Human Herpesvirus 6A Infection and Immunopathogenesis in Humanized Rag2−/−γc−/− Mice Investigators showed that Rag2−/−γc−/− mice humanized with cord blood-derived human hematopoietic stem cells produce human T cells that express the major HHV-6A receptor, CD46. Both cell-associated and cell-free viral transmission of HHV-6A into the peritoneal cavity resulted in detectable viral DNA in at least one of the samples analyzed in nearly all engrafted mice. [J Virol] Abstract Hepatitis C Virus Induces IL-1β/IL-18 in Circulatory and Resident Liver Macrophages Scientists examined induction of interleukin (IL)-1β/IL-18 secretion following hepatitis C virus (HCV) infection. Their results demonstrated that monocyte derived human macrophages incubated with cell culture grown HCV enhance the secretion of IL-1β/IL-18 in culture supernatants. [J Virol] Abstract Optimal Conditions Required for Influenza A Infection-Enhanced Cross-Priming of CD8+ T Cells Specific to Cell-Associated Antigens Researchers have recently shown that influenza A virus (IAV) infection of allogeneic cells lead to enhanced cross-priming of TCD8+ specific to cellular antigens. To develop this into a potential vaccine strategy, here, they have systematically investigated the numbers of allogeneic cells infected by IAV, IAV doses and their infectious activity, the length of in vitro infection and other associated factors. [Immunol Cell Biol] Abstract Molecular Characterization of T Cell Receptor Beta Variable in the Peripheral Blood T Cell Repertoire in Subjects with Active Tuberculosis or Latent Tuberculosis Infection In 42 subjects with active tuberculosis or latent tuberculosis infection, peripheral blood mononuclear cells and their subsets were separated and sorted. The molecular profiles of the T cell receptor beta variable complementarity determining region 3 in the three cell populations were investigated using their recently developed gene melting spectral pattern assay. [BMC Infect Dis] Full Article HIV Immune Clearance of Highly Pathogenic SIV Infection The authors recently reported that approximately 50% of rhesus macaques vaccinated with simian immunodeficiency viruses (SIV) protein-expressing rhesus cytomegalovirus (RhCMV/SIV) vectors manifest durable, aviremic control of infection with the highly pathogenic strain SIVmac239. Here they showed that regardless of the route of challenge, RhCMV/SIV vector-elicited immune responses control SIVmac239 after demonstrable lymphatic and hematogenous viral dissemination, and that replication-competent SIV persists in several sites for weeks to months. [Nature] Abstract HIV-1 gp120 Induced Expansion of Myeloid Derived Suppressor Cells Is Dependent on Interleukin-6 and Suppresses Immunity The authors investigated the role of myeloid derived suppressor cells during HIV-1 infection. PBMCs were cultured with gp120, infectious or inactivated HIV-1 with or without anti-IL-6 antibody. [J Infect Dis] Abstract Higher NK Cell Interferon Gamma Production Is Associated with Delayed HIV Disease Progression in LTNPs Scientists examined the function of natural killer (NK) cells in Chinese patients who were HIV-infected but treatment-naïve. These individuals include primary HIV-infected patients, typical progressors, and long-term nonprogressors (LTNPs). [J Clin Immunol] Abstract HIV-1 Induces the First Signal to Activate the NLRP3 Inflammasome in Monocyte-Derived Macrophages Investigators evaluated whether HIV-1 can induce activation of the NLRP3 inflammasome. Human primary monocyte-derived macrophages were infected with HIV-1 in the absence or presence of classical NLRP3 inflammasome activators, and IL-1β release was assessed by ELISA. [Intervirology] Abstract |