Immunology of Infectious Disease News Volume 13.00 | Jan 08 2025

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    Jamie Kang
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    2025-01-07 | IIDN 13.00


    Immunology of Infectious Disease News by STEMCELL Technologies
    Vol. 13.00 – 8 January, 2025
    TOP STORY

    Phenotypic Evolution of SARS-CoV-2 Spike during the COVID-19 Pandemic

    Scientists generated a panel of recombinant viruses carrying different spike proteins from 27 variants circulating between 2020 and 2024 in the same genomic background.
    [Nature Microbiology]

    Full Article
    PUBLICATIONSListed by the impact factor of the journal

    SARS-CoV-2 Infection of Human Pluripotent Stem Cell-Derived Vascular Cells Reveals Smooth Muscle Cells as Key Mediators of Vascular Pathology during Infection

    Researchers developed a model of SARS-CoV-2 infection using human-induced pluripotent stem cell-derived endothelial cells, pericytes), and smooth muscle cells to recapitulate the vascular pathology associated with SARS-CoV-2 exposure.
    [Nature Communications]

    Full Article

    Dual Inhibitors of SARS-CoV-2 3CL Protease and Human Cathepsin L Containing Glutamine Isosteres Are Anti-CoV-2 Agents

    Investigators demonstrated the value of a second generation of cysteine protease inhibitors that comprised a single agent that acted on both human cathepsin L and SARS-CoV-2 3-chymotrypsin-like (3CL) protease.

    [Journal of The American Chemical Society]

    Full ArticleGraphical Abstract

    The Identification of a SARS-CoV2 S2 Protein Derived Peptide with Super-Antigen-Like Stimulatory Properties on T Cells

    The authors identified a region in the SARS-CoV-2 S2 spike protein with sequence homology to bacterial super-antigens.
    [Communications Biology]

    Full Article

    Vaccination prior to SARS-CoV-2 Infection Does Not Affect the Neurologic Manifestations of Long COVID

    Scientists investigated whether vaccination prior to infection altered the subsequent neurologic post-acute sequelae of SARS-CoV-2 infection.
    [Brain Communications]

    Full ArticlePress Release

    Incidence and Outcome of Hepatitis D Virus Infection in People with HIV in the Era of Tenofovir-Containing Antiretroviral Therapy

    Researchers investigated the incidence of hepatitis D virus infection and its clinical impact in hepatitis B virus-coinfected people with HIV in the era of tenofovir-containing antiretroviral therapy.
    [Clinical Infectious Diseases]

    Abstract

    Vaccination with Different Group 2 Influenza Subtypes Alters Epitope Targeting and Breadth of Hemagglutinin Stem-Specific Human B Cells

    Scientists characterized the stem-specific repertoire of individuals vaccinated with one of three group two influenza subtypes.
    [Science Translational Medicine]

    Abstract

    Nanoparticle Vaccine Triggers Interferon-Gamma Production and Confers Protective Immunity against Porcine Reproductive and Respiratory Syndrome Virus

    Researchers designed and produced a self-assembling nanoparticle vaccine derived from thermophilic archaeal ferritin to combat epidemic porcine reproductive and respiratory syndrome virus.
    [ACS Nano]

    AbstractGraphical Abstract

    A Modular Self-Assembling and Self-Adjuvanting Multiepitope Peptide Nanoparticle Vaccine Platform to Improve the Efficacy and Immunogenicity of BCG

    While many studies on booster subunit vaccines have concentrated on recombinant proteins, here scientists developed a novel modular peptide-based subunit vaccine platform that was flexible, cold-chain independent and customizable to diverse circumstances and populations.
    [Small]

    Abstract

    Pre-HIV α4β7hi CD4+ T Cells and HIV Risk among Heterosexual Individuals in Africa

    Investigators suggested that α4β7hi expression on CD4+ T cells may not predict HIV acquisition and progression in all contexts, which may be due to cohort effects, modes of transmission, viral clade, or other factors.
    [Journal of Infectious Diseases]

    Abstract

    Follicular Cytotoxic T Cells Is Dysfunctional in Chronic Hepatitis B Patients with Non-Alcoholic Fatty Liver Disease

    Given the impact of nonalcoholic fatty liver disease (NAFLD) on T cell activation and proliferation functions, scientists aimed to explore the heterogeneity of follicular cytotoxic T cells in chronic hepatitis B patients with NAFLD.
    [Biochimica et Biophysica Acta-Molecular Basis of Disease]

    AbstractGraphical Abstract
    With ImmunoCultâ„¢ Dendritic Cell Culture Kit, you can generate immature, as well as mature, dendritic cells from human monocytes.
    REVIEWS

    Infectious Agents in the Pathogenesis of Autoimmune Rheumatic Diseases

    The authors provide a brief review of the role of viruses in the outset and development of autoimmune rheumatic diseases.
    [Translational Research]

    Full Article
    INDUSTRY AND POLICY NEWS

    OPKO Health’s ModeX Therapeutics Announces Epstein-Barr Virus Vaccine Candidate Enters Phase I Clinical Study in Collaboration with Merck

    ModeX Therapeutics Inc. announces dosing of the first participant in the Phase I study of an Epstein-Barr Virus vaccine candidate being developed in collaboration with Merck, known as MSD outside the United States and Canada.
    [ModeX Therapeutics, Inc. (Globe Newswire)]

    Press Release
    FEATURED EVENT

    DNA Methylation, Clonal Hematopoiesis, and Cancer

    February 1-4, 2025
    San Diego, California, United States

    > See All Events

    JOB OPPORTUNITIES

    Group Leader – Molecular Infection Medicine

    Ume̴ University РUme̴, Sweden

    PhD Studentship – Chronic Skin Infections

    Ulster University – Belfast, Northern Ireland, United Kingdom

    Assistant/Associate Professor – Transplant Infectious Disease

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    Group Leader – Infection Biology

    Institute of Research for Infectious Diseases of Montpellier – Montpellier, France

    Clinical Research Associate – Pulmonary Research Program

    Cedars Sinai – Los Angeles, California, United States

    > See All Jobs

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