Immune Regulation News Volume 8.01 | Jan 15 2016

Conditioning of Naive CD4⁺ T Cells for Enhanced Peripheral Foxp3 Induction by Nonspecific Bystander Inflammation
Investigators showed that nonspecific bystander inflammation conditions naive CD4⁺ T cells for enhanced peripheral Foxp3 induction and reduced effector differentiation. This results in inhibition of immune responses in vivo via a Foxp3-dependent effect on antigen-specific naive CD4⁺ T cell precursors. [Nat Immunol] Abstract

Enhanced Efferocytosis by Dendritic Cells Underlies Memory T-Cell Expansion and Susceptibility to Autoimmune Disease in CD300f-Deficient Mice
Scientists showed that, in contrast to CD300f function in macrophages, its expression inhibits efferocytosis by DC, and its deficiency leads to enhanced antigen processing and T-cell priming by these DC. [Cell Death Differ] Abstract

TRAIL-Coated Leukocytes that Prevent the Bloodborne Metastasis of Prostate Cancer
Scientists demonstrated an approach using nanoscale liposomes conjugated with E-selectin adhesion protein and Apo2L/TRAIL (TNF-related apoptosis-inducing ligand) apoptosis ligand that attach to the surface of leukocytes and rapidly clear viable cancer cells from circulating blood in the living mouse. [J Control Release] Abstract | Press Release | Video

TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-Pneumococcal Immunity
Researchers found that, in both humans and mice, circulating monocyte phenotype and function was altered with age due to increasing levels of tumor necrosis factor (TNF) in the circulation that occur as part of the aging process. [PLoS Pathog] Full Article | Press Release

Antitumor Activity of cGAMP via Stimulation of cGAS-cGAMP-STING-IRF3 Mediated Innate Immune Response
cGAMP enhances innate immune responses by inducing production of cytokines such as interferon-β, interferon-γ, and stimulating dendritic cells activation, which induces the cross-priming of CD8⁺ T cells. [Sci Rep] Full Article

Antigen-Specific T Cells Fully Conserve Antitumor Function following Cryopreservation
Scientists showed that cryopreservation fully conserves the differentiation potential of effector T cells, secretion of pro-inflammatory cytokines, cytotoxic function and does not impair the three-dimensional scanning motility of T cells or their capacity to infiltrate and reject tumors. [Immunol Cell Biol] Full Article

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GE Healthcare, FedDev Ontario Commit CAD $40 Million for New CCRM-Led Center to Solve Cell Therapy Manufacturing Challenges
GE Healthcare, the Federal Economic Development Agency for Southern Ontario (FedDev Ontario), and the Center for Commercialization of Regenerative Medicine (CCRM) are building a center for advanced therapeutic cell technologies in Toronto with an investment of $40 million from GE and FedDev Ontario. [Center for Commercialization of Regenerative Medicine] Press Release

New Study to Investigate How Good Antibodies Go Bad
New research, led by University at Buffalo oral biology researcher Jill Kramer, aims to re-examine whether IgM is pathogenic, or capable of causing disease. The research, “Analysis of the Source and Significance of IgM in Sjögren’s syndrome,” is one of several studies funded through a $16 million Clinical and Translational Science Award provided to UB from the National Institutes of Health. [University at Buffalo] Press Release

Researcher Gets Grant to Study How Immune System Can Prevent Inflammatory Bowel Diseases
A Georgia State University researcher has received a private grant of nearly $300,000 to investigate how the immune system can prevent inflammatory bowel disease. Benoit Chassaing, assistant professor in the Institute for Biomedical Sciences, will study how the adaptive immune system, which protects the body against pathogens, can control intestinal bacteria to prevent inflammation in the gut. [Georgia State University] Press Release

Gritstone Oncology Enters Into Exclusive Licensing Agreement and Collaboration with Memorial Sloan Kettering Cancer Center
Gritstone Oncology announced that the company has entered into an exclusive, worldwide licensing agreement and collaboration with Memorial Sloan Kettering Cancer Center. [Gritstone Oncology] Press Release

Immunotherapy for Epstein-Barr Related Lymphomas: First Health Canada Green Light Goes for Clinical Trial
Health Canada approved, for the first time in Canada, a clinical project for a Phase I study aimed at treating lymphomas associated with the Epstein-Barr virus (EBV) through adoptive cellular immunotherapy that is specific to EBV. [University of Montréal] Press Release

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