Enrichment and Expansion with Nanoscale Artificial Antigen Presenting Cells for Adoptive Immunotherapy Researchers developed an enrichment + expansion strategy using paramagnetic, nanoscale artificial antigen presenting cells to rapidly expand tumor-specific T cells from rare naïve precursors and predicted neo-epitope responses. [ACS Nano] Abstract | Graphical Abstract | Press Release Phosphorylation Status Determines the Opposing Functions of Smad2/Smad3 as STAT3 Cofactors in TH17 Differentiation Investigators showed that the highly homologous transforming growth factor-β receptor-regulated Smads: Smad2 and Smad3 oppositely modify STAT3-induced transcription of interleukin-17A and retinoic acid receptor-related orphan nuclear receptor, RORγt encoded by Rorc, by acting as a co-activator and co-repressor of STAT3, respectively. [Nat Commun] Full Article MicroRNA-31 Negatively Regulates Peripherally Derived Regulatory T-Cell Generation by Repressing Retinoic Acid-Inducible Protein 3 Investigators showed that T-cell receptor signaling induces microRNA (miR)-31, which negatively regulates peripherally derived regulatory T (pTreg)-cell generation. miR-31 conditional deletion results in enhanced induction of pTreg cells, and decreased severity of experimental autoimmune encephalomyelitis. [Nat Commun] Full Article Adiponectin Regulates Psoriasiform Skin Inflammation by Suppressing IL-17 Production from γδ-T Cells Scientists demonstrated that adiponectin regulates skin inflammation, especially IL-17-related psoriasiform dermatitis. Mice with adiponectin deficiency showed severe psoriasiform skin inflammation with enhanced infiltration of IL-17-producing dermal Vγ4+γδ-T cells. [Nat Commun] Abstract Multiplex Genome Edited T-Cell Manufacturing Platform For “Off-The-Shelf” Adoptive T-Cell Immunotherapies Researchers used a transcription activator-like effector nuclease-mediated editing approach to develop a process for the large-scale manufacturing of T-cells deficient in expression of both their T-cell receptor and CD52, a protein targeted by alemtuzumab, a chemotherapeutic agent. [Cancer Res] Abstract | Press Release Regulatory B Cells Preferentially Accumulate in Tumor-Draining Lymph Nodes and Promote Tumor Growth Investigators showed that phenotypic characterization of lymphocytes in mice bearing B16-F10 melanomas identifies preferential accumulation of T2-MZP B cells in the tumor-draining popliteal lymph. [Sci Rep] Full Article Peripherally Induced Tolerance Depends on Peripheral Regulatory T Cells that Require Hopx To Inhibit Intrinsic IL-2 Expression The authors report that homeodomain-only protein (Hopx)+ peripheral regulatory T cells converted by dendritic cells from Hopx-T cells are indispensible to sustain tolerance that prevents autoimmune responses directed at self-Ags during experimental acute encephalomyelitis. [J Immunol] Abstract CCR4 Controls the Suppressive Effects of Regulatory T Cells on Early and Late Events during Severe Sepsis Scientists investigated the role of CCR4, the CCL17/CCL22 chemokine receptor, in the innate and acquired immune responses during severe sepsis and the role of regulatory T cells in effecting the outcome. [PLoS One] Full Article Don’t forget to subscribe to Human Immunology News and Immunology of Infectious Disease News! |