Immunology of Infectious Disease News 6.34 August 29, 2018 | |
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TOP STORYA Multi-Cohort Study of the Immune Factors Associated with M. tuberculosis Infection Outcomes Using high-dimensional mass cytometry analyses and functional assays of a cohort of South African adolescents, scientists showed that latent tuberculosis was associated with enhanced cytotoxic responses, which were mostly mediated by CD16 and natural killer cells, and continuous inflammation coupled with immune deviations in both T and B cell compartments. [Nature] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)The authors found that γδ T cells protected neonatal mice against mortality during influenza infection. γδ T cell deficiency did not alter viral clearance or interferon-γ production. [Immunity] Abstract | Press Release | Graphical Abstract Neutralizing Antibodies Inhibit Chikungunya Virus Budding at the Plasma Membrane Researchers describe a mechanism by which neutralizing antibodies inhibit chikungunya virus, the most common alphavirus infecting humans, by preventing virus budding from infected human cells and activating IgG-specific Fcγ receptors. [Cell Host Microbe] Abstract | Graphical Abstract Alveolar Macrophages Provide an Early Mycobacterium tuberculosis Niche and Initiate Dissemination Using a murine infection model, the authors revealed that early, productive M. tuberculosis (Mtb) infection occured almost exclusively within airway-resident alveolar macrophages (AMs). Thereafter Mtb-infected, but not uninfected, AMs localized to the lung interstitium through mechanisms requiring an intact Mtb ESX-1 secretion system. [Cell Host Microbe] Abstract | Graphical Abstract Researchers showed that robust cellular innate immune responses arising early in the blood and tissues in response to Zika virus infection are significantly stronger in males and correlate with increased viral persistence. [Nat Commun] Full Article HIV-1 Intron-Containing RNA Expression Induces Innate Immune Activation and T Cell Dysfunction Investigators showed Rev-CRM1-dependent nuclear export and peripheral membrane association of intron-containing HIV-1 RNA, independent of primary viral sequence or viral protein expression, was subject to sensing and signaling via MAVS, resulting in type I interferon-dependent pro-inflammatory responses in macrophages. [Nat Commun] Full Article | Press Release Researchers demonstrated that NLRC3 deficiency promoted the activation, proliferation, and cytokine production of CD4+ T cells via negatively regulating the NF-κB and MEK-ERK signaling pathways. [PLoS Pathog] Full Article An Adult Zebrafish Model Reveals that Mucormycosis Induces Apoptosis of Infected Macrophages Investigators developed an adult zebrafish model of Mucor circinelloides infection which confirmed the link between sporangiospore size and virulence. Transcriptomic studies revealed a local, strong inflammatory response of the host elicited after sporangiospore germination and mycelial tissue invasion, while avirulent and UV-killed sporangiospores failed to induce inflammation and were rapidly cleared. [Sci Rep] Full Article Scientists demonstrated that alphavirus-based DNA-launched self-replicating RNA replicon vaccines encoding either the glycoprotein (GP) gene or co-expressing the GP and VP40 genes of Sudan or Zaire Ebolavirus are immunogenic in mice inducing both binding and neutralizing antibodies as well as CD8 T cell responses. [Sci Rep] Full Article A Plasmodium berghei Sporozoite-Based Vaccination Platform against Human Malaria The authors describe a novel whole-sporozoite malaria vaccine that employs transgenic sporozoites of rodent P. berghei (Pf) parasites as cross-species immunizing agents and as platforms for expression and delivery of Pf circumsporozoite protein. [npj Vaccines] Full Article Subscribe to our sister publications: Human Immunology News & Immune Regulation News. | |
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REVIEWSEffects of Mycoplasma Infection on the Host Organism Response via p53/NF-κB Signaling Scientists summarize the information known to date on the role of mycoplasmas in the regulation of the host immune response and their functional interactions with p53. [J Cell Physiol] Abstract Visit our reviews page to see a complete list of reviews in the immunology of infectious disease research field. | |
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INDUSTRY NEWSGeoVax and PharmaJet to Collaborate on Development of Needle-Free Vaccine for Zika Virus GeoVax Labs, Inc. announced that it is collaborating with PharmaJet, Inc. on the evaluation of PharmaJet’s needle-free injection system for administration of GeoVax’s Zika vaccine. [GeoVax Labs, Inc.] Press Release Theratechnologies Files Marketing Authorization Application for Trogarzo™ in Europe Theratechnologies Inc. announced that the application for marketing authorization of Trogarzo™ was filed with the European Medicines Agency through its centralized procedure. Theratechnologies seeks to obtain approval for ibalizumab for the treatment of multidrug resistant HIV-1 in the European Union. [Theratechnologies Inc.] Press Release | |
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POLICY NEWSExperts Call for Reversing the Decision to Deny the Ebola Vaccine to Pregnant Women The exclusion of pregnant and lactating women from an effort to vaccinate people exposed to the Ebola virus in the current outbreak is wrong, indefensible, and should be reversed, three public health experts wrote in an opinion article. [STAT News] Editorial Long shrouded in secrecy, the contents of peer review are coming into the open. In the past decade, outlets such as eLife, F1000Research, Royal Society Open Science, Annals of Anatomy, Nature Communications, PeerJ and EMBO Press have begun to publish referee reports. [Nature Comment] Editorial
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EVENTSNEW 29th European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW PhD Positions – Infection Biology and Immunology (ZIBI Graduate School Berlin) Postdoctoral Scholar – Hepatitis B Infection (The Pennsylvania State University College of Medicine) Postdoctoral Scientist – Infection and Immunity (Charite – Universitatsmedizin Berlin) PhD Student – Virology (University Hospital of Münster) PhD Student/Postdoctoral Position – Infection and Cancer Immunology (Heinrich-Heine University) Postdoctoral Fellow – HIV Transmission and Pathogenesis (University of California, San Francisco) Research Assistant/Associate – Hepatitis C (University of Glasgow) Faculty Positions – Infectious Disease Research (Institut Pasteur of Shanghai) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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