| PUBLICATIONS (Ranked by impact factor of the journal) | Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection Type I interferons (IFN-I) are critical for antiviral immunity; however, chronic IFN-I signaling is associated with hyperimmune activation and disease progression in persistent infections. The authors demonstrated in mice that blockade of IFN-I signaling diminished chronic immune activation and immune suppression, restored lymphoid tissue architecture, and increased immune parameters associated with control of virus replication, ultimately facilitating clearance of the persistent infection. [Science] Abstract | Press Release Persistent LCMV Infection Is Controlled by Blockade of Type I Interferon Signaling Researchers demonstrated that blockade of type I interferon (IFN-I) signaling using an IFN-I receptor neutralizing antibody reduced immune system activation, decreased expression of negative immune regulatory molecules, and restored lymphoid architecture in mice persistently infected with lymphocytic choriomeningitis virus. [Science] Abstract | Press Release Comprehensive Analysis of Dengue Virus-Specific Responses Supports an HLA-Linked Protective Role for CD8+ T Cells The role of CD8+ T cells in dengue virus infection and subsequent disease manifestations is not fully understood. According to the original antigenic sin theory, skewing of T-cell responses induced by primary infection with one serotype causes less effective response upon secondary infection with a different serotype, predisposing individuals to severe disease. A comprehensive analysis of CD8+ responses in the general population from the Sri Lankan hyperendemic area, involving the measurement of ex vivo IFNγ responses associated with more than 400 epitopes, challenges the original antigenic sin theory. [Proc Natl Acad Sci USA] Abstract | Press Release The Immune Complex CTA1-DD/IgG Adjuvant Specifically Targets Connective Tissue Mast Cells through FcγRIIIA and Augments Anti-HPV Immunity after Nasal Immunization Researchers previously reported that CTA1-DD/IgG immune complexes augment antibody responses in a mast cell-dependent manner following intranasal (IN) immunizations. However, from a safety perspective, mast cell activation could preclude clinical use. Therefore, they extended these studies and demonstrated that CTA1-DD/IgG immune complexes administered IN did not trigger an anaphylactic reaction. [Mucosal Immunol] Abstract Potentiating Functional Antigen-Specific CD8+ T Cell Immunity by a Novel PD1 Isoform-Based Fusion DNA Vaccine Although upregulated programmed death-1 (PD1) in chronic infections (such as HIV-1 and tuberculosis) impedes T cell responses, blocking the PD1/PD-L pathway could functionally rescue the “exhausted” T cells. However, there exists a number of PD1 spliced variants with unknown biological function. Researchers identified a new isoform of human PD1 (Δ42PD1) that contains a 42-nucleotide in-frame deletion located at exon 2 domain found expressed in peripheral blood mononuclear cells. [Mol Ther] Abstract Inhibition of Ondoleamine 2, 3- Dioxygenase (IDO) Enhances the T Cell Response to Influenza Virus Infection The impact of IDO on the primary immune response to influenza virus infection was determined using the IDO inhibitor 1-methyl-D, L-tryptophan (1MT). C57BL/6 mice treated with 1MT and infected with A/HKx31 influenza virus had increased numbers of activated and functional CD4+, influenza-specific CD8+ T cells, and effector memory cells in the lung. Inhibition of IDO increased the Th1 response in CD4+ T cells as well as enhanced the Th17 response. [J Gen Virol] Abstract HIV Interleukin-7 Promotes HIV Persistence during Antiretroviral Therapy By isolating large numbers of CD4+ T cells from HIV-infected subjects, researchers demonstrated that IL-7 enhances viral production in productively infected cells but does not disrupt viral latency in latently infected cells isolated from subjects who received antiretroviral therapy for years. [Blood] Abstract The Immunologic Effects of Maraviroc Intensification in Treated HIV-Infected Individuals with Incomplete CD4+ T cell Recovery: A Randomized Trial Researchers