Immune Regulation News 8.37 October 7, 2016 | |
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TOP STORYIdentification of a Role for TRIM29 in the Control of Innate Immunity in the Respiratory Tract Investigators found that the E3 ubiquitin ligase TRIM29 was a selective regulator of the activation of alveolar macrophages, the expression of type I interferons and the production of proinflammatory cytokines in the lungs. [Nat Immunol] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Foxp3 and Toll-Like Receptor Signaling Balance Treg Cell Anabolic Metabolism for Suppression Scientists found that Toll-like receptor (TLR) signals that promote regulatory T cell (Treg cell) proliferation increased PI(3)K-Akt-mTORC1 signaling, glycolysis and expression of Glut1. However, TLR-induced mTORC1 signaling also impaired Treg cell suppressive capacity. [Nat Immunol] Abstract The authors investigated the recruitment, activation and inflammatory activity of T cells in deep vein thrombosis and its consequences for venous thrombus resolution. [Circ Res] Abstract Using peptide–MHC tetramers, scientists isolated rare specific Foxp3+ cells directly ex vivo from adult peripheral blood and defined their frequency and phenotype. They found that a proportion of circulating regulatory T cells (Tregs) recognize foreign antigens and the frequency of these cells are similar to that of self-reactive Tregs in the absence of cognate infection. [Proc Natl Acad Sci USA] Abstract | Full Article Researchers report that mTOR in CD4 T cells is essential for T follicular helper T (Tfh) differentiation. In Mtorf/f-Cd4Cre mice, both constitutive and inducible Tfh differentiation is severely impaired, leading to defective germinal center B cell formation and antibody production. [eLife] Abstract | Download Full Article Self-Antigen-Driven Thymic B Cell Class Switching Promotes T Cell Central Tolerance Scientists demonstrated that a large percentage of thymic B cells have undergone class switching intrathymically. Thymic B cell class switching requires cognate interaction with specific T cells. [Cell Rep] Full Article | Graphical Abstract Vaccination with inhibitor of differentiation 2 granulocyte-macrophage colony-stimulating factor–derived dendritic cells slowed the progression of melanoma tumors and enhanced animal survival, which was associated with an increased abundance of tumor-infiltrating interferon-γ–positive CD4+ effector and CD8+ cytotoxic T cells and a decreased number of tumor-infiltrating regulatory CD4+ T cells. [Sci Signal] Abstract IL-2 Variant Circumvents ICOS+ Regulatory T Cell Expansion and Promotes NK Cell Activation Investigators characterized the effect of a mutant form of IL-2, which preferentially binds to the lower affinity IL-2Rβγ with reduced binding to CD25, on T-regulatory cells, effector NK cells, and T-cell subsets. [Cancer Immunol Res] Abstract Aged mice developed increased corneal permeability, CD4+ T-cell infiltration, and conjunctival goblet cell loss. Aged mice have lacrimal gland (LG) atrophy with increased lymphocyte infiltration and inflammatory cytokine levels. An increase in the frequency of CD4+Foxp3+ T regulatory cells was observed with age in the cervical lymph node, spleen, and LG. [Mucosal Immunol] Abstract Researchers results revealed that PTEN could ameliorate experimental autoimmune arthritis by reducing STAT3 activity and Th17 differentiation. Systemic infusion of PTEN overexpression downregulated CIA severity. In addition, PTEN overexpression decreased the activation of T cells and modulated reciprocal differentiation of Th17 and Treg cells. [Sci Rep] Full Article The intracellular immune kinases RIPK1, TAK1, and AKT were selectively degraded by the Porphyromonas gingivalis lysine-specific gingipain in human endothelial cells, which correlated with dysregulated innate immune signaling. [Sci Rep] Abstract Subscribe to our sister publications: Human Immunology News & Immunology of Infectious Disease News. | |
