Neutrophils Prime a Long-Lived Effector Macrophage Phenotype that Mediates Accelerated Helminth Expulsion Investigators examined the role of innate cells in acquired resistance to the natural murine parasitic nematode, Nippostrongylus brasiliensis. Macrophages obtained from lungs as late as 45 days after N. brasiliensis inoculation were able to transfer accelerated parasite clearance to naive recipients. [Nat Immunol] Abstract Translocalized IgA Mediates Neutralization and Stimulates Innate Immunity Inside Infected Cells Scientists show that IgA is carried inside cells during virus infection, where it activates intracellular virus neutralization and innate immune signaling. IgA neutralizes adenovirus infection in a tripartite motif-containing protein 21- and proteasome-dependent manner in both human and mouse cells. [Proc Natl Acad Sci USA] Abstract Late Engagement of CD86 after Influenza Virus Clearance Promotes Recovery in a FoxP3+ Regulatory T Cell Dependent Manner Investigators found that antibody-mediated CD86 blockade in vivo after virus clearance led to a delay in recovery, characterized by increased numbers of lung neutrophils and inflammatory cytokines in airways and lung interstitium, but no change in conventional Influenza A virus-specific T cell responses. [PLoS Pathog] Full Article T Cell-Derived IL-4/IL-13 Protects Mice against Fatal Schistosoma mansoni Infection Independently of Basophils Using T cell-specific IL-4/IL-13-deficient mice and basophil-deficient Mcpt8Cre mice, scientists determined the contribution of Th2 cells and basophils for protective immunity against S. mansoni egg-induced pathology during the patent stage of infection. [J Immunol] Abstract HIV Early Mucosal Sensing of SIV Infection by Paneth Cells Induces IL-1β Production and Initiates Gut Epithelial Disruption Researchers utilized the SIV model of AIDS to assess the earliest host-virus interactions and mechanisms of inflammation and dysfunction in the gut, prior to CD4+ T cell depletion. [PLoS Pathog] Full Article | Press Release HIV-1 Induces B-Cell Activation and Class Switch Recombination via Spleen Tyrosine Kinase and C-Jun N-Terminal Kinase Pathways Investigators evaluated which signaling pathways are activated in primary B cells after a direct contact with HIV-1 particles in vitro using different kinase inhibitors. [AIDS] Abstract Infant HIV-1 gp120 Vaccination Elicits Robust and Durable Anti-V1V2 IgG Responses and Only Rare Envelope-Specific IgA Responses Infant responses to vaccines can be impeded by maternal antibodies and immune system immaturity. HIV envelope-specific antibody responses were evaluated in two completed pediatric vaccine trials. [J Infect Dis] Abstract | Full Article | Press Release Emergence of Individual HIV-Specific CD8 T Cell Responses during Primary HIV-1 Infection Can Determine Long-Term Disease Outcome Investigators assessed which particular HIV-specific CD8 T cell responses contribute to long-term control of HIV-1. [J Virol] Abstract Direct Interrogation of Viral Peptides Presented by the Class I HLA of HIV Infected T Cells Scientists pursued deep ligand sequencing as an alternative method of directly identifying those ligands that are epitopes presented to cytotoxic T lymphocytes by the class I human leukocyte antigens (HLA) of infected cells. [J Virol] Abstract Don’t forget to subscribe to our sister publications: Human Immunology News and Immune Regulation News! |