Immune Regulation News Volume 7.05 | Feb 13 2015

Immature Myeloid Cells Directly Contribute to Skin Tumor Development by Recruiting IL-17-Producing CD4⁺ T Cells
To identify the direct role of CD33⁺S100A9⁺ cells in tumor development, investigators used S100A9 transgenic mice to create the conditions for topical accumulation of these cells in the skin in the absence of infection or tissue damage. [J Exp Med] Abstract | Press Release

Imaging Regulatory T Cell Dynamics and ​CTLA4-Mediated Suppression of T Cell Priming
​Foxp3⁺ regulatory T cells (Tregs) are identified as two non-overlapping populations in the T-zone and follicular regions of the lymph node. In the T-zone, Tregs migrate more rapidly than conventional T cells (Tconv), extend longer processes and interact with resident dendritic cells and Tconv. [Nat Commun] Abstract

Suppression of Systemic Autoimmunity by the Innate Immune Adaptor STING
Investigators report that stimulator of interferon genes (STING) potently suppresses inflammation in a model of systemic lupus erythematosus. STING-deficient macrophages failed to express negative regulators of immune activation and thus were hyperresponsive to TLR ligands, producing abnormally high levels of proinflammatory cytokines. [Proc Natl Acad Sci USA] Abstract

PTEN Regulates Natural Killer Cell Trafficking In Vivo
Scientists used a natural killer (NK) cell-specific phosphatase and tensin homolog (PTEN)-deletion mouse model to define the ramifications of intrinsic NK cell PTEN loss in vivo. They investigated the ability of PTEN-deficient NK cells to traffic to a site of tumor challenge. [Proc Natl Acad Sci USA] Abstract

Heme Oxygenase-1 Regulates Myeloid Cell Trafficking in AKI
Researchers investigated whether heme oxygenase-1 expression, which is protective in ischemia-reperfusion injury, regulates trafficking of myeloid-derived immune cells in the kidney. [J Am Soc Nephrol]
Abstract | Press Release

Immunomodulation of Selective Naive T Cell Functions by p110δ Inactivation Improves the Outcome of Mismatched Cell Transplantation
In a mouse model of fully mismatched hematopoietic cell transplantation, scientists show that genetic inactivation of p110δ in T cells leads to milder graft versus host disease, whereas graft versus leukemia is preserved. [Cell Rep] Full Article | Graphical Abstract

Subdominant H60 Antigen-Specific CD8 T-Cell Response Precedes Dominant H4 Antigen-Specific Response during the Initial Phase of Allogenic Skin Graft Rejection
To understand the mechanism underlying the subdominance of H60 during allogeneic skin transplantation, scientists investigated the dynamics of the H60-specific CD8 T cells in B6 mice transplanted with allogeneic BALB.B tail skin. [Exp Mol Med] Full Article

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Understanding of Molecular Mechanisms in Natural Killer Cell Therapy
Although immune cells can suppress cancer cell growth, cancer cells can evade immune cell attack via immune escape mechanisms. The authors discuss the overall procedures and strategies of NK cell therapy against cancer. [Exp Mol Med] Full Article

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Heat Biologics Presents Positive Preclinical Data on a Novel Approach to Combination Immunotherapy
Heat Biologics, Inc. announced data demonstrating the incorporation of T-cell costimulatory fusion proteins into Heat’s gp96-Ig vaccine platform. [Press release from Heat Biologics discussing research presented at the Keystone Tumor Immunology Symposium, Banff] Press Release

Biothera Immunotherapy Binds to Multiple Immune Cell Receptors to Kill Cancer
Biothera’s late stage cancer immunotherapy drug binds to multiple innate immune cell receptors to exert enhanced cytotoxicity against tumor cells. [Press release from Biothera discussing research presented at the Keystone Tumor Immunology Symposium, Banff] Press Release

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Juno Therapeutics Establishes Manufacturing Presence in Washington State
Juno Therapeutics, Inc. announced that it has entered into a lease agreement for a facility in Bothell, Washington to manufacture the company’s cell therapy products. [Juno Therapeutics, Inc.] Press Release

Panacea Pharmaceuticals Engages Accelovance for Clinical Development of Its Novel Nanoparticle-Based Therapeutic Cancer Vaccine
Panacea Pharmaceuticals, Inc. and Accelovance Inc. announced the establishment of a clinical development services agreement to develop and advance Panacea’s oncology immunotherapy pipeline. [Panacea Pharmaceuticals, Inc. (PR Newswire Association LLC)] Press Release

Advaxis Forms Clinical Trial Collaboration with Incyte to Evaluate Investigational Combination of Two Novel Cancer Immunotherapies for Early Stage Cervical Cancer
Advaxis, Inc. has entered into a clinical trial collaboration agreement with Incyte Corporation to evaluate the combination of Advaxis’s Lm-LLO cancer immunotherapy, ADXS-HPV, with Incyte’s investigational oral indoleamine 2,3-dioxygenase 1 inhibitor, epacadostat. [Advaxis, Inc.] Press Release

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Scientist – Recombinant Molecules and Antibodies (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Director – Vector Production (Sangamo BioSciences, Inc.)

Senior Process Development Engineer (Sangamo BioSciences, Inc.)

Assistant/Associate Professor – Gastroenterology (North Carolina State University College of Veterinary Medicine)

Postdoctoral Position – Immunology Animal Models (The Technical University of Denmark)

Postdoctoral Position – Inflammatory Bowel Disease (The Technical University of Denmark)

Postdoctoral Fellowship – CNS Inflammation (Rutgers University)

Senior Scientist – Immuno-Oncology (Merus B.V.)

Postdoctoral Position – HIV and Ebolavirus (University of Missouri)

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