Immunology of Infectious Disease News 6.17 May 2, 2018 | |
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TOP STORYThe authors investigated mechanisms by which hepatitis C virus (HCV) modulates chemokine-mediated intercellular communication of the infected cells. [J Hepatol] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)This exploratory randomized, double-blind, placebo-controlled trial evaluated an immunotherapeutic vaccine containing a recombinant Candida albicans adhesin/invasin protein for prevention of recurrent vulvovaginal candidiasis. [Clin Infect Dis] Abstract | Press Release The authors report that STING-activating cyclic dinucleotides formulated in a protein subunit vaccine elicit long-lasting protective immunity to Mycobacterium tuberculosis in the mouse model. Intranasal delivery resulted in superior protection compared with Bacille Calmette-Guérin (BCG), significantly boosted BCG-based immunity, and elicited both Th1 and Th17 immune responses, the latter of which correlates with enhanced protection. [Cell Rep] Full Article | Graphical Abstract Scientists used a novel HIV reporter strain in primary CD4+ T cells and determined which latently infected cells are reactivatable by current candidate latency-reversing agents. [eLife] Abstract | Press Release Cross-Sectional Analysis of CD8 T Cell Immunity to Human Herpesvirus 6B Investigators undertook a virus-wide analysis of CD8 T cell responses to human herpesvirus 6 (HHV-6). From peptide-expanded T cell lines, they obtained CD8 T cell clones against 20 candidates. They tested whether T cell clones recognized HHV-6-infected cells. [PLoS Pathog] Full Article | Press Release Researchers developed an in vitro model aiming to mimic mucosal HIV transmission via infected cells. PHA-activated CD4+ T cells stained with PKH26 from donor A were infected and co-cultured with CD4+ T cells and dendritic cells from donor B in the presence of broadly neutralizing antibodies. [AIDS] Abstract Human T Lymphocytes Are Permissive for Dengue Virus Replication Investigators demonstrated that primary human naive CD4+ and CD8+ T cells are permissive for dengue virus (DV) infection. DV infection triggered the activation of both CD4+ and CD8+ T lymphocytes, but preactivation of T cells reduced the susceptibility of T cells to DV infection. [J Virol] Abstract Dynamics of Tissue-Specific CD8+ T Cell Responses during West Nile Virus Infection The authors present the characterization of a T cell receptortransgenic mouse with specificity for the immunodominant epitope in the West Nile virus (WNV) NS4B protein (here referred to as transgenic WNV-I mice). Using an adoptive-transfer model, they found that WNV-I CD8+ T cells behaved similarly to endogenous CD8+ T cell responses, with an expansion phase in the periphery beginning around day 7 postinfection (p.i.) followed by a contraction phase through day 15 p.i. [J Virol] Abstract Scientists demonstrated that a conserved cryptic epitope that is unrecognized by the host immune system following infection can protect mice following vaccination, and that immunity is strengthened and broadened following successive infections. [Sci Rep] Full Article Subscribe to our sister publications: Human Immunology News & Immune Regulation News. | |
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REVIEWSCan Broadly Neutralizing Monoclonal Antibodies Lead to a Hepatitis C Virus Vaccine? Recent high-resolution broadly neutralizing human monoclonal antibodie (bNAb) epitope mapping and structural analysis of bNAb-epitope complexes that may serve as a guide for vaccine development are discussed along with major obstacles. [Trends Microbiol] Abstract Visit our reviews page to see a complete list of reviews in the immunology of infectious disease research field. | |
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INDUSTRY NEWSA $15-million gift from the visionary Montreal-based Doggone Foundation will launch the McGill Interdisciplinary Initiative in Infection and Immunity, a unique and highly collaborative endeavour that will harness the scientific expertise, resources and creativity of researchers at McGill, the McGill University Health Centre and affiliated research partners in the battle against infectious and immune-related diseases. [McGill University] Press Release Statement on New Universal Flu Vaccine Development Grand Challenge The new $12 million “Ending the Pandemic Threat: A Grand Challenge for Universal Influenza Vaccine Development” from the Bill & Melinda Gates Foundation and Lucy and Larry Page is an important and necessary step toward finding a game-changing solution to end the threat of flu, according to experts at the Sabin Vaccine Institute, a leading advocate for expanding vaccine access and uptake across the world. This challenge invites researchers from any discipline to submit innovative ideas for safe, effective, affordable flu vaccines. [Sabin Vaccine Institute] Press Release 1 | Press Release 2 Dr. Paul Offit Receives 2018 Albert B. Sabin Gold Medal The Sabin Vaccine Institute has awarded Paul Offit, MD, of Children’s Hospital of Philadelphia, the 2018 Albert B. Sabin Gold Medal. Sabin recognized Dr. Offit as co-inventor of an oral rotavirus vaccine and for his leadership as one of the United States’ most vocal and dedicated advocates for immunization. [Sabin Vaccine Institute] Press Release NFID Recognizes Infectious Disease Heroes and Calls for 2019 Awards Nominations To mark its 45th anniversary, the National Foundation for Infectious Diseases (NFID) will celebrate three infectious disease heroes during the 2018 annual awards dinner, at the historic Willard InterContinental Washington, D.C. [National Foundation for Infectious Diseases] Press Release | |
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POLICY NEWSThe Trump Administration’s proposal to slash funding to fight global health threats like malaria, Ebola, and HIV/AIDS could cost states thousands of jobs and millions of dollars in economic investment and put the health of residents at risk, according to a new state-by-state analysis released on Capitol Hill by the Global Health Technologies Coalition. [Global Health Technologies Coalition] Editorial Harassment and Discrimination Allegations Roil a Top US Biomedical Institute Allegations of sexual harassment and assault levelled against Inder Verma, a prominent cancer biologist at the Salk Institute for Biological Studies in La Jolla, California, cap a tumultuous ten months for the well-known research centre. [Nature News] Editorial Science in North Korea: How Easing the Nuclear Stand-Off Might Bolster Research The isolated nation publishes fewer than 100 scholarly articles a year — but as political tensions thaw, researchers hope for greater collaboration. [Nature News] Editorial Prominent Cell Biologist Fired after Data Manipulation Investigation A University of Tokyo scientist known for his work on cell division has been fired, Retraction Watch reports. The university announced the “disciplinary dismissal” in a statement released. [The Scientist] Editorial
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EVENTSNEW Keystone Symposia: Molecular Approaches to Vaccines and Immune Monitoring Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Faculty Positions – Infectious Disease Research (Institut Pasteur of Shanghai) Research Technologist – Cell Separation (STEMCELL Technologies Inc.) Postdoctoral Research Fellow/Junior Scientist – Pathogen Genomics (Fudan University) Postdoctoral Research Scientist – HIV Vaccine Design (Simon Fraser University) Postdoctoral Associate – Infectious Disease (Research Foundation for SUNY) Director of Biomarkers & Assays – Infectious Diseases Research (Moderna Therapeutics) Research Associate – Vaccine Research (University of Bristol) Senior Research Associate – Infectious Disease (Moderna Therapeutics) Assistant/Associate Professor – Virology (Saint Louis University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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