randomized 45 HIV-infected subjects with CD4 counts less than 350 cells/mm3 and plasma HIV RNA levels less than 48 copies/ml on antiretroviral therapy (ART) to add maraviroc vs. placebo to their existing regimen for 24 weeks followed by 12 weeks on ART alone. Compared to placebo-treated subjects, maraviroc-treated subjects unexpectedly experienced a greater median increase in %CD38+HLA-DR+ peripheral blood CD8+ T cells at week 24, and less of a decline in activated CD4+T cells. [Blood] Abstract SHIV Antigen Immunization Alters Patterns of Immune Responses to SHIV/Malaria Co-Infection and Protects against Life-Threatening SHIV-Related Malaria Overlapping endemicity of HIV and malaria suggests that HIV/malaria co-infection frequently complicates acute and chronic HIV infection. Scientists showed that vaccination of macaques with recombinant(r) Listeria ΔactA prfA* expressing SHIV gag and env elicited Gag and Env-specific T-cell responses, and protected against life-threatening SHIV-related malaria after SHIV/P. fragile co-infection. [J Infect Dis] Abstract Low-Level Viremia Is Associated with Non-B Subtypes in Patients Infected with HIV with Virological Success following HAART Introduction This prospective study aimed to determine factors associated with detection of very low-level viremia in patients infected with HIV-1 with virological success following HAART introduction. Fifty-seven patients, mostly treated with a protease inhibitor-based regimen, were included and followed for 2 years. [J Med Virol] Abstract A Truncated Plasmid-Encoded HIV-1 Reverse Transcriptase Displays Strong Immunogenicity Besides being an important target in the antiretroviral therapy against the human immunodeficiency virus type 1 (HIV-1), the HIV-1 reverse transcriptase (RT) enzyme has potential as a vaccine antigen. Researchers explored the ability of plasmid-encoded RT to induce cell-mediated immune responses. The strategy for increasing the immunogenicity of the protein was to delete non- or low-immunogenic parts in order to focus the immune responses to known immunogenic regions. [Viral Immunol] Abstract Don’t forget to subscribe to our sister publications: Human Immunology News and Immune Regulation News! |
| INDUSTRY NEWS | An Update on EpiVax’ H7N9 “FastVax” Progress EpiVax scientists are currently in discussions with groups in China, Canada and the US about producing an H7N9 vaccine. They highlight a few key points about the current progress of EpiVax’ FastVax vaccine design. [EpiVax, Inc.] Press Release World Demand for Infection Prevention Products to Reach $130 Billion in 2017 The upgrading and enforcement of patient and staff safety standards in health care facilities, coupled with an expanding volume of hospital, surgical, and outpatient procedures, will promote overall gains. China, the United States, India, Russia, Japan, Germany, France, Italy, Brazil, and the United Kingdom will comprise the 10 largest national markets, combining to account for nearly two-thirds of global demand in 2017. [PR Newswire Association LLC] Press Release Benitec Selects University of California, San Diego as a Site for Phase I/II Clinical Trial of TT-034 in Patients with Hepatitis C Infections RNAi-based therapeutics company Benitec Biopharma Limited announced the selection of the University of California, San Diego, Health Sciences as the second site for its upcoming phase I/II first-in-man trial for TT-034 in Hepatitis C infections. Benitec previously announced the selection of Duke Clinical Research Unit as the other site. [Benitec Biopharma, Ltd.] Press Release Benitec’s Hep C Program Moves Closer to Clinic with RAC Application Benitec Biopharma, which is developing innovative therapeutics based on its gene-silencing technology, DNA-directed RNA interference, announced that it has moved closer to clinical trials for TT-034, a first-in-class treatment of chronic hepatitis C virus. [Benitec Biopharma, Ltd.] Press Release |
| EVENTS | NEW IDWeek 2013 October 2-6, 2013 San Francisco, United States Visit our events page to see a complete list of events in the infectious disease community. |
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