In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity Researchers used two-photon microscopy to quantify cytotoxic T lymphocyte (CTL)-mediated killing in mice infected with herpesviruses or poxviruses. During killing, CTLs remained migratory and formed motile kinapses rather than static synapses with targets. [Immunity] Abstract | Graphical Abstract Genomic Modifiers of Natural Killer Cells, Immune Responsiveness and Lymphoid Tissue Remodeling Together Increase Host Resistance to Viral Infection Scientists applied genomic mapping strategies and multicolor flow cytometric analysis of immune cells in naive and virus-infected hosts to identify genetic modifiers of the host immune response to murine cytomegalovirus. [PLoS Pathog] Full Article | Press Release IL-4-Producing ILC2s Are Required for the Differentiation of TH2 Cells following Heligmosomoides polygyrus Infection Using H. polygyrus, which is controlled by IL-4-dependent immunity, researchers identified that group-2 innate lymphoid cells (ILC2s) produced significant amounts of IL-4 and IL-2 following H. polygyrus infection. [Mucosal Immunol] Full Article IGHV1-69 Polymorphism Modulates Anti-Influenza Antibody Repertoires, Correlates with IGHV Utilization Shifts and Varies by Ethnicity Researchers studied a cohort of NIH H5N1 vaccinees and demonstrate for the first time the influence of IGHV1‑69 polymorphism on V-segment usage, somatic hypermutation and B cell expansion that elucidates the dominance of F-alleles in HV1-69-sBnAbs. [Sci Rep] Full Article | Press Release Cryptococcus neoformans Thermotolerance to Avian Body Temperature Is Sufficient for Extracellular Growth but Not Intracellular Survival In Macrophages Scientists found that bird macrophages are able to suppress the growth of cryptococci seen in mammalian cells despite C. neoformans being able to grow at bird body temperature, and are able to escape from bird macrophages by vomocytosis. [Sci Rep] Full Article | Press Release HIV Fc Receptor-Mediated Phagocytosis in Tissues as a Potent Mechanism for Preventive and Therapeutic HIV Vaccine Strategies Scientists aimed to define the landscape of effector cells and Fc receptors present within vulnerable tissues. They found negligible Fc receptor-expressing natural killer cells in the female reproductive and gastrointestinal mucosa. [Mucosal Immunol] Abstract CCR6− Regulatory T Cells Blunt the Restoration of Gut Th17 Cells along the CCR6–CCL20 Axis in Treated HIV-1-Infected Individuals Investigators showed that the CCR6–CCL20 chemotactic axis is altered, with reduced CCL20 production by small intestine epithelial cells in treated HIV-1-infected individuals. This leads to impaired CCR6+CD4+ T-cell homing, particularly T helper type 17 (Th17) cells, to the small intestine mucosa. [Mucosal Immunol] Abstract Streamlining Heterologous DNA-Prime and NYVAC/Protein-Boost HIV Vaccine Regimens in Rhesus Macaques by Employing Improved Antigens Investigators assessed in non-human primates whether such vaccination regimens can be further streamlined using fewer and accelerated immunizations when employing a novel generation of improved DNA-C and NYVAC-C vaccine candidates designed for higher expression levels and more balanced immune responses. [J Virol] Abstract Subscribe to our sister publications: Human Immunology News and Immune Regulation News! |