 | | Vol. 13.01 – 22 January, 2025 |
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| Investigators conducted a double-blind, randomized controlled trial involving vaccination and challenge in 33 adult human volunteers, using the live–attenuated yellow fever and chimeric Japanese encephalitis–YF17D vaccines.
[Nature microbiology] |
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 | | PUBLICATIONSListed by the impact factor of the journal |
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| A sequential intramuscular+intranasal vaccination strategy significantly enhanced both upper respiratory and systemic antiviral immunity in a mouse model, characterized by the rapid increase in systemic and mucosal T and B cell responses, particularly the mucosal IgA antibody response.
[Journal of Clinical Investigation] |
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| Scientists investigated whether vaccination prior to infection altered the subsequent neurologic post-acute sequelae of SARS-CoV-2 infection.
[Brain Communications] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Investigators introduced a promising strategy for developing cell-based and personalized tumor vaccines by fully taking advantage of the immune stimulation mechanisms of immunogenic cell death occurrence in tumor cells, influenza virus modification, and nanoscale delivery.
[ACS Nano] |
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| Researchers found that the omentum, a reservoir for B. abortus, promoted bacterial persistence, and caused CD4+ and CD8+ T cell immunosuppression by IL-1RA secreted by PD-L1+Sca-1+ neutrophils.
[Nature Communications] |
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| Investigators revealed that CD8+ T cells in HIV-infected subjects were inclined towards senescence, and they identified that serine hydroxymethyltransferase 2 (SHMT2), a key enzyme in serine metabolism, played a role in CD8+ T cell senescence.
[eBioMedicine] |
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| Scientists defined the impact of influenza virus infection on a subsequent virus encephalitis. They used a model system in which mice were given influenza A virus infection 8 days prior to Semliki Forest virus infection.
[Journal of Virology] |
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| Researchers evaluated the immunogenicity and efficacy of the promising mycobacterial antigen PPE15, formulated with five adjuvants developed by the Vaccine Formulation Institute.
[Scientific Reports] |
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| Using a mouse model of infection, scientists found that C. trachomatis uptake reduced the viability of Classical dendritic cells 1s (cDC1s) and cDC2s both in vitro and in vivo, with cDC1s experiencing more death.
[Infection and Immunity] |
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| Baseline CD4+ T cell count at the onset of treatment served as a reliable predictor of immunological reconstitution in HIV-infected children with or without tuberculosis co-infection.
[BMC Research Notes] |
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| The authors explore the hepatitis C virus targets and the different vaccination approaches, encompassing different expression systems, antigen selection strategies, and delivery methods, focusing on those aimed at eliciting a broad and effective humoral response.
[Expert Review of Vaccines] |
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| InflaRx N.V. announced that the European Commission has granted marketing authorization under exceptional circumstances for GOHIBIC® for the treatment of adult patients with SARS-CoV-2-induced ARDS who are receiving systemic corticosteroids as part of standard of care.
[InflaRx N.V.] |
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| | Punta Cana, Dominican Republic |
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| | Washington University in St. Louis – St. Louis, Missouri, United States |
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| | Umeå University – Umeå, Sweden |
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| | Ulster University – Belfast, Northern Ireland, United Kingdom |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| | Institute of Research for Infectious Diseases of Montpellier – Montpellier, France |
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