Notch2-Dependent Classical Dendritic Cells Orchestrate Intestinal Immunity to Attaching-and-Effacing Bacterial Pathogens Scientists used genetic techniques to deplete mice of specific subsets of classical dendritic cells and analyzed immunity to the attaching-and-effacing pathogen Citrobacter rodentium. [Nat Immunol] Abstract CD8 T Cell Exhaustion in Human Visceral Leishmaniasis To better understand the role of CD8 T cells in human visceral leishmaniasis, the authors examined molecules associated with anergy and cytotoxic T lymphocytes in peripheral blood mononuclear cells and splenic aspirates, and in CD8 cells derived from these tissues. [J Infect Dis] Abstract Cytokine and Chemokine Profiles in Lung Tissues from Fatal Cases of 2009 Pandemic Influenza A (H1N1) Researchers investigated viral load, the immune response, and apoptosis in lung tissues from 50 fatal cases with 2009 pH1N1 virus infection. The results suggested that 7 of the 27 cytokines/chemokines showed remarkably high expression, including IL-1 receptor antagonist protein, IL-6, tumor necrosis factor-α, IL-8, monocyte chemoattractant protein-1, macrophage inflammatory protein 1-β, and interferon-inducible protein-10 in lung tissues of 2009 pH1N1 fatal cases. [Am J Pathol] Abstract TNF-α Acts as an Immunoregulator in the Mouse Brain by Reducing the Incidence of Severe Disease Following Japanese Encephalitis Virus Infection The authors’ findings provide the first evidence that TNF-α has an immunoregulatory effect on pro-inflammatory cytokines in the central nervous system during Japanese encephalitis virus infection and consequently protects the animals from fatal disease. [PLoS One] Full Article CD8low T-Cell Subpopulation Is Increased in Patients with Chronic Hepatitis B Virus Infection Peripheral blood samples of 47 chronic hepatitis B patients and 19 healthy controls were collected and tested for the frequency and phenotype of CD8+ T cells with down-regulated CD8 expression (CD8low T cells). [Mol Immunol] Abstract HIV Clinical Impact of Altered T-Cell Homeostasis in Treated HIV Patients Enrolled in a Large Canadian Observational Cohort Scientists investigated the probability of transitioning in or out of the CD3+ T-cell homeostatic range during antiretroviral therapy, and they assessed the clinical impact of lost T-cell homeostasis on AIDS-defining illnesses or death. [AIDS] Abstract B Cells from Knock-In Mice Expressing Broadly Neutralizing HIV Antibody b12 Carry an Innocuous B Cell Receptor Responsive to HIV Vaccine Candidates To generate small animal models to test vaccine candidates, scientists generated targeted transgenic (knock-in) mice expressing, in the physiological Ig H and L chain loci, two well-studied broadly neutralizing antibodies: 4E10, which interacts with the membrane proximal external region of gp41, and b12, which binds to the CD4 binding site on gp120. [J Immunol] Abstract Discordance in CD4+T-Cell Levels and Viral Loads with Co-Occurrence of Elevated Peripheral TNF-α and IL-4 in Newly Diagnosed HIV-TB Co-Infected Cases Researchers aimed to collect the baseline information pertaining to the immune status of HIV-tuberculosis (TB) co-infected patients and correlate the same with CD4+T cell levels and viral loads at the time of diagnosis prior to any drug therapy. [PLoS One] Full Article IL-4 and IL-13 Mediated Down-Regulation of CD8 Expression Levels Can Dampen Anti-Viral CD8+ T Cell Avidity Following HIV-1 Recombinant Pox Viral Vaccination The authors have previously shown that mucosal HIV-1 recombinant pox viral vaccination can induce high, avidity HIV-specific CD8+ T cells with reduced interleukin (IL)-4 and IL-13 expression compared to, systemic vaccine delivery. In this study, they investigated how these cytokines act to regulate anti-viral CD8+ T cell avidity following HIV-1 recombinant pox viral prime-boost vaccination. [Vaccine] Abstract |