 | | Vol. 13.02 – 5 February, 2025 |
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| Researchers measured plasma biomarkers linked to Alzheimer’s disease pathology in the UK Biobank before and after serology-confirmed SARS-CoV-2 infections.
[Nature Medicine] |
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 | | PUBLICATIONSListed by the impact factor of the journal |
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| Investigators showed that the SARS-CoV-2 accessory protein, ORF9b, but not other SARS-CoV-2 accessory proteins, strongly activated inflammasome-dependent caspase-1 in A549 lung carcinoma cells and THP-1 monocyte-macrophage cells.
[Journal of Medical Virology] |
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| The COVIVAX study assessed the association between COVID-19 vaccination and the risk of common neurological disorders in a multicenter case-control design.
[Scientific Reports] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| To devise a strategy to protect allogeneic CAR T cells from host immune cells, researchers turned to lymphotropic viruses that have evolved integrated mechanisms for the immune escape of virus-infected lymphocytes.
[Nature] |
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| Scientists showed that human enteric α-defensin 5 (HD5) induced abundant filopodial extensions in epithelial cells that captured Shigella, a major human enteroinvasive pathogen that was able to exploit these filopodia for invasion, revealing a mechanism for HD5-augmented bacterial invasion.
[Nature Microbiology] |
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| The authors presented MixInfect2, a new tool to accurately detect mixed samples from Mycobacterium tuberculosis short-read whole genome sequence data.
[Genome Medicine] |
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| Investigators showed that mRNAs highly induced in synMuv B mutants were congruent with those induced by Orsay RNA virus infection, suggesting that the enhanced RNAi of synMuv B mutants may also be triggered by down-regulation of synMuvB gene activity in an Orsay virus infection of wild type.
[PLOS Biology] |
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| The authors hypothesized that diversifying T-cell responses, particularly targeting conserved viral proteins such as the influenza A virus (IAV) nucleoprotein, could protect against both epidemic and pandemic IAV strains.
[Journal of Virology] |
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| Investigators highlighted the importance of considering fluctuations in vector immunity in relation to the length of a thermal challenge to understand natural variation in vector response to viruses and frame realistic transmission models.
[Communications Biology] |
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| Researchers investigated the modulation of different splenic subsets of B cells during Plasmodium yoelii infection. Balb/c mice infected with each Plasmodium yoelii XL and XNL parasite were used for phenotypic characterization of splenic B cell subsets through flow cytometry.
[Acta Tropica] |
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| The authors review the factors affecting the disease severity, the genetics of host–parasite interaction, immune evasion mechanisms, and approaches potentially to improve host immune response for vaccine development.
[PLOS Pathogens] |
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| Pfizer, Inc. announced positive topline results from the progression-free survival analysis of the Phase III BREAKWATER study of BRAFTOVI® in combination with cetuximab and mFOLFOX6 in patients with metastatic colorectal cancer harboring a BRAF V600E mutation.
[Pfizer, Inc.] |
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| | San Diego, California, United States |
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| | University of Bristol – Bristol, England, United Kingdom |
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| | Washington University in St. Louis – St. Louis, Missouri, United States |
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| | Umeå University – Umeå, Sweden |
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| | Ulster University – Belfast, Northern Ireland, United Kingdom |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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