The Amino Acid Sensor GCN2 Controls Gut Inflammation by Inhibiting Inflammasome Activation Genetic deletion of Gcn2 in CD11c+ antigen presenting cells or intestinal epithelial cells resulted in enhanced intestinal inflammation and T helper 17 cell responses, owing to enhanced inflammasome activation and interleukin-1β production. [Nature] Abstract | Press Release The Maternal Microbiota Drives Early Postnatal Innate Immune Development By transiently colonizing pregnant female mice, scientists showed that the maternal microbiota shapes the immune system of the offspring. Gestational colonization increased intestinal group 3 innate lymphoid cells and F4/80+CD11c+ mononuclear cells in the pups. [Science] Abstract | Press Release C9orf72 Is Required for Proper Macrophage and Microglial Function in Mice C9orf72 expression was highest in myeloid cells, and the loss of C9orf72 led to lysosomal accumulation and altered immune responses in macrophages and microglia, with age-related neuroinflammation similar to C9orf72 amyotrophic lateral sclerosis (ALS) but not sporadic ALS human patient tissue. [Science] Abstract | Press Release Facilitating T Cell Infiltration in Tumor Microenvironment Overcomes Resistance to PD-L1 Blockade Researchers demonstrated that sufficient T cell infiltration in tumor tissues is a prerequisite for response to PD-L1 blockade. Targeting tumors with tumor necrosis factor superfamily member LIGHT activates lymphotoxin β-receptor signaling, leading to the production of chemokines that recruit massive numbers of T cells. [Cancer Cell] Abstract | Graphical Abstract | Press Release Type 1 Diabetes Vaccine Candidates Promote Human Foxp3+ Treg Induction in Humanized Mice Researchers identified HLA-DQ8-restricted insulin-specific CD4+ T cells and demonstrated efficient human insulin-specific Foxp3+ regulatory T cell (Treg)-induction upon subimmunogenic vaccination with strong agonistic insulin mimetopes in vivo. [Nat Commun] Full Article | Press Release Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells Scientists showed that saturated fatty acids (SFAs), when in excess, induce a unique transcriptional signature in both mouse and human macrophages that is enriched by a subset of ER stress markers, particularly IRE1α and many adaptive downstream target genes. SFAs also activate the NLRP3 inflammasome in macrophages, resulting in IL-1β secretion. [Cell Rep] Full Article | Graphical Abstract | Press Release The SNARE VAMP7 Regulates Exocytic Trafficking of Interleukin-12 in Dendritic Cells Investigators showed that intracellular interleukin (IL)-12 localizes in late endocytic vesicles marked by the SNARE VAMP7. Dendritic cells (DCs) from VAMP7-deficient mice are partially impaired in the multidirectional release of IL-12. Consistently, acquisition of effector functions is reduced in T cells stimulated by VAMP7-null DCs. [Cell Rep] Full Article | Graphical Abstract Antigen-Encoding Bone Marrow Terminates Islet-Directed Memory CD8+ T-Cell Responses to Alleviate Islet Transplant Rejection Researchers showed that transfer of bone marrow encoding cognate antigen directed to dendritic cells, under mild, immune-preserving conditions inactivates established memory CD8+ T-cell populations and generates a long-lived, antigen-specific tolerogenic environment. [Diabetes] Abstract IL-27 Suppresses Type 2 Immune Responses In Vivo via Direct Effects on Group 2 Innate Lymphoid Cells The authors provide compelling evidence that IL-27-signaling directly inhibits group 2 innate lymphoid cells responses and reveal a novel mechanism for negative regulation of the innate arm of type-2 immunity. [Mucosal Immunol] Abstract Don’t forget to subscribe to Human Immunology News and Immunology of Infectious Disease News! |