Immunology of Infectious Disease News 6.30 August 1, 2018 | |
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TOP STORYImmune Responses to MERS Coronavirus during the Acute and Convalescent Phases of Human Infection The authors investigated the spectrum of immune responses occurring in patients with Middle East respiratory syndrome (MERS) during the early period of infection. [Clin Infect Dis] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)IRF-5 Promotes Cell Death in CD4 T Cells during Chronic Infection Investigators demonstrated that interferon regulatory factor 5 (IRF-5) was increasingly expressed in interferon-γ+ CD4 T cells over the course of Leishmania donovani infection. [Cell Rep] Full Article | Graphical Abstract | Press Release The Induction of IL-1β Secretion Through the NLRP3 Inflammasome during Ebola Virus Infection Researchers demonstrated that Ebola virus infection leads to the activation of the NLRP3 inflammasome and the subsequent secretion of IL-1β and IL-18. [J Infect Dis] Abstract Inflammatory Response of Microglia to Prions Is Controlled by Sialylation of PrPSc Scientists found that exposure of BV2 cells or primary microglia to purified PrPSc triggered proinflammatory responses characterized by an increase in the levels of TNFα, IL6, nitric oxide and expression of inducible nitric oxide synthase. [Sci Rep] Full Article Cotton Rat Lung Transcriptome Reveals Host Immune Response to Respiratory Syncytial Virus Infection Cotton rat lung tissue transcripts were assigned to 12,211 unique UniProt genes, which were then utilized to profile the host immune response after respiratory syncytial virus infection. Differential expression analysis showed up-regulation of host genes involved in cellular functions including defense responses to viral infection and immune system processes. [Sci Rep] Full Article Stimulation of human PBMC with A. fumigatus, A. flavus or A. terreus conidia revealed that in contrast to conventional CD4+ and CD8+ T cells, mucosal associated invariant T cells (MAIT) cells responded already after four hours of co-incubation with upregulation of CD69. [Eur J Immunol] Abstract PBMCs were collected from 20 transplant recipients at onset of human cytomegalovirus viremia and four-weeks post. Scientists utilized mass cytometry to perform in-depth characterization of cell-surface and intracellular CD8+ T cell markers and to compare frequencies of these cells between groups. [Transplantation] Abstract The authors studied mouse cytomegalovirus (CMV) in IL-27 receptor deficient animals to assess the role of IL-27 in regulating CMV immunity. They found that IL-27 enhanced the number of antiviral CD4 T cells upon infection. [PLoS One] Full Article Disruption of Glial Cell Development by Zika Virus Contributes to Severe Microcephalic Newborn Mice A single intraperitoneal injection of pregnant mice with a human monoclonal neutralizing antibody provides full protection against Zika virus infection and its associated damages in the developing fetuses. [Cell Discov] Full Article Investigators generated three adenovirus-vectored vaccines carrying envelope (E) (Ad2-E), or premembrane/membrane (prM/M) with E (Ad2-prME), or NS1 in addition to prM/M with E (Ad2-prME-NS1). Ad2-prME induced higher neutralizing antibody response to Zika virus than Ad2-E, suggesting prM/M is important for the folding of immunogenic E. [NPJ Vaccines] Full Article Subscribe to our sister publications: Human Immunology News & Immune Regulation News. | |
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REVIEWSCorrelates of Vaccine-Induced Protective Immunity against Ebola Virus Disease A systems biology approach, integrating clinical, immunological, transcriptomic and metabolomic data from pre-clinical and clinical vaccine studies, together with data from disease survivors, will be instrumental to identify Ebola vaccine correlates of protection. The information generated for the rVSVΔG-ZEBOV-GP vaccine may also help identify the correlates of protection of the other Ebola vaccine candidates. [Semin Immunol] Abstract Visit our reviews page to see a complete list of reviews in the immunology of infectious disease research field. | |
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INDUSTRY NEWSCytoDyn Inc. announced clearance from the independent Institutional Review Board overseeing its CD03 Phase III investigative monotherapy trial to increase the weekly PRO 140 dose from 525 mg to 700 mg for newly enrolled patients. [CytoDyn Inc.] Press Release SomaGenics Awarded Multi-Year Funding for Hepatitis Delta Virus Therapeutic Program SomaGenics, Inc. announced the award of a three-year, $2.9 million NIH grant in support of its Hepatitis Delta Virus therapeutic program under Principal Investigator and SomaGenics CEO Brian H. Johnston, Ph.D. [SomaGenics, Inc. (PR Newswire Association LLC.)] Press Release | |
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POLICY NEWSChinese Vaccine Scandal Unlikely to Dent Childhood Immunization Rates Problems with two Chinese-made vaccines — one of which was distributed to clinics and possibly injected into hundreds of thousands of children — have led to arrests and made international headlines. But researchers who study vaccination in China don’t expect a major effect on the country’s high immunization rates. [Nature News] Editorial Trump’s Pick to Head White House Science Office Gets Good Reviews The long wait for a White House science adviser is over. President Donald Trump announced that he intends to nominate meteorologist Kelvin Droegemeier, a university administrator and former vice-chair of the governing board of the U.S. National Science Foundation, to be director of the White House Office of Science and Technology Policy. [ScienceInsider] Editorial Series of Ethical Stumbles Tests NIH’s Reliance on Private Sector for Research Funding NIH officials told STAT the agency is completing a plan to ensure better ethical compliance and better delineate the actual process for private-sector collaboration. The officials said the plan will be presented to an advisory committee in December. [STAT News] Editorial
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EVENTSNEW International Conference on Emerging Infectious Diseases 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW PhD Student – Virology (University Hospital of Münster) PhD Student/Postdoctoral Position – Infection and Cancer Immunology (Heinrich-Heine University) Postdoctoral Fellow – HIV Transmission and Pathogenesis (University of California, San Francisco) Postdoctoral Fellow/Assistant Professor – Host-Pathogen Interaction (Utrecht University) Research Assistant/Associate – Respiratory Viral Infections (University of Glasgow) Research Assistant/Associate – Hepatitis C (University of Glasgow) Postdoctoral Research Fellow and PhD Positions – HIV Immunology (McGill University Health Centre) Postdoctoral Fellow – Monoclonal Antibody and Viral Vaccine (SRI Employment) Faculty Positions – Infectious Disease Research (Institut Pasteur of Shanghai) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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