Immunology of Infectious Disease News Volume 2.13 | Apr 9 2014

Gr-1^dimCD11b⁺ Immature Myeloid-Derived Suppressor Cells but Not Neutrophils Are Markers of Lethal Tuberculosis Infection in Mice
Researchers showed that in mice, tuberculosis progression is associated with the accumulation of cells that express neutrophilic markers Gr-1 and Ly-6G but do not belong to conventional neutrophils. [J Immunol] Abstract

Regulatory Phenotype, PD-1 and TLR3 Expression in T Cells and Monocytes from HCV Patients Undergoing Antiviral Therapy: A Randomized Clinical Trial
The authors aimed to clarify the response of peripheral T cells and monocytes in chronic hepatitis C patients with antiviral treatment. [PLoS One] Full Article

Interferon-Mediated Innate Immune Responses against Malaria Parasite Liver Stages
Using RNA sequencing, investigators showed that a rodent malaria liver-stage infection stimulates a robust innate immune response including type I interferon (IFN) and IFNγ pathways. [Cell Rep]
Abstract | Full Article | Graphical Abstract

HIV

Reduction of HIV Persistence following Transplantation in HIV-Infected Kidney Transplant Recipients
Investigators explored the impact of immunosuppressant therapy on peripheral blood measures of human immunodeficiency virus (HIV) persistence following kidney transplantation. [Am J Transplant]
Abstract | Press Release

Diverse Viral Glycoproteins as Well as CD4 Co-Package into the Same Human Immunodeficiency Virus (HIV-1) Particles
To determine if co-packaging occurs among different glycoproteins, researchers designed an assay that combines virion antibody capture and a determination of infectivity based on a luciferase reporter. [Retrovirology] Full Article

HIV-1 Tat Protein Induces PD-L1 (B7-H1) Expression on Dendritic Cells through TNF-α and TLR4 Mediated Mechanisms
The authors aimed to determine whether and how HIV-1 Tat protein, an immunosuppressive viral factor, induces the PD-1/PD-L1 co-inhibitory pathway on human dendritic cells. [J Virol] Abstract

HIV-1 Nef Impairs Key Functional Activities in Human Macrophages through CD36 Downregulation
Investigators showed that HIV-1 Nef protein may have a role in the strategies elaborated by HIV-1 to alter pathogen disease outcomes, by modulating CD36 expression in macrophages, favoring the onset of opportunistic infections in HIV-1 infected people. [PLoS One] Full Article

Mesenchymal Stromal Cells in the Antimicrobial Host Response of Hematopoietic Stem Cell Recipients with Graft-versus-Host Disease – Friends or Foes?
The authors focus on the available data from in vitro studies and animal models regarding the interaction of mesenchymal stromal cells with bacterial, viral, and fungal pathogens. [Leukemia] Abstract

Visit our reviews page to see a complete list of reviews in the infectious disease research field.

XBiotech Announces In-Licensing of Technology from Strox Biopharmaceuticals
XBiotech announced that it acquired the patent estate of Strox Biopharmaceuticals relating to antibody therapies for methicillin resistant Staphylococcus aureus. [XBiotech USA, Inc.] Press Release

Pediatrician and Pediatric Infectious Disease Specialist Joins Loyola University Health System
Nadia K. Qureshi, MD, has brought her expertise in pediatric infectious disease and general pediatrics to Loyola University Health System. She also is an assistant professor in the Department of Pediatrics at Loyola University Chicago Stritch School of Medicine. [Loyola University Health System] Press Release

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Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

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Professorship Position – Infectious Diseases and Tropical Medicine (Medical University of Vienna)

Postdoctoral Positions – Virus-Host Interactions and Liver Disease (University of Strasbourg)

Postdoctoral Position – Intestinal Mucosal Immunology and Inflammation (Universität Bern)

PhD Position – Virology (Hannover Medical School)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Postdoctoral Fellow – AIDS Research (Leidos Biomedical Research, Inc.)

Postdoctoral Fellow – Immunology of Infection (CNRS – Institute of Pharmacology and Structural Biology)

Faculty Position – Vaccine Immunology (Cornell University)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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