Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity Across multiple mouse tumor models and human tumor biopsies, scientists have delineated the intratumoral dendritic cell (DC) populations as distinct from macrophage populations. Within these, CD103+ DCs are extremely sparse and yet remarkably capable cytotoxic T cell stimulators. [Cancer Cell] Abstract | Graphical Abstract | Press Release miR-155 Promotes T Follicular Helper Cell Accumulation during Chronic, Low-Grade Inflammation Upon analyzing lymphocytes from inflamed versus healthy middle-aged mice, researchers found elevated numbers of T follicular helper cells, germinal center B cells, and autoantibodies, all occurring in a miR-155-dependent manner. [Immunity] Abstract A Minor Subset of Batf3-Dependent Antigen-Presenting Cells in Islets of Langerhans Is Essential for the Development of Autoimmune Diabetes Investigators found that the islets of Langerhans in young nonobese diabetic (NOD) mice contained two antigen-presenting cell populations: a major macrophage and a minor CD103+ dendritic cell (DC) population. In order to examine the role of the CD103+ DCs in diabetes, they examined Batf3-deficient NOD mice that lacked the CD103+ DCs in islets and pancreatic lymph nodes. [Immunity] Abstract | Graphical Abstract Regulatory T Cells Suppress Muscle Inflammation and Injury in Muscular Dystrophy Investigators examined the hypothesis that regulatory T cells (Tregs) modulate muscle injury and inflammation in the mdx mouse model of Duchenne muscular dystrophy. Although Tregs were largely absent in the muscle of wild-type mice and normal human muscle, they were present in necrotic lesions, displayed an activated phenotype, and showed increased expression of interleukin-10 in dystrophic muscle from mdx mice. [Sci Transl Med] Abstract | Press Release MicroRNA-Mediated Regulation of mTOR Complex Components Facilitates Discrimination between Activation and Anergy in CD4 T Cells Researchers investigated whether microRNAs affect the interpretation of T cell receptor signaling. They found that Dicer-deficient CD4 T cells fail to correctly discriminate between activating and anergy-inducing stimuli and produce IL-2 in the absence of co-stimulation. [J Exp Med] Abstract ​Interleukin-1α Released from HSV-1-Infected Keratinocytes Acts as a Functional Alarmin in the Skin The authors report that herpes simplex virus-1 (HSV-1)-infected keratinocytes actively release the also pro-inflammatory ​interleukin (IL)-1α, preserving the ability of infected cells to signal danger to the surrounding tissue. In vivo recruitment of leukocytes to early HSV-1 microinfection sites within the epidermis is dependent upon IL-1 signaling. [Nat Commun] Abstract TLR-Dependent Phagosome Tubulation in Dendritic Cells Promotes Phagosome Cross-Talk to Optimize MHC-II Antigen Presentation Investigators show that phagosomal tubules in dendritic cells are functionally distinct from those that emerge from lysosomes and are unique adaptations of the phagocytic machinery that facilitate cargo exchange and antigen presentation among Toll-like receptor (TLR)-signaling phagosomes. [Proc Natl Acad Sci USA] Abstract CD8 T Cells in Innate Immune Responses: Using STAT4-Dependent but Antigen-Independent Pathways to Gamma Interferon during Viral Infection Primary infections of mice with lymphocytic choriomeningitis virus (LCMV) demonstrate that although the elicited antigen-specific CD8 T cells acquired signal transducer and activator of transcription 4 (STAT4)-dependent innate cytokine responsiveness for interferon (IFN)-γ and CD25 induction ex vivo, T cell receptor stimulation induced these through STAT4-independent pathways. During secondary infections, LCMV-immune CD8 T cells had STAT4-dependent IFN-γ expression at times of innate cytokine induction but subsequently expanded through STAT4-independent pathways. [mBio] Full Article | Press Release Subscribe to our sister publications: Human Immunology News and Immunology of Infectious Disease News! |