Immune Regulation News Volume 7.33 | Sep 4 2015

IL-36γ Transforms the Tumor Microenvironment and Promotes Type 1 Lymphocyte-Mediated Antitumor Immune Responses
Scientists found that IL-36γ stimulated CD8⁺ T cells, NK cells, and γδ T cells synergistically with TCR signaling and/or IL-12. Importantly, IL-36γ exerted profound antitumor effects in vivo and transformed the tumor microenvironment in favor of tumor eradication. [Cancer Cell] Abstract | Graphical Abstract

The Transcription Factor ATF7 Mediates Lipopolysaccharide-Induced Epigenetic Changes in Macrophages Involved in Innate Immunological Memory
Researchers identified an important role for the stress-response transcription factor ATF7 in innate immunological memory. ATF7 suppressed a group of genes encoding factors involved in innate immunity in macrophages by recruiting the histone H3K9 dimethyltransferase G9a. [Nat Immunol] Abstract | Press Release

Double-Negative αβ T Cells Are Early Responders to AKI and Are Found in Human Kidney
Scientists phenotypically and functionally characterized murine kidney CD4⁻CD8⁻ (double-negative) T cells in the steady state and in response to ischemia-reperfusion injury. [J Am Soc Nephrol] Abstract

Triglyceride-Rich Lipoproteins Modulate the Distribution and Extravasation of Ly6C/Gr1^low Monocytes
The authors report that in the presence of elevated levels of triglyceride-rich lipoproteins, induced by administration of poloxamer 407, the blood numbers of non-classical Ly6C/Gr1^low monocytes drop, while the number of bone marrow progenitors remains similar. [Cell Rep]
Full Article | Graphical Abstract | Press Release

Efficacy of Systemic Adoptive Transfer Immunotherapy Targeting NY-ESO-1 for Glioblastoma
Investigators utilized human glioblastoma cell cultures to induce expression of New York–esophageal squamous cell carcinoma (NY-ESO-1) following in vitro treatment with the demethylating agent decitabine. They examined the in vivo application of this immune therapy using an intracranially implanted xenograft model for in situ T cell trafficking, survival, and tissue studies. [Neuro Oncol] Abstract | Press Release

Inhibition of FOXP3/NFAT Interaction Enhances T Cell Function after TCR Stimulation
Researchers found that a short synthetic peptide able to inhibit FOXP3/NFAT interaction impaired suppressor activity of conventional regulatory T cells in vitro. Specific inhibition of FOXP3/NFAT interaction with this inhibitory peptide revealed that FOXP3 downregulates NFAT-driven promoter activity of CD40L and IL-17. [J Immunol] Abstract

Plasma Phospholipid Transfer Protein (PLTP) Modulates Adaptive Immune Functions through Alternation of T Helper Cell Polarization
Scientists demonstrated that PLTP deficiency in mice has a profound effect on CD4⁺ Th0 cell polarization, with a shift towards the anti-inflammatory Th2 phenotype under both normal and pathological conditions. [Cell Mol Immunol] Abstract

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Yale Cancer Center Receives $11 Million from National Cancer Institute for Lung Cancer Research
Armed with an $11 million grant from the National Cancer Institute, Yale Cancer Center and Smilow Cancer Hospital at Yale-New Haven will launch a new research program in non-small cell lung cancer. Known as a Specialized Program of Research Excellence, or SPORE, the new research program harnesses the strengths of academic cancer centers by bringing together experts in oncology, immunobiology, pharmacology, molecular biology, pathology, epidemiology, and addiction science to collaborate on projects. [Yale University] Press Release

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Postdoctoral Position – Immunology/Vascular Biology/Cancerology (University of Toulouse)

Postdoctoral Position – Neuroimmunology (Brain and Spine Institute (ICM))

Postdoctoral Research Fellow – Development and Pathogenesis of Pancreatic Cancer (University College London)

Senior Research Technician (Qu Biologics Inc.)

Postdoctoral Fellow – Immunology (The Henry M. Jackson Foundation)

Harry Eagle Scholar Awards for Postdoctoral Candidates (Albert Einstein College of Medicine of Yeshiva University)

Postdoctoral Positions – Cancer Research (Rutgers University)

Research Associate – Cell Biology (Editas Medicine)

Senior Research Associate – CRISPR-Based Therapeutics (Editas Medicine)

Research Assistant – Immunotherapy for HIV Infection (California Institute of Technology)

PhD Studentship – Veterinary and Animal Sciences (University of Milan)

Postdoctoral Fellow – Immune Reconstitution in Hematopoietic Stem Cell Transplantation (Stanford University)

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