD69, CD80, CD86, IL-12, and TNF-α but affected NK and T cells only in the presence of monocytes. [J Biol Chem] Abstract | Full Article Don’t forget to subscribe to our sister publications: Human Immunology News and Immunology of Infectious Disease News! |