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REVIEWSWrit Large: Genomic Dissection of the Effect of Cellular Environment on Immune Response The authors highlight some of the emerging principles on the role of dense regulatory circuitry, epigenetic memory, cell type fluidity, and reuse of regulatory modules in achieving and maintaining appropriate responses to a changing environment. [Science] Abstract Mouse Models in Oncoimmunology Mouse models of transplantable, carcinogen-induced or genetically engineered malignancies — each with their specific advantages and difficulties — have laid the foundations of oncoimmunology. [Nat Rev Cancer] Abstract Visit our reviews page to see a complete list of reviews in the immune regulation research field. | |
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SCIENCE NEWSOSE Immunotherapeutics SA will present in an oral session preclinical studies results for Effi-DEM, a new generation checkpoint inhibitor targeting myeloid derived suppressor cells and tumor associated macrophages. [Press release from OSE Immunotherapeutics SA discussing research to be presented at the Immune Checkpoint Inhibitors (ICI) Conference, Munich] Press Release | |
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INDUSTRY NEWSBristol-Myers Squibb Company and Nektar Therapeutics announced a new clinical collaboration to evaluate Bristol-Myers Squibb’s Opdivo with Nektar’s investigational medicine, NKTR-214, as a potential combination treatment regimen in five tumor types and seven potential indications. [Bristol-Myers Squibb Company] Press Release Six Researchers at UC San Diego Receive $5 Million from NIH for Transformative Research Four biologists, a nanoengineer and a biophysicist at UC San Diego received a total of more than $5 million in grants from the National Institutes of Health to pursue innovative and transformative research projects. [UC San Diego] Press Release Dr. Allen Eaves of STEMCELL Technologies Inc. Named EY Entrepreneur Of The Yearâ„¢ Pacific 2016 Dr. Allen Eaves, Chairman, President and Chief Executive Officer of STEMCELL Technologies, a global biotechnology company that supplies tools and services to enable life science research, is this year’s Entrepreneur Of The Year Pacific winner. [Ernst & Young (CNW Group Ltd.)] Press Release | |
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POLICY NEWSDramatic Twists Could Upend Patent Battle over CRISPR Genome-Editing Method The 9-month-old patent battle over CRISPR, a novel genome-editing tool that could have immense commercial value, has taken two surprising twists. Last week, attorneys for the Broad Institute in Cambridge, Massachusetts, one of the research organizations vying for CRISPR rights, submitted motions that could let it win even if it loses. [Science Insider] Editorial Brexit Government’s Anti-Immigration Stance Spooks UK Scientists UK scientists say they’re dismayed by their new government’s toughened stance on curbing immigration, including ideas to restrict the flow of foreign students and workers. [Nature News] Editorial
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EVENTSNEW Advances in Cell Engineering, Imaging and Screening Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Immunology (Klinikum der Universität München) NEW Faculty Positions – Immunology (Ohio State University) Research Technologist – Cell Separation (STEMCELL Technologies Inc.) Faculty Position – Immunogen Development and Evaluation (Fred Hutchinson Cancer Research Center) Research Associate – Cellular Therapy (California Institute for Biomedical Research) Director – Immunobiology and Microbial Pathogenesis (The Salk Institute for Biological Studies) Assistant Associate or Full Member – Cancer Immunology (Fred Hutchinson Cancer Research Center) Postdoctoral Opportunities – Immunology (Keck School of Medicine) Professor – Clinical Immunology (Lund University) Postdoctoral Fellow – Immunology (Icahn School of Medicine at Mount Sinai) Postdoctoral Fellow – Molecular Immunology (University of California, San Diego) Chair – Medical Biology (Masaryk University) Postdoctoral Fellow – Genomics and Human Immunity (The Jackson Laboratory) Faculty Position – Immunology (Vanderbilt University Medical Center) Postdoctoral Fellow – Mucosal Immunology (University of Utah) Postdoctoral Research Scientist (National Taiwan University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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