Gut Microbiota Promote Hematopoiesis to Control Bacterial Infection The authors reveal that germ-free mice display reduced proportions and differentiation potential of specific myeloid cell progenitors of both yolk sac and bone marrow origin. Homeostatic innate immune defects may lead to impaired early responses to pathogens. [Cell Host Microbe] Abstract | Graphical Abstract | Press Release Extracellular ATP Affects the Response of Human Macrophages Infected with Mycobacterium tuberculosis Scientists showed that extracellular ATP indirectly modulates the expression of 272 genes in human macrophages infected with M. tuberculosis, and that it induces their alternative activation. [J Infect Dis] Abstract Dectin-1 Induces M1 Macrophages and Prominent Expansion of CD8+IL-17+ Cells in Pulmonary Paracoccidiodomycosis Paracoccidioides brasiliensis, the etiological agent of paracoccidioidomycosis, has a sugar-rich cell wall mainly composed of mannans and glucans. This fact motivated researchers to use dectin-1-sufficient and deficient mice to investigate the role of β-glucan recognition in the immunity against pulmonary paracoccidioidomycosis. [J Infect Dis] Abstract Combined Adenovirus Vector and Hepatitis C Virus Envelope Protein Prime-Boost Regime Elicits T Cell and Neutralizing Antibody Immune Responses To develop a hepatitis C virus (HCV) vaccine capable of inducing both T cell and antibody responses the authors constructed adenoviral vectors expressing full-length and truncated E1E2 envelope glycoproteins from HCV genotype 1b. [J Virol] Abstract Bordetella pertussis Proteins Dominating the MHC Class II-Presented Epitope Repertoire in Human Monocyte Derived Dendritic Cells Researchers for the first time elucidated dominant MHC class II-presented B. pertussis CD4+ T cell epitopes, expressed on human monocyte-derived dendritic cells after processing of whole bacterial cells, using a platform of immunoproteomics technology. [Clin Vaccine Immunol] Abstract HIV An Autoreactive Antibody from an SLE/HIV-1 Individual Broadly Neutralizes HIV-1 Researchers identified an HIV-1-infected individual with SLE who exhibited controlled viral load (< 5,000 copies/ml) in the absence of controlling HLA phenotypes and developed plasma HIV-1 neutralization breadth. [J Clin Invest] Full Article | Press Release Moderate Restriction of Macrophage-Tropic Human Immunodeficiency Virus Type 1 by SAMHD1 in Monocyte-Derived Macrophages Scientists showed that degradation of SAMHD1 in monocyte-derived macrophages was associated with moderately enhanced growth of the macrophage-tropic HIV-1 strain. SAMHD1 degradation was induced by treating target macrophages with vesicular stomatitis virus glycoprotein-pseudotyped human immunodeficiency virus type 2 particles containing viral protein X. [PLoS One] Full Article Innate DNA Sensing Is Impaired in HIV Patients and IFI16 Expression Correlates to Chronic Immune Activation The authors demonstrated impaired expression of interferon-stimulated genes in responses to DNA in PBMCs from HIV positive individuals, irrespective of whether patients receive antiretroviral treatment. [Clin Exp Immunol] Abstract Impact of HIV Co-Infection on Plasma Level of Cytokines and Chemokines of Pulmonary Tuberculosis Patients Investigators analyzed ex vivo plasma samples from 17 HIV negative and 16 HIV pulmonary tuberculosis co infected cases using Luminex assay to see impact of HIV co-infection on plasma level of cytokines and chemokines of pulmonary tuberculosis patients before and after anti tuberculosis treatment. [BMC Infect Dis] Full Article |