Immune Regulation News 9.40 October 20, 2017 | |
| |
TOP STORYiNKT Cells Orchestrate a Switch from Inflammation to Resolution of Sterile Liver Injury Using intravital microscopy, scientists observed that patrolling invariant natural killer T (iNKT) cells were initially excluded from a site of hepatic injury but subsequently were strategically arrested first via self-antigens and then by cytokines, circumscribing the injured site at exactly the location where monocytes co-localized and hepatocytes proliferated. [Immunity] Abstract | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)Researchers investigated the effect of bone marrow-derived and systemic CD27 deficiency in apolipoprotein E-deficient mice in early and advanced stages of atherosclerosis. In vitro, Tregs of CD27-deficient mice showed similar suppressive capacity compared with their wild-type controls and migrated equally towards CCL19 and CCL21. [Eur Heart J] Abstract Scientists found that murid herpesvirus 4 (MuHV-4) inhibited the development of house dust mite-induced experimental asthma by modulating lung innate immune cells. Infection with MuHV-4 caused the replacement of resident alveolar macrophages by monocytes with regulatory functions. [Nat Immunol] Abstract | Press Release Macrophage VLDLR Mediates Obesity-Induced Insulin Resistance with Adipose Tissue Inflammation Investigators showed that elevated very low-density lipoprotein receptor (VLDLR) expression in adipose tissue macrophages promotes adipose tissue inflammation and glucose intolerance in obese mice. In macrophages, VLDL treatment upregulated intracellular levels of C16:0 ceramides in a VLDLR-dependent manner, which potentiated pro-inflammatory responses and promoted M1-like macrophage polarization. [Nat Commun] Full Article Ets Transcription Factor GABP Controls T Cell Homeostasis and Immunity The authors showed that depletion of the E twenty-six (Ets) family transcription factor GA-binding protein (GABP) in T cells impairs T-cell homeostasis. In addition, GABP was critically required for antigen-stimulated T-cell responses in vitro and in vivo. [Nat Commun] Full Article A Nonimmune Function of T Cells in Promoting Lung Tumor Progression Using transplantable models of lung tumors in mice, investigators found that amphiregulin, a member of the epidermal growth factor family, was prominently up-regulated in intratumoral T reg cells. Furthermore, T cell–restricted amphiregulin deficiency resulted in markedly delayed lung tumor progression. [J Exp Med] Abstract The authors report that mature Tregs continue to require NF-κB signaling through IκB-kinase β (IKKβ) after thymic egress. Mice lacking IKKβ in mature Tregs developed scurfy-like immunopathology due to death of peripheral FoxP3+ Tregs. [Cell Rep] Full Article | Press Release | Graphical Abstract A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas Researchers performed integrative analysis of Notch-regulated transcripts, genomic binding of Notch transcription complexes, and genome conformation data to identify direct Notch target genes in mantle cell lymphoma (MCL) cell lines. [Cell Rep] Full Article | Graphical Abstract Investigators found that at high concentrations of resveratrol, human CD4+ T cells showed defective antigen receptor signaling and arrest at the G1 stage of the cell cycle, whereas at low concentrations, cells were readily activated and exhibited enhanced Sirt1 deacetylase activity. [Sci Signal] Abstract NK Cells Are Negatively Regulated by sCD83 in Experimental Autoimmune Uveitis The authors investigated the status of natural killer (NK) cells in experimental autoimmune uveitis (EAU). They found that the number of CD83+CD3−NK1.1+ cells was increased in the inflamed eyes and spleens of the EAU mouse model. [Sci Rep] Full Article Interleukin-10 from CD4+ Follicular Regulatory T Cells Promotes the Germinal Center Response CD4+ follicular regulatory T (Tfr) cells suppress B cell responses through modulation of follicular helper T cells and germinal center (GC) development. Scientists found that Tfr cells can also promote the GC response through provision of IL-10 after acute infection with lymphocytic choriomeningitis virus. [Sci Immunol] Abstract Subscribe to our sister publications: Human Immunology News & Immunology of Infectious Disease News. | |
| |
REVIEWSB Cells in Type 1 Diabetes Mellitus and Diabetic Kidney Disease The authors discuss the role of B cells in the pathogenesis of type 1 diabetes mellitus and how these cells are activated during disease development. They speculate on how B cells might contribute to the development of diabetic kidney disease. [Nat Rev Nephrol] Abstract Visit our reviews page to see a complete list of reviews in the immune regulation research field. | |
| |
INDUSTRY NEWSKite announced that the FDA has granted regular approval to Yescarta™, the first chimeric antigen receptor T cell (CAR T) therapy for the treatment of adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy, including diffuse large B-cell lymphoma (DLBCL) not otherwise specified, primary mediastinal large B-cell lymphoma, high-grade B-cell lymphoma, and DLBCL arising from follicular lymphoma. [Gilead Sciences] Press Release | Editorial AbbVie and Harpoon Therapeutics Announce Immuno-Oncology Research Collaboration AbbVie and Harpoon Therapeutics announced that they have entered an immuno-oncology research collaboration. The goal of the collaboration is to incorporate Harpoon’s tri-specific T-cell activating construct platform with AbbVie’s research-stage immuno-oncology targets to develop novel cancer therapeutics. [AbbVie Inc.] Press Release Biotech Holdings announced filing of a patent application entitled “Reverse Abscopal Effect for Treatment of Autoimmunity.” The patent covers recent data showing that injection of ProCell stem cells in one joint of animals suffering from rheumatoid arthritis leads to remission of the disease in all the joints. [BioTech Holdings (PR Newswire Association LLC.)] Press Release | |
| |
POLICY NEWSRand Paul Takes a Poke at U.S. Peer Review Panels Senate Republicans have launched a new attack on peer review by proposing changes to how the U.S. government funds basic research. [ScienceInsider] Editorial Top Chinese University to Consider Social-Media Posts in Researcher Evaluations One of China’s most prestigious universities plans to give some articles in newspapers and posts on major social-media outlets the same weight as peer-reviewed publications when it evaluates researchers. [Nature News] Editorial Japanese Research Leaders Warn about National Science Decline As Japan heads towards a national election, scientific leaders worry that the outcome will do little to address long-standing concerns about the country’s deteriorating research landscape. They say that a decline in funding and a shift away from basic research has undermined Japan’s capacity to compete against both established scientific powerhouses and emerging ones such as China. [Nature News] Editorial
| |
EVENTSNEW Keystone Symposia: Myeloid Cells Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESResearch Technologist – Immunotherapy (STEMCELL Technologies Inc.) Scientist – Immunology (STEMCELL Technologies Inc.) Postdoctoral Fellow – Immune Signaling Pathways (Universite de Liege) Postdoctoral Researcher – Tumor Immune Microenvironment (Columbia University) Postdoctoral Fellow – Immunology (University of Rochester Medical Center) Postdoctoral Fellow – Immunology (University of California, Los Angeles) Postdoctoral Researcher – Development of Immune System (Lund University) Research Fellow Position – Immunology Research (ShanghaiTech University) Mouse Scientist – T Cell-Based Therapy (Tessa Therapeutics Pte Ltd.) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Immune Regulation News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|