Transmission of Innate Immune Signaling by Packaging of cGAMP in Viral Particles Scientists showed that in cells producing virus, cyclic GMP-AMP synthase-synthesized 2′3′-cyclic GMP-AMP (cGAMP) can be packaged in viral particles and extracellular vesicles. cGAMP transfer by viral particles to dendritic cells activated innate immunity and antiviral defenses. [Science] Abstract BNIP3- and BNIP3L-Mediated Mitophagy Promotes the Generation of Natural Killer Cell Memory The authors found that as proliferating natural killer cells accumulated dysfunctional mitochondria during viral infection, a protective mitophagy pathway was induced during the contraction phase to promote their survival in a reactive oxygen species-dependent manner. [Immunity] Abstract | Graphical Abstract Protection against Dengue Disease by Synthetic Nucleic Acid Antibody Prophylaxis/Immunotherapy Scientists demonstrated that simple intramuscular delivery by electroporation of synthetic DNA plasmids engineered to express modified human neutralizing antibodies against multiple dengue virus (DENV) serotypes confers protection against DENV disease and prevents antibody-dependent enhancement of disease in mice. [Sci Rep] Full Article | Press Release Modulation of Influenza Vaccine Immune Responses Using an Epidermal Growth Factor Receptor Kinase Inhibitor Researchers hypothesized that epidermal growth factor receptor inhibitors (EGFRIs) may have value as cutaneous immune response modifiers, and determined the effects of topical application of an irreversible EGFRI on a well-established murine model of influenza vaccination. [Sci Rep] Full Article HIV Diversion of HIV-1 Vaccine–Induced Immunity by gp41-Microbiota Cross-Reactive Antibodies Researchers studied the nature of the vaccine-induced antibody (Ab) response to HIV-1 envelope (Env). HIV-1-reactive plasma Ab titers were higher to Env gp41 than gp120, and repertoire analysis demonstrated that 93% of HIV-1-reactive Abs from memory B cells was to Env gp41. [Science] Abstract | Press Release Quality and Quantity of TFH Cells Are Critical for Broad Antibody Development in SHIVAD8 Infection Researchers used nonhuman primates to investigate the relationship in the early stage of chronic SHIVAD8 (simian-human immunodeficiency virus AD8) infection between envelope (Env)–specific T follicular helper (TFH) cells, Env-specific B cells, virus, and the generation of broadly neutralizing antibodies during later infection. [Sci Transl Med] Abstract Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation Investigators report that PEP005, the only active component in a previously FDA approved drug for the topical treatment of precancerous actinic keratosis, can effectively reactivate latent HIV in vitro and ex vivo with relatively low cellular toxicity. [PLoS Pathog] Full Article | Press Release Elite Control, Gut CD4 T Cell Sparing, and Enhanced Mucosal T Cell Responses in Macaca nemestrina Infected by an SIV Lacking a gp41 Trafficking Motif In pig-tailed macaques ΔGY replicated acutely to high peak plasma RNA levels identical to SIVmac239, and caused only transient infection of CD4+ T cells in the gut lamina propria and no microbial translocation. [J Virol] Abstract Innate Immune Activity Correlates with CD4 T Cell-Associated HIV-1 DNA Decline during Latency-Reversing Treatment with Panobinostat The authors analyzed immune factors associated with changes in proviral HIV-1 DNA levels during treatment with the potent histone deacetylase inhibitor panobinostat in a human clinical trial involving 15 antiretroviral combination therapy-treated HIV-1 patients. [J Virol] Abstract Subscribe to our sister publications: Human Immunology News and Immune Regulation News! |