Immunology of Infectious Disease News 7.39 October 8, 2019 | |
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TOP STORYPolyclonal and Convergent Antibody Response to Ebola Virus Vaccine rVSV-ZEBOV Researchers examined the humoral immune response in a subset of human volunteers enrolled in a Phase I recombinant vesicular stomatitis virus-Zaire Ebola virus (rVSV-ZEBOV) vaccination trial by performing comprehensive single B cell and electron microscopy structure analyses. [Nat Med] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)CD103hi Treg Cells Constrain Lung Fibrosis Induced by CD103lo Tissue-Resident Pathogenic CD4 T Cells Scientists found that CD69hiCD103lo CD4+ tissue-resident memory T cells produced effector cytokines and promoted the inflammation and fibrotic responses induced by chronic exposure to Aspergillus fumigatus. [Nat Immunol] Abstract House Dust Mites Activate Nociceptor-Mast Cell Clusters to Drive Type 2 Skin Inflammation Investigators found that house dust mites with cysteine protease activity directly activated peptidergic nociceptors, which were neuropeptide-producing nociceptive sensory neurons that expressed the ion channel TRPV1 and Tac1, the gene encoding the precursor for the neuropeptide substance P. [Nat Immunol] Abstract Glycan-Dependent HIV-Specific Neutralizing Antibodies Bind to Cells of Uninfected Individuals Scientists showed that certain glycan-dependent broadly neutralizing antibodies, such as PGT121 and PGT151, bound to B, activated T, and natural killer cells of HIV-infected and -uninfected individuals. [J Clin Invest] Full Article The authors demonstrated through the use of interleukin-22 (IL-22)BP-knockout mice that a pro-IL-22 environment reduced pulmonary inflammation during H1N1 infection and protected the lung by promoting tight junction formation. [Mucosal Immunol] Abstract Investigators report that a subset of CD4+ T cells, characterized by CD161 expression on the surface, was highly permissive for HIV-1 infection. These cells possessed a significantly higher survival and proliferative capacity than their CD161-negative counterparts. [MBio] Full Article Effect of Seasonal Malaria Chemoprevention on Immune Markers of Exhaustion and Regulation The impact of seasonal malaria chemoprevention on malaria-induced immune dysfunction, as measured by markers associated with exhaustion and regulatory T cells, was explored by flow cytometry. [J Infect Dis] Abstract Researchers revealed that GM-CSF and IL-3 were produced during malaria infections, initially from IgM+ and then from IgG+ B1b B cell plasmablasts, which may represent important emergency cellular sources of these cytokines. [Infect Immun] Abstract In chronic hepatitis B patients under NUC, TG1050 exhibited a good safety profile and was capable to induce HBV-specific cellular immune response. [Hum Vaccin Immunother] Full Article The authors utilized a murine immunization and challenge model to characterize the efficacy of intranasal immunization with DTaP vaccine or DTaP vaccine supplemented with curdlan, a known Th1/Th17 promoting adjuvant. [npj Vaccines] Full Article Subscribe to our sister publications: Human Immunology News & Immune Regulation News. | |
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REVIEWST Cell-Based Strategies for HIV-1 Vaccines Scientists outline some encouraging findings from T-cell vaccine studies, and directly compare key features of some T-cell vaccine candidates currently in the clinical pipeline. [Hum Vaccin Immunother] Abstract Visit our reviews page to see a complete list of reviews in the immunology of infectious disease research field. | |
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INDUSTRY NEWSJohnson & Johnson announced it has committed to ensuring more than $500 million is dedicated to world class research & development and delivery programs over the next four years to accelerate global efforts to eliminate HIV and tuberculosis by 2030. [Johnson & Johnson] Press Release Prokarium Secures £4.6M from Wellcome to Fund the Clinical Development of Its Lead Vaccine Program Prokarium announced it has received an investment of £4.59 million from Wellcome to fund two clinical trials of its lead program, Entervax™, a bivalent vaccine against enteric fever. [Prokarium (Business Wire, Inc.)] Press Release Arbutus Biopharma Corporation announced its decision to discontinue the clinical development of AB-506, an oral capsid inhibitor. AB-506 was in a Phase Ia/Ib clinical trial for the treatment of chronic hepatitis B. [Arbutus Biopharma Corporation] Press Release Bavarian Nordic Announces Initiation of Phase I Clinical Trial of Equine Encephalitis Virus Vaccine Bavarian Nordic A/S announced the initiation of the first-in-human trial of MVA-BN® WEV, a prophylactic vaccine candidate against the equine encephalitis virus – a rare, but potentially deadly illness. [Bavarian Nordic A/S] Press Release Matinas BioPharma Holdings, Inc. announced that the FDA has granted orphan drug designation to MAT2203, Matinas’ proprietary oral amphotericin B product, for the treatment of cryptococcosis, a life-threatening fungal infection most commonly observed in immunocompromised individuals. [Matinas BioPharma Holdings, Inc.] Press Release | |
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POLICY NEWSLarge Numbers of Pregnant Women Not Getting Key Vaccines, CDC Says A significant percentage of pregnant women are not getting a pair of critically important vaccines despite persistent efforts by public health officials to encourage immunizations, according to new data from the Centers for Disease Control and Prevention. [STAT News] Editorial Biologists Who Decoded How Cells Sense Oxygen Win Medicine Nobel A trio of researchers has won the 2019 Nobel Prize in Physiology or Medicine for describing how cells sense and respond to changing oxygen levels by switching genes on and off — a discovery that has been key in understanding human diseases such as cancer and anemia. [Nature News] Editorial
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EVENTSNEW Precision Health: Molecular Basis, Technology and Digital Health Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Associate – Lung Inflammation (The University of Georgia) Research Associate – Immune Cell Culture (STEMCELL Technologies Inc.) Senior Lecturer/Associate Professor – Virology (The University of Melbourne) Postdoctoral Scientist – Flavivirus Infection (Pasteur Institute of Cambodia) Assistant/Associate Professor – Immunology (University of Massachusetts) Faculty Position – Life Sciences (University of Michigan) Assistant Professor – Microbiology and Immunology (Stanford University School of Medicine) Postdoctoral Fellowship – Respiratory Pathogens (Massachusetts General Hospital) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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