Immune Regulation News 9.04 February 3, 2017 | |
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TOP STORYDendritic Cell MST1 Inhibits Th17 Differentiation The authors investigated the role of dendritic cell (DC)-dependent T-cell differentiation in autoimmune and antifungal inflammation and find that mammalian sterile 20-like kinase 1 (MST1) signaling from DCs negatively regulates IL-17 producing-CD4+T helper cell (Th17) differentiation. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)ERBIN Deficiency Links STAT3 and TGF-β Pathway Defects with Atopy in Humans Researchers showed that STAT3 negatively regulates TGF-β signaling via ERBB2-interacting protein (ERBIN), a SMAD anchor for receptor activation and SMAD2/3 binding protein. [J Exp Med] Abstract cGAS Is Essential for the Antitumor Effect of Immune Checkpoint Blockade Investigators showed that cGMP-AMP synthase (cGAS) is indispensable for the antitumor effect of immune checkpoint blockade in mice. Wild-type, but not cGAS-deficient, mice exhibited slower growth of B16 melanomas in response to a PD-L1 antibody treatment. [Proc Natl Acad Sci USA] Abstract | Full Article During experimental autoimmune encephalomyelitis, researchers found increased expression of CH25H by microglia and CYP7B1 by CNS-infiltrating immune cells elevating the ligand concentration in the CNS. Two critical pro-inflammatory cytokines, interleukin-23 and interleukin-1 beta, maintained expression of EBI2 in differentiating Th17 cells. [Cell Rep] Full Article | Graphical Abstract The authors investigated the role of CXC chemokine receptor 3 (CXCR3) in the pathogenesis of autoimmune cholangitis. They took advantage of a unique CXCR3 knockout dnTGFβRII mouse to focus on the role of CXCR3, both by direct observation of its influence on the natural course of disease, as well as through adoptive transfer studies into Rag−/− mice. [J Autoimmun] Abstract Basophil-Derived IL-6 Regulates TH17 Cell Differentiation and CD4 T Cell Immunity Researchers showed a role for basophils in T helper (TH)17 cell development by using in vitro T cell differentiation and in vivo TH17-mediated inflammation models. Bone marrow derived-basophils and splenic basophils produced significant amounts of IL-6 as well as IL-4 following stimulation with IgE crosslink or cholera toxin. [Sci Rep] Full Article Bacterial Translocation Aggravates CCl4-Induced Liver Cirrhosis by Regulating CD4+ T Cells in Rats Scientists investigated the distribution of Treg, Th17, and Th1 cells in the intestinal lamina propria, liver and blood and explored their relationships with bacterial translocation. [Sci Rep] Full Article To evaluate the secretome of adipose tissue stem cells (ASCs), investigators administrated culture supernatant of ASCs and uncultured fresh medium into a mouse model of allergic airway inflammation. Subsequently they observed the mice for signs of inflammation and investigated Th1–, Th2–, and Treg-related cytokine levels as well as recruitment of Treg cells into the airway. [Stem Cell Res Ther] Full Article Researchers examined the role of donor bone marrow cells (BMCs) in the expansion of bioactive regulatory T (Treg) cells. The mouse model was transplanted with a heart allograft the day after treatment. They showed that transfer of spleen cells in place of BMCs failed to deplete host interferon-γ-producing CD8+T cells, expand host Ki67+CD4+CD25+Foxp3+ Treg cells, and prolong graft survival. [Eur J Immunol] Abstract In Situ Activation of Platelets with Checkpoint Inhibitors for Post-Surgical Cancer Immunotherapy Scientists showed that conjugating engineered monoclonal antibodies against programmed-death ligand 1 to the surface of platelets can reduce post-surgical tumor recurrence and metastasis. [Nat Biomed Eng] Full Article | Press Release Subscribe to our sister publications: Human Immunology News & Immunology of Infectious Disease News. | |
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REVIEWSMaking Mouse Models that Reflect Human Immune Responses The authors review recent studies that indicate that pathogen infections are important for the basal level of activation and the function of the immune system. Consideration of these environmental exposures of both humans and mice can potentially improve mouse models of human disease. [Trends Immunol] Abstract Visit our reviews page to see a complete list of reviews in the immune regulation research field. | |
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INDUSTRY NEWSX4 Pharmaceuticals announced the initiation of a Phase II/III study with the first patient dosed with X4P-001-LD for the treatment of WHIM syndrome, a sub-type of a primary immunodeficiency disease characterized by warts, hypogammaglobulinemia, infections, and myelokathexis or “WHIM.” [X4 Pharmaceuticals] Press Release Personal Genome Diagnostics Inc. announced that it has been awarded an SBIR contract from the National Cancer Institute for the development of a novel diagnostic to help identify patients who are most likely to benefit from treatment with immuno-oncology cancer drugs known as checkpoint inhibitors. [Personal Genome Diagnostics Inc.] Press Release | |
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POLICY NEWSThe £6 Billion Man: New Top Job in U.K. Science Goes to Mark Walport The government announced the selection of Mark Walport, currently the chief science adviser to the U.K. government, as head of UK Research and Innovation. The umbrella organization for the existing research councils will serve as the strategic command center of government research funding. [ScienceInsider] Editorial Trump Immigration Ban Upends International Work on Disease Efforts to combat diseases rely on networks of scientists to detect outbreaks early, understand how the diseases operate and then intervene. Researchers say that President Donald Trump’s travel ban challenges that process, putting the United States at risk. [Nature News] Editorial On 22 April, Empiricists around the Country Will March for Science The grassroots team coordinating the March for Science on Washington, D.C., have now set a date: 22 April. And they are inviting organizers in cities around the world to lead parallel demonstrations. [ScienceInsider] Editorial
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EVENTSNEW 30th Annual Canadian Society for Immunology (CSI) Conference Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESResearch Technologist – Cell Separation (STEMCELL Technologies Inc.) Scientist – Immunology (Moderna Therapeutics) Postdoctoral Fellow – Immunology (Institute of Molecular and Cell Biology) Scientist Positions – Immunology (New York Blood Center) Senior Scientist – (Immatics Biotechnologies GmbH) Senior Scientist – Immunology (Immusoft Corporation) Assistant Associate or Full Member – Cancer Immunology (Fred Hutchinson Cancer Research Center) Postdoctoral Fellow – Molecular Immunology (University of California, San Diego) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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