Immunology of Infectious Disease News Volume 13.02 | Feb 05 2025

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    2025-02-05 | IIDN 13.02


    Immunology of Infectious Disease News by STEMCELL Technologies
    Vol. 13.02 – 5 February, 2025
    TOP STORY

    Plasma Proteomic Evidence for Increased β-Amyloid Pathology after SARS-CoV-2 Infection
    Researchers measured plasma biomarkers linked to Alzheimer’s disease pathology in the UK Biobank before and after serology-confirmed SARS-CoV-2 infections.
    [Nature Medicine]
    Full Article
    PUBLICATIONSListed by the impact factor of the journal

    Induction of the Inflammasome by the SARS-CoV-2 Accessory Protein ORF9b, Abrogated by Small-Molecule ORF9b Homodimerization Inhibitors
    Investigators showed that the SARS-CoV-2 accessory protein, ORF9b, but not other SARS-CoV-2 accessory proteins, strongly activated inflammasome-dependent caspase-1 in A549 lung carcinoma cells and THP-1 monocyte-macrophage cells.
    [Journal of Medical Virology]
    Abstract

    Multicentre Case-Control Study on the Association between COVID-19 Vaccines and Neurological Disorders (COVIVAX)
    The COVIVAX study assessed the association between COVID-19 vaccination and the risk of common neurological disorders in a multicenter case-control design.
    [Scientific Reports]
    Full Article

    HIV Immune Evasin Nef Enhances Allogeneic CAR T Cell Potency
    To devise a strategy to protect allogeneic CAR T cells from host immune cells, researchers turned to lymphotropic viruses that have evolved integrated mechanisms for the immune escape of virus-infected lymphocytes.
    [Nature]
    Abstract

    Shigella Infection Is Facilitated by Interaction of Human Enteric α-Defensin 5 with Colonic Epithelial Receptor P2Y11
    Scientists showed that human enteric α-defensin 5 (HD5) induced abundant filopodial extensions in epithelial cells that captured Shigella, a major human enteroinvasive pathogen that was able to exploit these filopodia for invasion, revealing a mechanism for HD5-augmented bacterial invasion.
    [Nature Microbiology]
    Abstract

    A New Method for Detecting Mixed Mycobacterium tuberculosis Infection and Reconstructing Constituent Strains Provides Insights into Transmission
    The authors presented MixInfect2, a new tool to accurately detect mixed samples from Mycobacterium tuberculosis short-read whole genome sequence data.
    [Genome Medicine]
    Full Article

    Decreased SynMuv B Gene Activity in Response to Viral Infection Leads to Activation of the Antiviral RNAi Pathway in C. elegans
    Investigators showed that mRNAs highly induced in synMuv B mutants were congruent with those induced by Orsay RNA virus infection, suggesting that the enhanced RNAi of synMuv B mutants may also be triggered by down-regulation of synMuvB gene activity in an Orsay virus infection of wild type.
    [PLOS Biology]
    Full Article

    Diversifying T Cell Responses: Safeguarding against Pandemic Influenza with Mosaic Nucleoprotein
    The authors hypothesized that diversifying T-cell responses, particularly targeting conserved viral proteins such as the influenza A virus (IAV) nucleoprotein, could protect against both epidemic and pandemic IAV strains.
    [Journal of Virology]
    Full Article

    Prolonged Exposure to Heat Enhances Mosquito Tolerance to Viral Infection
    Investigators highlighted the importance of considering fluctuations in vector immunity in relation to the length of a thermal challenge to understand natural variation in vector response to viruses and frame realistic transmission models.
    [Communications Biology]
    Full Article

    Differential B Cell-Mediated Immune Response during Plasmodium yoelii Infection in Mice
    Researchers investigated the modulation of different splenic subsets of B cells during Plasmodium yoelii infection. Balb/c mice infected with each Plasmodium yoelii XL and XNL parasite were used for phenotypic characterization of splenic B cell subsets through flow cytometry.
    [Acta Tropica]
    AbstractGraphical Abstract
    Learn how the SARS-CoV-2 genotype impacts viral load, transmission, and spread with Dr. Judd F. Hultquist.
    REVIEWS

    Malaria: Factors Affecting Disease Severity, Immune Evasion Mechanisms, and Reversal of Immune Inhibition to Enhance Vaccine Efficacy
    The authors review the factors affecting the disease severity, the genetics of host–parasite interaction, immune evasion mechanisms, and approaches potentially to improve host immune response for vaccine development.
    [PLOS Pathogens]
    Full Article
    INDUSTRY AND POLICY NEWS

    Pfizer’s BRAFTOVI® Combination Regimen Significantly Improved Progression-Free Survival and Overall Survival in Phase III BREAKWATER Trial
    Pfizer, Inc. announced positive topline results from the progression-free survival analysis of the Phase III BREAKWATER study of BRAFTOVI® in combination with cetuximab and mFOLFOX6 in patients with metastatic colorectal cancer harboring a BRAF V600E mutation.
    [Pfizer, Inc.]
    Press Release
    FEATURED EVENT

    10th Annual Innate Killer Summit
    May 3-5, 2025
    San Diego, California, United States

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    JOB OPPORTUNITIES

    Clinical Lecturer – Renal Infection
    University of Bristol – Bristol, England, United Kingdom

    Postdoctoral Research Associate – Infectious Diseases
    Washington University in St. Louis – St. Louis, Missouri, United States

    Group Leader – Molecular Infection Medicine
    Ume̴ University РUme̴, Sweden

    PhD Studentship – Chronic Skin Infections
    Ulster University – Belfast, Northern Ireland, United Kingdom

    Assistant/Associate Professor – Transplant Infectious Disease
    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    > See All Jobs

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