Immunology of Infectious Disease News 5.30 August 2, 2017 | |
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TOP STORYNon-Neutralizing Antibodies Alter the Course of HIV-1 Infection In Vivo To investigate the role of non-neutralizing antibodies on HIV-1 infection in vivo, scientists devised a replication-competent HIV-1 reporter virus that expresses a heterologous HA-tag on the surface of infected cells and virions. Anti-HA antibodies bound to, but do not neutralize, the reporter virus in vitro. [Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Hepatitis B virus (HBV)-specific T cells lysed HBV-producing hepatoma cells in vitro. In vivo, three injections of HBV-specific T cells caused progressive viremia reduction within 12 days of treatment in animals reconstituted with haplotype-matched hepatocytes, whereas viremia remained stable in mice receiving irrelevant T cells redirected toward hepatitis C virus–specific T cell receptors. [J Clin Invest] Full Article The authors determined the blockade of dengue virus (DENV) infection by targeting endocytic pathways in vitro and in vivo. DENV caused infection, including entry, double-stranded RNA replication, protein expression, and virus release, followed by cytotoxicity in the mouse neuronal Neuro-2a cell line. [Sci Rep] Full Article Antibodies against Modified NS1 Wing Domain Peptide Protect against Dengue Virus Infection Investigators found that both monoclonal Ab 33D2 and modified nonstructural protein-1 (NS1)-wing domain peptide immune sera could induce complement-dependent lysis of dengue-infected but not uninfected cells in vitro. [Sci Rep] Full Article Researchers examined the role of the IL-1 receptor/Toll-like receptor (IL-1R/TLR) signaling pathway in adaptive immune responses and viral clearance by exploring the hepatitis B virus mouse model. [Cell Mol Immunol] Full Article Using a knockout mouse line engineered to express green fluorescent protein under the serpbinb9 promoter, investigators demonstrated that serpinb9 is vital for host survival during Ectromelia virus infection by maintaining both mature NK cells, and activated CD8+ T cells. [Immunol Cell Biol] Abstract Researchers showed that M. tuberculosis-specific CD4 T-cell functional profile of tuberculosis patients from Tanzania are primarily composed of polyfunctional Th1 and Th2 cells, associated with increased expression of Gata-3 and reduced expression of T-bet in memory CD4 T cells. [PLoS Negl Trop Dis] Full Article Using an intravenous disseminated infection mouse model, scientists observed that more CD8+ T cells than CD4+ T cells were present in the spleen of infected mice at 12 days post-infection (dpi). They also determined that Treg cells and the proportion of T cells producing IL-10 were significantly increased from 6 dpi, which correlated with the onset of illness, body weight loss, and increased bacterial loads. [PLoS Negl Trop Dis] Full Article The authors showed a reduction in the recovery of replication-competent virus from vorinostat exposed resting CD4 T cells following addition of immune effectors for a discrete period. [EBioMedicine] Full Article | Press Release HIVHIV infection was associated with a lower total frequency of cytokine-producing M. tuberculosis-specific CD4 T cells, and preferential depletion of a discrete subset of M. tuberculosis-specific IFN-γ+IL-2−TNF-α+ CD4 T cells. [J Immunol] Abstract Subscribe to our sister publications: Human Immunology News & Immune Regulation News. | |
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REVIEWSThe Immunopathology of Dengue and Zika Virus Infections The authors examine the role immunopathogenesis plays during dengue virus (DENV) infection as well as highlighting recent studies that demonstrate DENV immunity may have an effect on the outcome of Zika virus infection. [Curr Opin Immunol] Abstract Visit our reviews page to see a complete list of reviews in the immunology of infectious disease research field. | |
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SCIENCE NEWSViiV Healthcare announced positive interim results from DAWNING. This is a non-inferiority study conducted to compare second-line treatment of the protease inhibitor-sparing regimen of dolutegravir and two nucleoside reverse transcriptase inhibitors (NRTIs), with a current WHO-recommended regimen of lopinavir/ritonavir and two NRTIs in HIV-1-infected adults. [Press release from GlaxoSmithKline plc. discussing research to be presented at the 2017 International AIDS Society Congress, Paris] Press Release | |
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INDUSTRY NEWSShionogi & Co., Ltd. announced that S-033188, a novel cap-dependent endonuclease inhibitor targeting influenza, demonstrated superiority to placebo in a global Phase III study in otherwise healthy patients. [Shionogi & Co., Ltd.] Press Release Eiger BioPharmaceuticals, Inc. announced that the FDA has granted Fast Track designation for pegylated interferon lambda 1a as a potential treatment for chronic hepatitis delta virus infection. [Eiger BioPharmaceuticals, Inc.] Press Release Gilead Sciences, Inc. announced that the FDA has approved updated labeling for Epclusa®, the first all-oral, pan-genotypic, once-daily single tablet regimen for the treatment of adults with chronic hepatitis C virus infection, to include use in patients co-infected with HIV. [Gilead Sciences, Inc.] Press Release Integrated BioTherapeutics Inc. announced that it has been awarded a $6.6 million grant by the National Institute of Allergy and Infectious Diseases to develop a vaccine that can protect against all ebolaviruses. [Integrated BioTherapeutics Inc. (PR Newswire Association LLC.)] Press Release | |
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EVENTSNEW 19th Annual International Meeting of the Institute of Human Virology Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Junior Professorship – Systems Biology of Human Parasites (Universität Hamburg) Senior Bioinformatician – Malaria Genomics (Wellcome Trust Sanger Institute) Mouse Scientist – T Cell-Based Therapy (Tessa Therapeutics Pte. Ltd.) Full Faculty Member – Immunology (Fred Hutchinson Cancer Research Center) Research Fellow – HIV/AIDS Research (Dana-Farber Cancer Institute) Assistant/Associate Professor – Disease-Specific Immunology/Vaccinology (Brown University) Postdoctoral Position – Cell Biology and Innate Immunity (Molecular Infection Medicine Sweden) Lab Aide – Infectious Disease Sciences Program (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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