A Central Role for Notch in Effector CD8+ T Cell Differentiation Activated CD8+ T cells choose between terminal effector cell (TEC) or memory precursor cell fates. Investigators found that the signaling receptor Notch controls this ‘choice’. Notch promoted the differentiation of immediately protective TECs and was correspondingly required for the clearance of acute infection with influenza virus. [Nat Immunol] Abstract Staphylococcus aureus Infection Induces Protein A-Mediated Immune Evasion in Humans Acutely activated B cells, or plasmablasts, were analyzed to dissect the ongoing immune response to infection through the production of monoclonal antibodies. The B cells that were activated by infection had a highly limited response. [J Exp Med] Abstract | Press Release Modulation of CD112 by the Alphaherpesvirus gD Protein Suppresses DNAM-1-Dependent NK Cell-Mediated Lysis of Infected Cells Investigators report that the gD glycoprotein of the alphaherpesviruses pseudorabies virus and herpes simplex virus-2 displays previously uncharacterized immune evasion properties toward natural killer (NK) cells. Expression of gD during infection or transfection led to degradation and consequent down-regulation of CD112, a ligand for the activating NK receptor DNAX accessory molecule 1 (DNAM-1). [Proc Natl Acad Sci USA] Abstract Recovery from an Acute Infection in C. elegans Requires the GATA Transcription Factor ELT-2 Scientists established a Caenorhabditis elegans–Salmonella enterica model of acute infection and antibiotic treatment for studying biological changes during the resolution phase of an infection. Using whole genome expression profiles of acutely infected animals, they found that genes that are markers of innate immunity are down-regulated upon recovery, while genes involved in xenobiotic detoxification, redox regulation, and cellular homeostasis are up-regulated. [PLoS Genet] Full Article | Press Release Protection against Streptococcus pneumoniae Lung Infection after Nasopharyngeal Colonization Requires both Humoral and Cellular Immune Responses The authors show that naturally acquired protective immunity to S. pneumoniae lung infection requires both humoral and cell-mediated immune responses, providing a template for the design of improved vaccines that can specifically prevent pneumonia or acute bronchitis. [Mucosal Immunol] Full Article Conditional IL-4/IL-13-Deficient Mice Reveal a Critical Role of Innate Immune Cells for Protective Immunity against Gastrointestinal Helminths Scientists compared the immune response to Nippostrongylus brasiliensis in wild-type, T cell-specific interleukin (IL)-4/IL-13-deficient and general IL-4/IL-13-deficient mice. [Mucosal Immunol] Abstract CD8 T Cells in Innate Immune Responses: Using STAT4-Dependent but Antigen-Independent Pathways to Gamma Interferon during Viral Infection The authors provide novel insights into the endogenous regulation of cytokine and proliferative responses and demonstrate conditioning of innate immunity by experience. [mBio] Full Article | Press Release HIV A Gene-Specific Role for the Ssu72 RNAPII CTD Phosphatase in HIV-1 Tat Transactivation Chromatin immunoprecipitation experiments reveal that Ssu72, like positive transcription elongation factor-b and AFF4, is recruited by Tat to the integrated HIV-1 proviral promoter in TNF-α signaling 2D10 T cells and leaves the elongation complex prior to the termination site. [Genes Dev] Abstract | Press Release | Video Fetal Exposure to HIV-1 Alters Chemokine Receptor Expression by CD4+ T Cells and Increases Susceptibility to HIV-1 Researchers compared the expression of chemokine receptors on cord blood CD4+ T cells from uninfected infants born to HIV-1-infected women (HIV-1-exposed) and healthy controls. They assessed whether the inflammatory phenotype was associated with susceptibility to HIV-1 and detected higher levels of p24 upon in in vitro infection of stimulated CD4+ T cells of HIV-1-exposed infants. [Sci Rep] Full Article Complex TCR Repertoire Dynamics Underlie the CD8+ T-Cell Response to HIV-1 Scientists conducted a comprehensive analysis of viral sequence variation and T-cell receptor (TCR) repertoire composition across multiple epitope specificities in a group of antiretroviral treatment-naïve individuals chronically infected with HIV-1. [J Virol] Abstract MAIT Cells Are Depleted Early but Retain Functional Cytokine Expression in HIV Infection Scientists studied longitudinal blood samples from 31 HIV-infected subjects for mucosal-associated invariant T (MAIT) cell numbers, phenotype and function using both standard Vα7.2/CD161 surface markers and an MR1 tetramer. [Immunol Cell Biol] Abstract Don’t forget to subscribe to our sister publications: Human Immunology News and Immune Regulation News! |