Disparate Impact of Oxidative Host Defenses Determines the Fate of Salmonella during Systemic Infection in Mice Researchers used single-cell approaches to determine the impact of oxidative and nitrosative stresses on individual Salmonella during early infection in mouse spleen. Salmonella encounter and respond to both stresses, but the levels and impact vary widely. [Cell Host Microbe] Full Article | Graphical Abstract Cellular Inhibitor of Apoptosis Protein cIAP2 Protects against Pulmonary Tissue Necrosis during Influenza Virus Infection to Promote Host Survival Investigators find that mice deficient in cellular inhibitors of apoptosis protein2 (cIAP2) exhibit increased susceptibility and mortality to influenza A virus infection. The lethality was not due to impaired antiviral immune functions, but rather because of death-receptor-induced programmed necrosis of airway epithelial cells that led to severe bronchiole epithelial degeneration, despite control of viral replication. [Cell Host Microbe] Abstract | Graphical Abstract | Press Release Role of Th1/Th17 Balance Regulated by T-bet in a Mouse Model of Mycobacterium avium Complex Disease Scientists identified that the fine balance between Th1 and Th17 responses is essential in defining the outcome of Mycobacterium avium complex (MAC) disease. T-bet functions as a regulator for Th1/Th17 balance and is a critical determinant for host resistance to MAC infection by controlling cytokine and NO levels. [J Immunol] Abstract Regulatory Role of CD4+CD25+Foxp3+ Regulatory T Cells on IL-17-Secreting T Cells in Chronic Hepatitis B Patients The frequencies of CD4+CD25+Foxp3+ T regulatory (Treg) cells and interleukin (IL)-17-secreting T cells in hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) patients and healthy subjects were measured by flow cytometric analysis. The role of Treg cells on the differentiation of Ag-specific IL-17-secreting T cells was determined by removing the Treg cells from peripheral blood mononuclear cells in HBeAg-positive CHB patients. [Dig Dis Sci] Abstract HIV Role of Protease Inhibitor 9 in Survival and Replication of Mycobacterium tuberculosis in Mononuclear Phagocytes from HIV-1-Infected Patients Researchers studied the contribution of protease inhibitor 9 to successful Mycobacterium tuberculosis infection of monocytes from HIV-1-infected patients. [AIDS] Abstract Specific Loss of Cellular L-Selectin on CD4+ T Cells Is Associated with PML Development during HIV Infection The authors discovered that HIV+ progressive multifocal leukoencephalopathy (PML) patients had a significantly lower expression of CD62L on CD4+ T cells when compared with HIV+ patients who did not develop PML. [AIDS] Abstract CD8+ T Cells Are Activated in an Antigen-Independent Manner in HIV-Infected Individuals Scientists report that CD8+ T cells were activated during in vivo HIV-1 replication irrespective of their Ag specificity. Cytokines present during untreated HIV-1 infection, most prominently IL-15, triggered proliferation and expression of activation markers in CD8+ T cells, but not CD4+ T cells, in the absence of TCR stimulation. [J Immunol] Abstract Exome Analysis of HIV Patients Submitted to Dendritic Cells Therapeutic Vaccine Reveals an Association of CNOT1 Gene with Response to the Treatment With the aim of searching genetic factors associated with the response to an immune treatment based on autologous monocyte-derived dendritic cells pulsed with autologous inactivated HIV, researchers performed exome analysis by screening more than 240,000 putative functional exonic variants in 18 HIV-positive Brazilian patients that underwent the immune treatment. [J Int AIDS Soc] Abstract |