Immune Regulation News 8.32 September 2, 2016 | |
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TOP STORYGlycosylation and Stabilization of Programmed Death Ligand-1 Suppresses T-Cell Activity Researchers showed that the immunosuppression activity of programmed death ligand-1 (PD-L1) is stringently modulated by ubiquitination and N-glycosylation. They showed that glycogen synthase kinase 3β interacts with PD-L1 and induces phosphorylation-dependent proteasome degradation of PD-L1 by β-TrCP. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Bach2-Batf Interactions Control Th2-Type Immune Response by Regulating the IL-4 Amplification Loop The authors demonstrated that Bach2 associates with Batf and binds to the regulatory regions of the Th2 cytokine gene loci. The Bach2–Batf complex antagonizes the recruitment of the Batf–Irf4 complex to AP-1 motifs and suppresses Th2 cytokine production. [Nat Commun] Full Article Scientists showed that the E3 ubiquitin ligase Hrd1 protected B cells from activation-induced cell death by degrading the death receptor Fas. Hrd1-null B cells exhibited high Fas expression during activation and rapidly underwent Fas-mediated apoptosis, which could be largely inhibited by FasL neutralization. [Proc Natl Acad Sci USA] Abstract | Full Article Immune Stimulatory Effects of Rapamycin Are Mediated by Stimulation of Antitumor γδ T Cells Scientists report evidence that rapamycin-mediated cancer protection relies upon stimulation of γδ T cells. In a well-established mouse model of carcinogen and inflammation-driven skin carcinogenesis, interferon-γ recruited γδ TCRmid T cells to the epidermis where rapamycin boosted their perforin-dependent antitumor properties. [Cancer Res] Abstract Researchers demonstrated that B cells induced a particular subset of regulatory T cells expressing programmed cell death 1, inducible costimulator, lymphocyte-activation gene 3, glucocorticoid-induced tumor necrosis factor receptor, and OX-40, did not express Foxp3. [Sci Rep] Full Article Scientists investigated the mechanism of action of L-pampo, a proprietary adjuvant composed of Toll-like receptor (TLR)1/2 and TLR3 ligands. L-pampo dramatically increased humoral immune responses against the tested target antigens, which was correlated with an increase in follicular helper T cells and the maintenance of antigen-specific CD4+ T cells. [Sci Rep] Full Article The authors hypothesized that extracellular CIRP promotes activation of T lymphocytes in the spleen during sepsis. They observed that mice subjected to sepsis by cecal ligation and puncture showed significantly higher expression of the early activation markers CD69 and CD25 at 20 hours on CD4+ splenic T cells, and significantly higher CD69 expression on CD8+ splenic T cells compared with sham-operated controls. [Cell Mol Immunol] Abstract Investigators report that IL-2–dependent regulatory T cells in the spleen compete for a limiting supply of paracrine IL-2 generated by autoreactive CD4+ T cells in response to MHC class II–restricted autoantigen activation by 33D1+CD11bint dendritic cells. [J Immunol] Abstract The authors aimed to determine whether altered peripheral regulatory T-cells and defined subsets, besides a broadened anti-citrullinated protein antibody response, may qualify as biomarkers for rheumatoid arthritis development in seropositive arthralgia patients. [PLoS One] Full Article Tissue-Specific Emergence of Regulatory and Intraepithelial T Cells from a Clonal T Cell Precursor The authors found that the peripheral Foxp3+ regulatory T cells (pTreg) T cell receptor did not inevitably predispose T cells to become pTreg but instead allowed for differentiation of noninflammatory CD4+CD8αα+ intraepithelial lymphocytes in the small intestine. [Sci Immunol] Abstract Subscribe to our sister publications: Human Immunology News & Immunology of Infectious Disease News. | |
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REVIEWSThe author covers the mucosal immune system of the gastrointestinal tract and the immunological mechanisms underlying IgE-mediated food allergy, as well as introduces cells recently identified to have a role in the hypersensitivity reaction to food allergens. [J Allergy Clin Immunol] Abstract Visit our reviews page to see a complete list of reviews in the immune regulation research field. | |
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SCIENCE NEWSSunesis Pharmaceuticals, Inc. announced that a poster detailing preliminary results from the company’s Phase IA study in healthy volunteers evaluating oral non-covalent BTK-inhibitor SNS-062 will be presented. [Press release from Sunesis Pharmaceuticals, Inc. discussing research to be presented at the European School of Haematology’s 2nd International Conference on New Concepts in B-Cell Malignancies] Press Release | |
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INDUSTRY NEWSAmgen and Boehringer Ingelheim announced that Amgen has acquired global development and commercial rights from Boehringer Ingelheim for BI 836909, a bispecific T cell engager (BiTE®) that targets B-cell maturation antigen, a potential target for multiple myeloma. BI 836909 is currently in Phase I studies. [Amgen Inc.] Press Release Amgen announced that the U.S. Food and Drug Administration (FDA) has approved the supplemental Biologics License Application for BLINCYTO® to include new data supporting the treatment of pediatric patients with Philadelphia chromosome-negative relapsed or refractory B-cell precursor acute lymphoblastic leukemia. [Amgen Inc.] Press Release | |
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POLICY NEWSWhistleblower Sues Duke, Claims Doctored Data Helped Win $200 Million in Grants On a Friday in March 2013, a researcher working in the lab of a prominent pulmonary scientist at Duke University in Durham, North Carolina, was arrested on charges of embezzlement. The researcher, biologist Erin Potts-Kant, later pled guilty to siphoning more than $25,000 from the Duke University Health System, buying merchandise from Amazon, Walmart, and Target—even faking receipts to legitimize her purchases. [ScienceInsider] Editorial Wanted: UK Science Czar. Generous Compensation. Not for the Faint-Hearted. Do you have a high scientific standing? A wide appreciation of different research disciplines? Fancy earning £300,000 ($400,000)? If so, the UK government has a job for you. [Nature News] Editorial London Super-Lab Opens under Cloud of Brexit The UK government and the Crick’s other funders have gambled £700 million (US$927 million) on the institute, in the hope that it will attract some of world’s brightest young biomedical researchers to Britain and catalyze a boom in the UK life-sciences economy. [Nature News] Editorial
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EVENTSNEW Cell & Gene Therapy Bioprocessing & Commercialization NEW Immunogenicity and Bioassay Summit 2016 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESTechnical Sales Representative (STEMCELL Technologies Inc.) Research Technologist – Cell Separation (STEMCELL Technologies Inc.) Senior Scientist – Immunology and Cell Separation (STEMCELL Technologies Inc.) Postdoctoral Fellow – Genomics and Human Immunity (The Jackson Laboratory) Postdoctoral Researcher – Translational Immunology (University of Eastern Finland) Faculty Position – Immunology (Vanderbilt University Medical Center) Postdoctoral Fellow – Mucosal Immunology (University of Utah) Postdoctoral Position – Tumor Immunology and T Cell Differentiation (University of Lausanne) Postdoctoral Research Scientist (National Taiwan University) Postdoctoral Position – Tumor Immunology (Roswell Park Cancer Institute) Postdoctoral Fellow – Cancer Biology and Cancer Immunology (Fox Chase Cancer Center) Postdoctoral Position – Immunology (Ludwig-Maximilians-Universität) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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