Immune Regulation News 8.19 May 27, 2016 | |
| |
TOP STORYAccess of Protective Antiviral Antibody to Neuronal Tissues Requires CD4 T-Cell Help The authors examined the mechanism by which antibodies gain access to neuronal tissues to control infection. Using a mouse model of genital herpes infection, they demonstrated that both antibodies and CD4 T cells are required to protect the host after immunization at a distal site. [Nature] Abstract | Press Release | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion Using a murine chronic virus that models human infections, scientists investigated the function of the adhesion molecule, P-selectin glycoprotein ligand-1 (PSGL-1), that is upregulated on responding T cells. [Immunity] Abstract | Graphical Abstract | Press Release CIS Is a Potent Checkpoint in NK Cell-Mediated Tumor Immunity Researchers identified cytokine-inducible SH2-containing protein (CIS, encoded by Cish) as a critical negative regulator of IL-15 signaling in natural killer (NK) cells. [Nat Immunol] Abstract | Press Release CD62L+ NKT Cells Have Prolonged Persistence and Antitumor Activity In Vivo Investigators demonstrated that antigen-induced expansion of primary natural killer T cells (NKTs) in vitro associates with the accumulation of a CD62L+ subset and exhaustion of CD62L– cells. [J Clin Invest] Full Article | Press Release T-Bet Is a Key Modulator of IL-23-Driven Pathogenic CD4+ T Cell Responses in the Intestine Scientists showed that T-bet expression by T cells is not required for the induction of colitis or the differentiation of pathogenic Th17 cells but modifies qualitative features of the IL-23-driven colitogenic response by negatively regulating IL-23R expression. [Nat Commun] Full Article Researchers showed that the gut epithelium of myelin oligodendrocyte glycoprotein(35-55)-specific T-cell receptor transgenic mice contains environmental stimuli-induced intraepithelial lymphocytes that inhibit experimental autoimmune encephalomyelitis on transfer. [Nat Commun] Full Article Atg5 Is Essential for the Development and Survival of Innate Lymphocytes Scientists demonstrated that Atg5, an essential component of the autophagy machinery, is required for the development of mature natural killer cells and group 1, 2, and 3 innate innate lymphoid cells. [Cell Rep] Full Article | Graphical Abstract Monoclonal Regulatory T Cells Provide Insights into T Cell Suppression Investigators made use of a T cell receptor transgenic, Rag−/− mouse expressing a Forkhead-Box-Protein P3 (Foxp3) transgene. This mouse provides a source of monoclonal CD4+ Foxp3+ T cells with a defined specificity. [Sci Rep] Full Article The role of donor CD47 in regulation of T-cell alloresponses is poorly understood. Researchers addressed this question by assessing OVA-specific immune responses in mice following hepatocyte transplantation from CD47-competent or -deficient OVA-transgenic donors. [Sci Rep] Full Article LAG-3 Confers a Competitive Disadvantage upon Antiviral CD8+ T Cell Responses Researchers performed a series of adoptive transfer experiments in mice to better understand the T cell–intrinsic functions of lymphocyte activation gene-3 in the regulation of CD8+ T cell responses. [J Immunol] Abstract Although inflammatory B cells contribute to experimental autoimmune encephalomyelitis (EAE)’s pathogenesis, treatment of EAE mice with myelin oligodendrocyte glycoprotein fused to reovirus protein σ1, but not OVA-pσ1, resulted in an influx of IL-10–producing B220+CD5+ B regulatory cells enabling regulatory T cells to recover their inhibitory activity, and in turn, leading to the rapid amelioration of EAE. [J Immunol] Abstract Subscribe to out sister publications: Human Immunology News & Immunology of Infectious Disease News. | |
| |
REVIEWSImmunometabolism of Regulatory T Cells Studies demonstrating the metabolic similarities of proliferating immune cells and cancer cells have helped give birth to the new field of immunometabolism, which focuses on how the cell-intrinsic metabolic properties of lymphocytes and macrophages can themselves dictate the fate and function of the cells and eventually shape an immune response. The authors focus on this aspect, particularly as it relates to regulatory T cells. [Nat Immunol] Abstract Visit our reviews page to see a complete list of reviews in the immune regulation research field.
| |
INDUSTRY NEWSTxCell SA announced that it has received authorization from European regulatory authorities to restart its Phase IIb, placebo-controlled clinical trial with lead product Ovasave® in patients with moderate to severe Crohn’s disease refractory to existing treatments. [TxCell SA] Press Release Genmab A/S announced that the European Commission has granted a conditional marketing authorization for first-in-class CD38 antibody DARZALEX®. [Genmab A/S] Press Release | |
From our sponsor: Learn how to isolate cells from whole blood in 25 minutes. Watch the video.
| |
POLICY NEWSOvertime Pay for Postdoctoral Scientists Is Welcome — But Could Mean Fewer Positions In a long-overdue revision of American overtime regulations, the Department of Labor explicitly included postdocs among those who are eligible for overtime pay if they earn less than $47,476 per year. [Nature News] Editorial
| |
EVENTSNEW 2nd Annual Cell & Gene Therapy Congress 2016 Visit our events page to see a complete list of events in the immune regulation community.
| |
JOB OPPORTUNITIESTechnical Sales Representative (STEMCELL Technologies Inc.) Research Technologist – T Cell Immunology (STEMCELL Technologies Inc.) Research Technologist – Cell Separation (STEMCELL Technologies Inc.) Scientist – Bioengineering (STEMCELL Technologies Inc.) Senior Scientist – Immunology and Cell Separation (STEMCELL Technologies Inc.) Postdoctoral Position – Transforming Growth Factor β on the Regulation of T Cell Response (Inserm) Postdoctoral Fellow – Immunology (New York University Medical Center) Faculty Positions – Microbiology and Immunology (National University of Singapore) PhD Positions – Cancer Research (German Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Immune Regulation News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|