Immune Regulation News Volume 9.39 | Oct 13 2017

TOP STORY

Calcium Lets T Cells Use Sugar to Multiply & Fight Infection

A calcium signal controls whether immune cells can use the nutrients needed to fuel their multiplication into a cellular army designed to fight invading viruses. This is the finding of a study in human cells and mice. The study results concern the precise and massive immune counterattack by T cells in response to viral infection. [Press release from NYU School of Medicine discussing online prepublication in Immunity] Press Release | Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

Interconnected Subsets of Memory Follicular Helper T Cells Have Different Effector Functions

Researchers showed that both memory follicular helper T subsets sustain B-cell responses after reactivation. Local cells promote more plasma cell differentiation, whereas circulating cells promote more secondary germinal centers. [Nat Commun] Full Article

An NF-κB-MicroRNA Regulatory Network Tunes Macrophage Inflammatory Responses

Investigators describe a miRNA-based regulatory network that enables precise NF-κB activity in mouse macrophages. Elevated miR-155 expression potentiates NF-κB activity in miR-146a-deficient mice, leading to both an overactive acute inflammatory response and chronic inflammation. [Nat Commun] Full Article

Human Papillomavirus Oncoproteins Induce a Reorganization of Epithelial-Associated γδ T Cells Promoting Tumor Formation

The authors investigated the impact of γδ T cells in a transgenic mouse model of carcinogenesis induced by HPV16 oncoproteins. γδ T cells promoted the development of HPV16 oncoprotein-induced lesions. [Proc Natl Acad Sci USA] Abstract | Press Release

Foxo1 and Foxp1 Play Opposing Roles in Regulating the Differentiation and Antitumor Activity of T_H9 Cells Programmed by IL-7

Scientists found that pretreatment of naïve CD4⁺ T cells with IL-7 further enhanced their differentiation into T_H9 cells and augmented their antitumor activity. [Sci Signal] Abstract

IL-17–Secreting γδ T Cells Are Completely Dependent upon CCR6 for Homing to Inflamed Skin

Researchers report that a potent and specific small molecule antagonist of the CCR6 chemokine receptor, CCX2553, was efficacious in reducing multiple aspects of psoriasis in two different murine models of the disease. [J Immunol] Abstract

The ERM Protein Moesin Regulates CD8⁺ Regulatory T Cell Homeostasis and Self-Tolerance

Investigators showed that aging moesin-deficient mice develop a systemic lupus erythematosus-like autoimmune phenotype, which is characterized by elevated serum autoantibody levels and glomerulonephritis. [J Immunol] Abstract

S1P₁ Deletion Differentially Affects TH17 and Regulatory T Cells

To study the impact of sphingosine-1 phosphate receptor 1 (S1P₁) signaling on Th17 and T_reg cell biology, scientists specifically deleted S1P₁ in Th17 and T_reg cells using IL-17A^Cre and Foxp3^Cre mice, respectively. [Sci Rep] Full Article

Enzymatic Synthesis of Core 2 O-Glycans Governs the Tissue-Trafficking Potential of Memory CD8⁺ T Cells

Scientists demonstrated that cellular migration of memory CD8⁺ T cells into nonlymphoid tissues is driven by interleukin-15–stimulated enzymatic synthesis of core 2 O-glycans, which generates functional ligands for E- and P-selectins. [Sci Immunol] Abstract

Subscribe to our sister publications: Human Immunology News & Immunology of Infectious Disease News.

Emerging Targets in Cancer Immunotherapy

The authors present a summary of emerging immune targets with reported pre-clinical efficacy that have progressed to active investigation in clinical trials. These emerging targets include co-inhibitory and co-stimulatory markers of the innate and adaptive immune system. [Semin Cancer Biol] Abstract

Visit our reviews page to see a complete list of reviews in the immune regulation research field.

AbbVie and Turnstone Biologics Announce Global Collaboration on Viral Immunotherapies in Oncology

AbbVie and Turnstone Biologics announced a research, option and license agreement whereby AbbVie obtained an exclusive option to license up to three of Turnstone’s next-generation oncolytic viral immunotherapies. [AbbVie Inc.] Press Release

Stand Up To Cancer Awards Moffitt $2.67 Million to Study New Lung Cancer Immunotherapy

Moffitt Cancer Center announced it was awarded a $2.67 million dollar grant from Stand Up To Cancer to study a possible new immunotherapy for non-small cell lung cancer. [Moffitt Cancer Center] Press Release

VLP Therapeutics Announces Phase I SBIR Grant Award from National Cancer Institute

VLP Therapeutics, LLC announced the receipt of a Phase I grant from the National Cancer Institute under auspices of the Small Business Innovation Research (SBIR) program of the National Institutes of Health. [VLP Therapeutics, LLC] Press Release

European Drug Regulation at Risk of Stalling as Agency Prepares to Leave London

Drug regulation in Europe could temporarily freeze if the European Medicines Agency loses staff during its post-Brexit move from London. Up to 70 per cent of its 900 staff have said they would quit if the agency relocated to some of the cities bidding to host the organization. [Nature News] Editorial

NSF Drops Preproposals, Deadlines for Biologists Seeking Funding

The National Science Foundation (NSF) will no longer require biologists applying for grants to submit preproposals and to adhere to an annual deadline for submissions. The changes pull the plug on a five-year pilot project in two NSF divisions—and mark the agency’s latest attempt to reduce the burden of the grant review system on its staff and outside researchers without lowering its standards. [ScienceInsider] Editorial

South African Researchers Bemoan Slashed Funds

Academics in South Africa are in uproar after a government research agency announced plans to cut the budget of a prestigious grant program that rewards the country’s best researchers. [Nature News] Editorial

NEW World Vaccine Congress Washington 2018
April 3-5, 2018
Washington, D.C., United States

Visit our events page to see a complete list of events in the community.

NEW Tenured Track Faculty – Regenerative and Immune Engineering (Johns Hopkins University Biomedical Engineering)

NEW Postdoctoral Fellow – Immune Signaling Pathways (Universite de Liege)

Research Technologist – Immunotherapy (STEMCELL Technologies Inc.)

Scientist – Immunology (STEMCELL Technologies Inc.)

Postdoctoral Researcher – Tumor Immune Microenvironment (Columbia University)

Postdoctoral Fellow – Immunology (University of Rochester Medical Center)

Postdoctoral Fellow – Immunology (University of California, Los Angeles)

Postdoctoral Researcher – Development of Immune System (Lund University)

Postdoctoral Fellowship – Immunology (University of Georgia)

Postdoctoral Research Fellows – Systems Immunology (University of Oslo)

Research Fellow Position – Immunology Research (ShanghaiTech University)

Mouse Scientist – T Cell-Based Therapy (Tessa Therapeutics Pte Ltd.)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Immune Regulation News? Click here to submit!

Comments or suggestions? Submit your feedback here.