The Ion Channel TRPV1 Regulates the Activation and Proinflammatory Properties of CD4+ T Cells Scientists found that TRPV1 was functionally expressed in CD4+ T cells, where it acted as a non-store-operated Ca2+ channel and contributed to T cell antigen receptor (TCR)-induced Ca2+ influx, TCR signaling and T cell activation. In models of T cell-mediated colitis, TRPV1 promoted colitogenic T cell responses and intestinal inflammation. [Nat Immunol] Abstract | Press Release Rhinovirus-Induced IL-25 in Asthma Exacerbation Drives Type 2 Immunity and Allergic Pulmonary Inflammation Investigators examined whether rhinoviruses (RV)-induced interleukin (IL)-25 could contribute to asthma exacerbations. Blockade of the IL-25 receptor reduced many RV-induced exacerbation-specific responses including type 2 cytokine expression, mucus production, and recruitment of eosinophils, neutrophils, basophils, and T and non-T type 2 cells. [Sci Transl Med] Abstract | Press Release NK1.1+ CD8+ T Cells Escape TGF-β Control and Contribute to Early Microbial Pathogen Response Investigators report that an effector CD8+ T-cell population that expresses the marker ​NK1.1 undergoes delayed contraction and sustains early anti-microbial protection. ​NK1.1+ CD8+ T cells are derived from CD8+ T cells during priming, and their differentiation is inhibited by transforming growth factor-β signaling. [Nat Commun] Abstract NAD+ Protects against EAE by Regulating ​CD4+ T-Cell Differentiation Investigators show that ​nicotinamide adenine dinucleotide (​NAD+) blocks experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, by inducing immune homeostasis through ​ CD4+​IFNγ+​IL-10+ T cells and reverses disease progression by restoring tissue integrity via remyelination and neuroregeneration. [Nat Commun] Full Article | Press Release Acquired Resistance to Fractionated Radiotherapy Can Be Overcome by Concurrent PD-L1 Blockade Fractionated radiotherapy delivered in combination with αPD-1 or αPD-L1 mAbs generated efficacious CD8+ T-cell responses that improved local tumor control, long-term survival, and protection against tumor rechallenge. These favorable outcomes were associated with induction of a tumor antigen-specific memory immune response. [Cancer Res] Abstract | Press Release NF-κB Functions in Tumor Initiation by Suppressing the Surveillance of Both Innate and Adaptive Immune Cells Scientists demonstrate that, following immortalization, p65 switches to an oncogene by counteracting the surveillance properties of immune cells. NF-κB exerts this effect by protecting transformed cells against macrophage-derived proapoptotic factors, tumor necrosis factor, and nitric oxide. [Cell Rep] Full Article | Graphical Abstract | Press Release The Bullseye Synapse Formed between CD4+ T-Cells and Staphylococcal Enterotoxin B-Pulsed Dendritic Cells Is a Suppressive Synapse in T-Cell Response Researchers found that the bullseye immunological synapse (IS), one type of IS at the interface of CD4+ T cells and staphylococcal enterotoxin B-pulsed dendritic cells, suppressed CD4+ T-cell activation, whereas multifocal IS, another synapse type, stimulated CD4+ T-cell activation. [Immunol Cell Biol] Abstract Overexpression of Jagged-1 Combined with Blockade of CD40 Pathway Prolongs Allograft Survival Scientists investigated whether blockade of the CD40 pathway could enhance the immune tolerance induced by dendritic cell 2.4 cells modified to express Jagged-1 in heart transplantation. The therapy specifically inhibited the immune response, induced alloantigen-specific T-cell hyporesponsiveness, upregulated transforming growth factor-β synthesis and increased the population of regulatory T cells driven by Jagged-1-Notch activation. [Immunol Cell Biol] Abstract Intramuscular Delivery of Heterodimeric IL-15 DNA in Macaques Produces Systemic Levels of Bioactive Cytokine Inducing Proliferation of NK and T Cells Investigators have generated DNA vectors expressing the heterodimeric interleukin (IL)-15 by optimizing mRNA expression and protein trafficking. Administration of DNAs expressing heterodimeric IL-15 resulted in an increased frequency of NK and T cells undergoing proliferation in peripheral blood. [Gene Ther] Full Article Subscribe to our sister publications: Human Immunology News and Immunology of Infectious Disease News! |