Immune Regulation News Volume 6.30 | Aug 15 2014

Role of Tyk-2 in Th9 and Th17 Cells in Allergic Asthma
In a murine model of allergic asthma, researchers found that Tyk-2^(−/−) asthmatic mice have induced peribronchial collagen deposition, mucosal type mast cells in the lung, interferon-regulatory factor 4 and hyperproliferative lung Th2 CD4⁺ effector T cells over-expressing IL-3, IL-4, IL-5, IL-10 and IL-13. [Sci Rep] Full Article

Brain Antigen Targeted in Paraneoplastic Neurologic Disease Limits Neuronal Autoimmunity but Not Cancer Rejection by Adoptively Transferred T Cells
In a C57BL/6 mouse model, central nervous system (CNS) antigen expression limited antigen-specific CD4⁺ and CD8⁺ T-cell expansion. CNS antigen expression did not limit tumor rejection by adoptively transferred transgenic T cells but did limit the generation of a memory population that could be expanded upon secondary challenge in vivo. [Eur J Immunol] Abstract

DRB1*0402 May Influence Arthritis by Promoting Naive CD4⁺ T-Cell Differentiation in to Regulatory T Cells
HLA-DRB1*0401 expression in humans has been associated with a predisposition to developing rheumatoid arthritis and collagen-induced arthritis, while HLA-DRB1*0402 is not associated with susceptibility. Investigators determined if mice transgenic for human *0401 have a CD4⁺ T-cell repertoire that predetermines pro-inflammatory cytokine production. [Eur J Immunol] Abstract

Systemic CD8⁺ T Cell-Mediated Tumoricidal Effects by Intratumoral Treatment of Oncolytic Herpes Simplex Virus with the Agonistic Monoclonal Antibody for Murine Glucocorticoid-Induced Tumor Necrosis Factor Receptor
Investigators examined the tumoricidal effects of oncolytic HF10, a naturally occurring mutant of herpes simplex virus type-1, combined with an agonistic DTA-1 monoclonal antibody specific for the glucocorticoid-induced tumor necrosis factor receptor. An accumulation of CD8⁺ T cells, including tumor- and herpes simplex virus type-1-specific populations, and a decrease in the number of CD4⁺ Foxp3⁺ T regulatory cells were seen in both HF10- and DTA-1-treated tumors. [PLoS One] Full Article

CD4⁺CD25⁺ Regulatory T Cells Are Not Required for Mesenchymal Stem Cell Function in Fully MHC-Mismatched Mouse Cardiac Transplantation
By using C57BL/6 mouse mesenchymal stem cells (MSCs) as donor-derived or recipient-derived or as third-party MSCs, scientists discovered that MSCs suppressed CD4⁺ T cell proliferation and prolonged mouse cardiac allograft survival in a dose-dependent and non-major histocompatibility complex (MHC)-restricted manner. [Cell Tissue Res] Abstract

Ursolic Acid Ameliorates Autoimmune Arthritis via Suppression of Th17 and B Cell Differentiation
Scientists examined the effects of ursolic acid (UA) on collagen-induced arthritis (CIA) in mice, and identified the mechanisms underlying the effects. UA treatment significantly reduced the incidence and severity of CIA-induced arthritis, accompanied by decreased expression of proinflammatory cytokines and oxidative stress markers in arthritic joints. [Acta Pharmacol Sin] Full Article

The Injury-Induced Myokine Insulin-Like 6 Is Protective in Experimental Autoimmune Myositis
Researchers analyzed the role of insulin-like 6 (Insl6) in experimental autoimmune myositis. Insl6 deficiency in mice led to a worsened myositis phenotype including increased infiltration of CD4 and CD8 T cells and the elevated expression of inflammatory cytokines. [Skelet Muscle] Abstract | Full Article

Subscribe to our sister publications:
Human Immunology News and Immunology of Infectious Disease News!

Visit our reviews page to see a complete list of reviews in the immune regulation research field.

23andMe Announces Agreement with Pfizer Inc. to Research Genetics of Ulcerative Colitis and Crohn’s Disease
23andMe announced an agreement with Pfizer Inc. in which the companies will aim to enroll 10,000 people with Inflammatory Bowel Disease (IBD) in a research initiative designed to explore the genetic factors associated with the onset, progression, severity and response to treatments for IBD. [23andMe, Inc.] Press Release

From our sponsor: Free mouse hematopoietic progenitors wallchart. Request your copy.

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Visit our events page to see a complete list of events in the immune regulation community.

NEW Postdoctoral Research Assistant – Cardiovascular Inflammation (University of Oxford)

PhD Position – Development and Regulation of Innate Immunity (Lund University)

Assistant Editor – Nature Biotechnology (Nature Publishing Group)

Postdoctoral Position – Macrophages Functions (Cochin Institute)

PhD Studentship – Regulation of Metabolism and Inflammation in Innate Immune Cells (Goethe-University Frankfurt)

PhD Studentship – Cancer Immunology (Cardiff University)

Postdoctoral Research Scientist – Virology (Cardiff University)

Postdoctoral Position – Human Heart Transplantation Immunology (Columbia University)

Principal Investigator Positions – Systems & Synthetic Biology (Institute for Research in Immunology and Cancer)

Scientist – Recombinant Molecules and Antibodies (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Recruit Top Talent: Reach more than 50,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.