Immune Regulation News Volume 8.23 | Jun 24 2016

TOP STORY

Unlocking Secrets of the Immune System Could Help Combat Colitis

Researchers identified interactions between immune system pathways which could improve the treatment of diseases such as inflammatory bowel disease, which affects millions of people worldwide. [Press release from The University of Queensland discussing online prepublication in Science] Press Release | Video | Abstract

(Ranked by impact factor of the journal)

Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

The authors established that abnormal self-antigens can serve as targets for tumor rejection. They developed a chimeric antigen receptor (CAR) that recognized cancer-associated Tn glycoform of MUC1, a neoantigen expressed in a variety of cancers. [Immunity] Full Article | Press Release

Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4⁺ T Cells

Researchers investigated metabolic mechanisms underlying the differentiation of IL-9-producing CD4⁺ T cells in allergic airway inflammation and cancerous tumors. [Immunity] Abstract | Graphical Abstract

Modeling Altered T-Cell Development with Human Induced Pluripotent Stem Cells from Patients with RAG1 Mutations and Distinct Immunological Phenotypes

Scientists used in vitro differentiation of human induced pluripotent stem cells generated from patients with different RAG1 mutations to assess T-cell development and T-cell receptor V(D)J recombination. [Blood] Abstract

TCR Repertoire Sequencing Identifies Synovial Treg Cell Clonotypes in the Bloodstream during Active Inflammation in Human Arthritis

Researchers compared regulatory T (Treg) cells of patients with juvenile idiopathic arthritis responding or not to therapy by using: T cell receptor (TCR) sequencing, to identify clonotypes shared between blood and synovial fluid; FOXP3 Treg cell-specific demethylated region DNA methylation assays, to investigate their stability and flow cytometry and suppression assays to probe their tolerogenic functions. [Ann Rheum Dis] Full Article

AKT Isoforms Modulate Th1-Like Treg Generation and Function in Human Autoimmune Disease

The authors describe the signaling events driving the generation of human T helper 1 (Th1)-regulatory T cells (Tregs). Using a genome-wide gene expression approach and pathway analysis, they identified the PI3K/AKT/Foxo1/3 signaling cascade as the major pathway involved in IFNγ secretion by human Tregs. [EMBO Rep] Abstract | Graphical Abstract

Deregulation of SOCS5 Suppresses Dendritic Cell Function in Chronic Lymphocytic Leukemia

To understand the molecular mechanism for this abnormality, researchers focused on signal transduction pathways that regulate the function of monocyte-derived dendritic cells. [Oncotarget] Full Article

E-Cigarette Use Results in Suppression of Immune and Inflammatory-Response Genes in Nasal Epithelial Cells Similar to Cigarette Smoke

Researchers conducted a clinical study collecting superficial nasal scrape biopsies, nasal lavage, urine, and serum from non-smokers, cigarette smokers and e-cigarette users and assessed them for changes in immune gene expression profiles. [Am J Physiol Lung Cell Mol Physiol] Abstract | Press Release

Enhanced Th1/Th17 Functions of CD161⁺ CD8⁺ T Cells in Mucosal Tissues of Rhesus Macaques

Investigators examined the phenotypic and functional characteristics of CD161⁺ T cells in peripheral blood, mucosal tissues and lymph nodes of rhesus macaques. [PLoS One] Full Article

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The Life Cycle of a T Cell after Vaccination – Where Does Immune Aging Strike?

The authors focus on T cell-intrinsic mechanisms that control how a T cell is activated, rapidly expands to differentiate into short-lived effector cells including follicular helper cells and into memory precursor cells and then mostly undergoes apoptosis with few cells surviving as long-lived memory T cells. [Clin Exp Immunol] Abstract | Full Article

Visit our reviews page to see a complete list of reviews in the immune regulation research field.

Baylor, Cell Medica Announce Groundbreaking Collaboration to Create Cellular Immunotherapy Products for Cancer Treatment

Baylor College of Medicine announced the launch of a landmark sponsored research collaboration, representing a significant milestone in its efforts to develop a new class of life-saving cancer therapy. Baylor has provided Cell Medica with an exclusive license to its proprietary natural killer T cell immunotherapy platform, five product candidates and an option to license future product candidates. [Baylor College of Medicine] Press Release

Celyad Treats First Patient in the Fourth Dose Level of Its NKR-2 Trial

Celyad announced the infusion of the first patient enrolled in the fourth dose level of its Phase I/IIa clinical trial. The study is evaluating the safety and feasibility of its NKR-2 T-cell therapy using T-cells with NKG2D receptor in cancer patients suffering from acute myeloid leukemia or multiple myeloma. [Celyad] Press Release

Cellectis Announces First Patient Treated in Phase I Trial of UCART19 in Pediatric Acute B Lymphoblastic Leukemia (B-ALL)

Cellectis announced that the first patient has been treated in the Phase I study of gene edited CAR T-cells (UCART)19 in pediatric acute B-ALL at the University College of London. [Cellectis] Press Release

Adaptimmune Receives Positive Opinion for Orphan Drug Designation in the European Union for SPEAR™ T-Cell Therapy Targeting NY-ESO for Treatment of Soft Tissue Sarcoma

Adaptimmune Therapeutics plc announced that the European Medicines Agency’s Committee for Orphan Medicinal Products has adopted a positive opinion recommending the company’s SPEAR™ T-cell therapy targeting NY-ESO for designation as an orphan medicinal product for the treatment of soft tissue sarcoma. [Adaptimmune Therapeutics plc] Press Release

Researchers Reeling as UK Votes to Leave EU

The United Kingdom’s vote to leave the European Union has plunged it into political and economic uncertainty — and left researchers worried over the future of their funding and collaborations, the UK’s participation in major European research programs, and the freedom of movement and employment status of thousands of scientists. [Nature News] Editorial

NEW World Stem Cell Summit 2016
December 6-9, 2016
West Palm Beach, United States

Visit our events page to see a complete list of events in the immune regulation community.

NEW Associate Director – T Cell Risk Management (Celgene Corporation)

Technical Sales Representative (STEMCELL Technologies Inc.)

Research Technologist – T Cell Immunology (STEMCELL Technologies Inc.)

Research Technologist – Cell Separation (STEMCELL Technologies Inc.)

Scientist – Bioengineering (STEMCELL Technologies Inc.)

Senior Scientist – Immunology and Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Immunology (Stanford University)

Research Post Doctoral Fellow – Molecular Immunology/Cell Signaling (Baylor Scott & White Health)

Research Associate – TNF Blockade Regulates of IL-10 (King’s College London)

Postdoctoral Scientist – Novel Immune Modulating Drugs (Celenlyx)

Postdoctoral/Senior Postdoctoral Fellow Positions – CD8 Biology, CD4 Plasticity, and T Cell Receptor Signaling (Georgia Cancer Center)

Postdoctoral Position – Transforming Growth Factor β on the Regulation of T Cell Response (Inserm)

Post Doctoral Research – Fellow Thymic and Immune Regeneration (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Immunology (New York University Medical Center)

Postdoctoral Position – Regulation of γδ T Cell Phenotype and Trafficking in Breast Cancer Metastasis (Cancer Research UK Beatson Institute)

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