Bystander Chronic Infection Negatively Impacts Development of CD8+ T Cell Memory Researchers investigated whether bystander chronic infections impact differentiation of memory CD8+ T cells, the hallmark of protective immunity against intracellular pathogens. Chronic bystander infections impaired development of memory CD8+ T cells in several mouse models and humans. [Immunity] Abstract | Graphical Abstract | Press Release T Cells Kill Bacteria Captured by Transinfection from Dendritic Cells and Confer Protection in Mice Transinfected T cells produced high levels of proinflammatory cytokines and were able to protect mice from bacterial challenge following adoptive transfer. Thus, T lymphocytes can capture and kill bacteria in a manner reminiscent of innate immunity. [Cell Host Microbe] Abstract | Graphical Abstract Telbivudine Therapy May Shape CD4+ T Cell Response to Prevent Liver Fibrosis in Patients with Chronic Hepatitis B Researchers found the therapeutic responses to telbivudine were especially associated with up-regulation of T helper (Th) 1 and Th17, and down-regulation of regulatory T cells. [Liver Int] Abstract IFN-γ, but Not IL-17A, Is Required for Survival during Secondary Pulmonary Francisella tularensis Live Vaccine Stain Infection Researchers measured the number of CD4+ T cells producing interferon (IFN)-γ or interleukin (IL)-17 in the spleen and lungs of vaccinated mice on day four of the secondary response using intracellular cytokine staining in order to identify protective T cell subsets participating in the memory response. [Vaccine] Abstract The In Vivo Expressed Mycobacterium tuberculosis (IVE-TB) Antigen Rv2034 Induces CD4+ T-Cells that Protect against Pulmonary Infection in HLA-DR Transgenic Mice and Guinea Pigs The Rv2034 protein was highly immunogenic in HLA-DR3 transgenic mice and induced HLA-DR3 restricted interferon (IFN)-γ+/tumor necrosis factor+ and IFN-γ+ CD4+ T-cells, specific for an epitope encoded in peptide 31-50. [Vaccine] Abstract The CD4 T Cell Response to Respiratory Syncytial Virus Infection Murine studies indicate that the combined actions of regulatory factors such as CD4 regulatory T cells and interleukin-10 inhibit the inflammatory cytokine response and limit respiratory syncytial virus-induced disease. [Immunol Res] Abstract HIV Vaccine-Induced Myeloid Cell Population Dampens Protective Immunity to SIV Results indicate that vaccine-induced myeloid-derived suppressor cells (MDSCs) inhibit protective cellular immunity and suggest that preventing MDSC induction may be critical for effective AIDS vaccination. [J Clin Invest] Full Article Promiscuous Glycan Site Recognition by Antibodies to the High-Mannose Patch of gp120 Broadens Neutralization of HIV By measuring neutralization on an extended range of glycan site viral variants, researchers found that some broadly neutralizing monoclonal antibodies can use alternate N-linked glycans in the absence of the N332 glycan site and therefore neutralize a substantial number of viruses lacking the site. [Sci Transl Med] Abstract | Press Release HIV-1 Tat Affects the Programming and Functionality of Human CD8+ T Cells by Modulating the Expression of T-box Transcription Factors. CD8+ T cells were activated by TCR engagement in the presence or absence of Tat. Cytokine production, killing capacity, surface phenotype and expression of transcription factors important for T-cell programming were evaluated. [AIDS] Abstract Changes in Genital Tract Immune Cell Populations after Initiation of Intrauterine Contraception Researchers hypothesized that when compared to baseline, use of a hormonal intrauterine device (IUD) would alter HIV target cells (primarily CCR5+ CD4 cells) in the female genital tract more than a non-hormonal IUD. [Am J Obstet Gynecol] Abstract |