Immunology of Infectious Disease News Volume 4.23 | Jun 15 2016

TOP STORY

Nonclassical MHC Ib-Restricted CD8⁺ T Cells Recognize Mycobacterium tuberculosis-Derived Protein Antigens and Contribute to Protection against Infection

Investigators used mice that lack MHC Ia, MHC Ia/H2-M3, or β₂m to study the role of M3-restricted and other MHC Ib-restricted T cells in immunity against M. tuberculosis. [PLoS Pathog] Full Article

(Ranked by impact factor of the journal)

Co-Infection with Human CMV Genetic Variants in Transplant Recipients and Its Impact on Anti-Viral T Cell Immunity

Investigators evaluated dynamic changes in the emergence of genetic variants of cytomegalovirus (CMV) in hematopoietic stem cell transplant recipients and correlated these changes with reconstitution of anti-viral T cell responses. [J Virol] Abstract

Remodeling of B-Cell Subsets in Blood during Pegylated IFNα-2a Therapy in Patients with Chronic Hepatitis B Infection

Scientists investigated here the effects of pegylated interferon-α-2a (Peg-IFN-α) on eight circulating B-cell subsets thanks to an original multi-gating approach based on CD19, CD27, IgD, CD10, and CD38 markers in patients with chronic hepatitis B treated with nucleos(t)ide analog alone or in combination with Peg-IFN-α. [PLoS One] Full Article

Infection with the Persistent Murine Norovirus Strain MNV-S99 Suppresses IFN-Beta Release and Activation of Stat1 In Vitro

Scientists showed that the murine norovirus (MNV) strain MNV-S99 persists in wild type inbred (C57BL/6J) mice over a period of at least five weeks post infection. [PLoS One] Full Article

Alcohol Intake Alters Immune Responses and Promotes CNS Viral Persistence in Mice

Researchers investigated the role of alcohol in regulating viral persistence and central nervous system (CNS) immunopathology in mice infected with lymphocytic choriomeningitis virus, a model for hepatitis C virus infections in humans. [Behav Brain Res] Abstract

HIV

Sequential Dysfunction and Progressive Depletion of Candida albicans-Specific CD4 T Cell Response in HIV-1 Infection

Based on an antiretroviral treatment naïve HIV infection cohort, scientists investigated longitudinally the impact of HIV on C. albicans– and CMV-specific CD4 T-cell immunity in vivo. [PLoS Pathog] Full Article | Press Release

Elimination of Latently HIV-Infected Cells from Antiretroviral Therapy-Suppressed Subjects by Engineered Immune-Mobilizing T Cell Receptors

Scientists tested the antiviral efficacy of immune-mobilizing monoclonal T cell receptors against viruses, bispecifc molecules that re-direct CD8⁺ T cells to kill HIV-infected CD4⁺ T cells. [Mol Ther] Abstract | Press Release

Polymorphisms in the CD14 and TLR4 Genes Independently Predict CD4⁺ T-Cell Recovery in HIV-Infected Individuals on Antiretroviral Therapy

Scientists hypothesized that single-nucleotide polymorphisms in genes encoding the Toll-like receptor 4 (TLR4) and CD14, the principal receptors for lipopolysaccharide, were associated with CD4⁺ T-cell recovery post-antiretroviral therapy. [AIDS] Abstract

HIV-Tat Immunization Induces Cross-Clade Neutralizing Antibodies and CD4⁺ T Cell Increases in Antiretroviral-Treated South African Volunteers: A Randomized Phase II Clinical Trial

To assess whether B-clade transactivator of transcription (Tat) immunization would be effective also in patients with different genetic background and infecting virus, a Phase II trial was conducted in South Africa. [Retrovirology] Full Article

Subscribe to our sister publications: Human Immunology News & Immune Regulation News.

Antigenic Landscape of the HIV-1 Envelope and New Immunological Concepts Defined by HIV-1 Broadly Neutralizing Antibodies

The authors review recent advances in crystal structural determinations of HIV-1 broadly neutralizing antibodies epitopes that directly portray the antigenic landscape of the HIV-1 envelope glycoprotein. [Curr Opin Immunol] Abstract

Discordant Immune Response with Antiretroviral Therapy in HIV-1: A Systematic Review of Clinical Outcomes

The authors summarize the risk of mortality, AIDS and serious non-AIDS events associated with discordant immune response with a systematic review. [PLoS One] Full Article

Visit our reviews page to see a complete list of reviews in the immunology of infectious disease research field.

Genocea Showcases Potential of Genital Herpes Immunotherapy GEN-003

Genocea Biosciences, Inc. will present updated data on the company’s investigational immunotherapies. [Press release from Genocea Biosciences, Inc. discussing research presented at American Society for Microbiology Annual General Meeting, Boston] Press Release

NIH Awards Emory $35.6 Million Grant for Research Aimed at HIV/AIDS Vaccine and Cure

A research consortium Emory University is leading has been awarded a five-year, $35.6 million grant from the National Institutes of Health to develop new strategies for preventing and curing HIV/AIDS. [Emory University] Press Release

Cepheid Announces World Health Organization Prequalification Of Xpert HIV-1 Qualitative Test

Cepheid announced that its Xpert^® HIV-1 Qual (Qualitative) test has been awarded World Health Organization prequalification, making it one of the first molecular point of care tests designed for HIV to be given this designation. [Cepheid] Press Release

NEW British HIV Association (BHIVA) Autumn Conference 2016
October 13-14, 2016
London, United Kingdom

Visit our events page to see a complete list of events in the immunology of infectious disease community.

NEW Assistant, Associate, and Full Professor – Infectious Diseases (University of Washington)

Research Associate – Immunology and Cell Separation (STEMCELL Technologies Inc.)

Research Technologist – T Cell Immunology (STEMCELL Technologies Inc.)

Research Technologist – Cell Separation (STEMCELL Technologies Inc.)

Scientist – Bioengineering (STEMCELL Technologies Inc.)

Senior Scientist – Immunology and Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Molecular and Cellular Biology of Inflammation (King’s College London)

Postdoctoral Scientist – Immune Focused In Vitro Research (King’s College London)

Postdoctoral Research Fellow – HIV Vaccine Research (Universitätsklinikum Essen)

Pharmacologist/Toxicologist (The National Institute of Allergy and Infectious Diseases)

Postdoctoral Research Fellow – Immune Response to Infection (Fred Hutchinson Cancer Research Center)

Principal Investigators – Infectious Diseases (CCID)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Immunology of Infectious Disease News? Click here to submit!

Comments or suggestions? Submit your feedback here.