Immunology of Infectious Disease News 6.40 October 10, 2018 | |
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TOP STORYScientists showed in untreated SIV-infected rhesus macaques (RMs) that innate lymphoid cell 3s are lost rapidly in mesenteric lymph nodes, yet preserved in SIV+ RMs with pharmacologic or natural control of viremia. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Bacterial Coinfection Restrains Antiviral CD8 T-Cell Response via LPS-Induced Inhibitory NK Cells Investigators showed that in mice, systemic coinfection with E. coli suppresses the lymphocytic choriomeningitis virus-specific cytotoxic T-lymphocyte response and virus elimination in a NK cell- and TLR2/4-dependent manner. [Nat Commun] Full Article Prior studies discovered a role for protective innate memory against recurrent methicillin-resistant S. aureus skin and skin structure infection (SSSI). In the present study, the dynamics and mechanisms of this response were explored in recurrent SSSI in WT mice. [Proc Natl Acad Sci USA] Abstract Microvesicles from Malaria-Infected Red Blood Cells Activate Natural Killer Cells via MDA5 Pathway The authors compared transcriptional profiles of responding and non-responding natural killer cells following exposure to Plasmodium-infected red blood cells and identified MDA5, a RIG-I-like receptor involved in sensing cytosolic RNAs, to be differentially expressed. [PLoS Pathog] Full Article | Press Release Researchers investigated the effects of high mobility group box 1 (HMGB1) on cytokine secretion, as well as the involvement of NF-κB and TLR4 pathways in respiratory syncytial virus-induced HMGB1 release in human airway epithelial cells and its proinflammatory effects on several human primary immune cells. [J Immunol] Abstract Friend Retrovirus Infection Induces the Development of Memory-Like Natural Killer Cells Scientists showed that Friend retrovirus infection of mice induced a population of phenotypically memory-like NK cells at 28 days post infection. [Retrovirology] Full Article In order to understand the role of dengue virus specific T cell responses that associate with protection, investigators studied their frequency and phenotype in relation to clinical disease severity and resolution of viremia in a large cohort of patients with varying severity of acute dengue infection. [PLoS Negl Trop Dis] Full Article The Probacterial Effect of Type I Interferon Signaling Requires Its Own Negative Regulator USP18 Researchers showed that Usp18, an interferon-stimulated gene that negatively regulates type I interferon (IFN-I) signaling, was primarily responsible for the deleterious effect of IFN-I signaling during infection of mice with Listeria monocytogenes or Staphylococcus aureus. [Sci Immunol] Full Article | Press Release Scientists recruited a cohort living in the same household with an active tuberculosis case and examined the abundance and functional phenotypes of three innate T cell populations reactive to M. tuberculosis: γδ T, invariant NK T, and mucosal-associated invariant T cells. [JCI Insight] Full Article Subscribe to our sister publications: Human Immunology News & Immune Regulation News. | |
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REVIEWSDengue Virus and the Host Innate Immune Response The authors focus on the innate immune response to Dengue virus infection and the virus evasion of the innate immune system by escaping recognition or inhibiting the production of an antiviral state. [Emerg Microbes Infect] Full Article Visit our reviews page to see a complete list of reviews in the immunology of infectious disease research field. | |
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INDUSTRY NEWSMassachusetts General Hospital announced that it will take part in an international multi-center trial evaluating ZMapp™, an experimental treatment consisting of three antibodies to treat Ebola Virus Disease. [Massachusetts General Hospital] Press Release UM Earns $10 Million Contract to Develop Universal Flu Vaccine The National Institutes of Health have awarded a $10 million contract to the University of Montana to develop a new universal flu vaccine. [University of Montana] Press Release FDA Approves Expanded Use of Gardasil 9 to Include Individuals 27 through 45 Years Old The FDA approved a supplemental application for Gardasil 9 expanding the approved use of the vaccine to include women and men aged 27 through 45 years. [The Food and Drug Administration] Press Release Valneva Receives FDA Approval for Accelerated Vaccine Dosing Schedule for IXIARO® Valneva USA announced FDA approval of an accelerated dosing regimen for IXIARO®, the only vaccine approved in the United States indicated for protection against disease caused by Japanese encephalitis virus. [Valneva USA] Download Press Release | |
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POLICY NEWSMajor Publishers File Second Lawsuit against ResearchGate ResearchGate, a popular networking platform where scientists can post their published work, has a complicated relationship with academic publishers. A number of them have accused the site of illicitly disseminating copyrighted work, and two of these—Elsevier and the American Chemical Society—filed a lawsuit in Germany last year to try to force ResearchGate to change its practices. [The Scientist] Editorial Ghost Authorship Haunts Industry-Funded Clinical Trials An analysis of industry-funded clinical trials has found that drug companies are often heavily involved in research — but are not always transparent about it. [Nature News] Editorial Questions about Funding and Purpose Loom over a Foundation Congress Created to Help the FDA The Reagan-Udall Foundation for the FDA is supposed to act as a liaison between the FDA itself and drug companies, researchers, nonprofits, or other businesses with regulated products who might want to support a project to make the agency’s job easier. It has raised just under $15 million during its first decade, according to the foundation. [STAT News] Editorial
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EVENTSNEW Autumn Immunology Conference 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Innate Immunity, Virology (Technical University of Munich) NEW Research Fellow – Cellular Immunology (A*STAR) Research Technologist – Immunology (STEMCELL Technologies Inc.) Research Fellow – Immunology (Dana-Farber Cancer Institute) Assistant Professor – Immunology (Ragon Institute of MGH, MIT and Harvard) Associate/Full Specialist – Host-Pathogen Interactions (University of California, San Francisco) Graduate Training Program – RNA & Infection (Helmholtz Centre for Infection Research) Postdoctoral Scholar – Hepatitis B Infection (The Pennsylvania State University College of Medicine) Postdoctoral Scientist – Infection and Immunity (Charite – Universitatsmedizin Berlin) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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