Immunology of Infectious Disease News 4.20 May 25, 2016 | |
| |
TOP STORYImpact of Pre-Adapted HIV Transmission Scientists demonstrated that transmission of viruses that are pre-adapted to the human leukocyte antigen class I molecules expressed in the recipient is associated with impaired immunogenicity, elevated viral load and accelerated CD4+ T cell decline. [Nat Med] Abstract | Press Release | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling Researchers report that the nonstructural protein NS5 of Zika virus and other flaviviruses examined could suppress interferon signaling, but through different mechanisms. [Cell Host Microbe] Full Article | Graphical Abstract | Press Release Investigators evaluated the safety, tolerability and efficacy of GS-4774 in patients with chronic hepatitis B virus infection. [J Hepatol] Abstract Hepatitis B Virus Inhibits Intrinsic RIG-I and RIG-G Immune Signaling via Inducing miR146a Scientists observed that down-regulated RIG-I like receptors might be one critical mechanism of hepatitis B virus (HBV)-induced suppression of type I IFN transcription in both HBV+ hepatoma cell lines and liver cancer tissues. [Sci Rep] Full Article Selection of Antigenically Advanced Variants of Seasonal Influenza Viruses To establish experimental approaches that may complement the current vaccine strain selection process, scientists selected antigenic variants from human H1N1 and H3N2 influenza virus libraries possessing random mutations in the globular head of the hemagglutinin protein (which includes the antigenic sites) by incubating them with human and/or ferret convalescent sera to human H1N1 and H3N2 viruses. [Nat Microbiol] Abstract | Press Release HIVInvestigators evaluated the potential of DC-mediated immunization with a DNA vaccine consisting of HIV-1-p55gag (gag, group-specific antigen) associated to lysosomal associated protein sequence. [FASEB J] Abstract Scientists investigated the in vitro and systemic in vivo effect of panobinostat, a clinically relevant histone deacetylase inhibitor, on HIV latency. [Retrovirology] Full Article Researchers longitudinally measured plasma levels of B-tropic chemokines by ELISA-based technology as well as their ligands by flow-cytometry on blood B-cell populations of HIV-1-infected individuals with different rates of disease progression and uninfected controls. [PLoS One] Full Article Excision of HIV-1 DNA by Gene Editing: A Proof-of-Concept In Vivo Study Investigators employed a short version of the Cas9 endonuclease, saCas9, together with a multiplex of guide RNAs for targeting the viral DNA sequences within the 5′-LTR and the Gag gene for removing critically important segments of the viral DNA in transgenic mice and rats encompassing the HIV-1 genome. [Gene Ther] Abstract Subscribe to out sister publications: Human Immunology News & Immune Regulation News. | |
| |
REVIEWSAging and Inflammation in Patients with HIV Infection The authors discussed the role of inflammation and immune activation on the most important non-AIDS related complications of chronic HIV infection, and the contribution of aging per se to this scenario. [Clin Exp Immunol] Abstract | Full Article Visit our reviews page to see a complete list of reviews in the immunology of infectious disease research field.
| |
SCIENCE NEWSFlu Vaccination Associated with Lower Dementia Risk in Patients with Heart Failure Influenza vaccination is associated with a lower risk of dementia in patients with heart failure, according to a study in more than 20000 patients [Press release from the European Society of Cardiology (EurekAlert) discussing research presented at 3rd World Congress on Acute Heart Failure, Taipei] Press Release | |
From our sponsor: Free human hematopoietic progenitors wallchart. Request your copy.
| |
INDUSTRY NEWSLarge-Scale HIV Vaccine Trial to Launch in South Africa An early-stage HIV vaccine clinical trial in South Africa has determined that an investigational vaccine regimen is safe and generates comparable immune responses to those reported in a landmark 2009 study showing that a vaccine can protect people from HIV infection. [National Institutes of Health] Press Release Theratechnologies Inc. announced that it has been notified by its partner, TaiMed Biologics, Inc., of the preliminary results for the primary end point of the Phase III trial with ibalizumab in patients with multi-drug resistant HIV-1 (TMB-301). [Theratechnologies] Press Release
| |
EVENTSNEW 10th Australasian Viral Hepatitis 2016 Conference Visit our events page to see a complete list of events in the immunology of infectious disease community.
| |
JOB OPPORTUNITIESNEW Research Fellow – Structural Molecular Virology (University of Leeds) Research Associate – Immunology and Cell Separation (STEMCELL Technologies Inc.) Scientific Communications and Publishing Coordinator (STEMCELL Technologies Inc.) Research Technologist – T Cell Immunology (STEMCELL Technologies Inc.) Research Technologist – Cell Separation (STEMCELL Technologies Inc.) Scientist – Bioengineering (STEMCELL Technologies Inc.) Senior Scientist – Immunology and Cell Separation (STEMCELL Technologies Inc.) Postdoctoral Research Fellow – Immune Response to Infection (Fred Hutchinson Cancer Research Center) Principal Investigators – Infectious Diseases (CCID) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Immunology of Infectious Disease News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|
Home Immunology of Infectious Disease News Volume 4.20 | May 25 2016