Immunology of Infectious Disease News 7.49 December 18, 2019 | |
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TOP STORYThe authors report screening commercial kinase inhibitors for antibacterial activity and found the anticancer drug sorafenib as major hit that effectively kills methicillin-resistant Staphylococcus aureus strains. [Nat Chem] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists demonstrated that SteE converted both the amino acid and substrate specificity of the host pleiotropic serine/threonine kinase GSK3. SteE itself was a substrate of GSK3, and phosphorylation of SteE was required for its activity. [Cell Host Microbe] Full Article | Graphical Abstract Researchers showed that the murine cytomegalovirus M45 protein induced the degradation of two cellular signalling proteins, the nuclear factor κ-light-chain-enhancer of activated B cells essential modulator (NEMO) and the receptor-interacting protein kinase 1 (RIPK1), via a different mechanism: it induced their sequestration as insoluble protein aggregates and subsequently facilitated their degradation by autophagy. [Nat Microbiol] Abstract Maternal Vaccination and Protective Immunity against Zika Virus Vertical Transmission The authors report maternal vaccination using a live-attenuated Zika virus (ZIKV) vaccine (3ʹUTR-∆10-LAV) in a pregnant mouse model. Maternal immunization with 3ʹUTR-∆10-LAV did not cause any adverse effects on pregnancy, fetal development, or offspring behavior. [Nat Commun] Full Article Investigators proposed a mechanism with which passive immunization could alter the humoral response. Antigen-specific B cells evolved and got selected in germinal centers (GCs) on the basis of their ability to acquire antigen from antibody-antigen complexes presented in GCs. [Cell Rep] Full Article | Graphical Abstract To evaluate the ability of respiratory syncytial virus (RSV)-specific neutralizing antibodies to prevent memory CD8 T cell-mediated immunopathology, mice with high-magnitude memory CD8 T cell responses were treated with neutralizing antibodies prior to RSV challenge. [Mucosal Immunol] Full Article Efficient and Robust NK-Cell Transduction with Baboon Envelope Pseudotyped Lentivector Transduction with baboon envelope pseudotyped lentiviral vectors encoding for CAR-CD22 resulted in robust CAR-expression on 38.3 ± 23.8% of NK-cell activation and expansion system cells, leading to specific killing of NK-resistant pre-B-ALL-RS4;11 cell line. [Front Immunol] Full Article Immunity to Influenza Is Dependent on MHC II Polymorphism: Study with 2 HLA Transgenic Strains Researchers infected autoimmune-susceptible DRB1*0401.AEo and non-susceptible *0402.AEo mice with H1N1 influenza and determined clearance and protective immunity to H3N2 virus. [Sci Rep] Full Article Investigators tested the idea of whether peptide-major histocompatibility complexes could directly be captured from cell lysates, including cancer cells using affinity beads, and used to initiate T cell responses. [Sci Rep] Full Article Monocytes Undergo Multi-Step Differentiation in Mice during Oral Infection by Toxoplasma gondii Scientists evaluated the differentiation process that occurs in Ly6Chi monocytes during oral infection by Toxoplasma gondii. Flow cytometry and single-cell analysis revealed distinct activation status and gene expression profiles in the bone marrow, the spleen and the lamina propria of infected mice. [Commun Biol] Full Article Subscribe to our sister publications: Human Immunology News & Immune Regulation News. | |
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REVIEWSB Cell Memory: Building Two Walls of Protection against Pathogens Researchers describe the two-phase process by which antigen drives the generation of long-lived plasma cells and memory B cells and highlight the challenges for successful vaccine development in each phase. [Nat Rev Immunol] Abstract You Shall Not Pass: Memory CD8 T Cells in Liver-Stage Malaria Memory CD8 T cell anatomic localization and expression of transcription factors, homing receptors, and signaling molecules appear to play integral roles in protective immunity to liver-stage malaria. [Trends Parasitol] Abstract Visit our reviews page to see a complete list of reviews in the immunology of infectious disease research field. | |
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INDUSTRY NEWS$1.3 Million to Eliminate Parasitic Worms Researchers from Australian National University have been awarded $1.3 million by the National Health and Medical Research Council e-Asia Joint Research Program. The team will work toward eliminating parasitic worms and associated liver cancer in communities of the Lower Mekong Basin. [Australian National University] Press Release First Light Diagnostics, Inc. announced the authorization of $4.3 million in additional funding from BARDA in support of First Light’s development of the MultiPath platform, along with diagnostic tests for anthrax and urinary tract infection pathogen identification and culture-free, anti-microbial susceptibility testing. [First Light Diagnostics, Inc.] Press Release Mycovia Pharmaceuticals, Inc. announced it has completed enrollment for its ongoing Phase III ultraVIOLET clinical trial for VT-1161. [Mycovia Pharmaceuticals, Inc.] Press Release | |
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POLICY NEWSChinese Institutes Investigate Pathogen Outbreaks in Lab Workers Two Chinese agriculture research institutions are investigating how more than 100 students and staff became infected with the bacterium Brucella, strains of which are typically found in farm animals but can also trigger potentially fatal complications in people. [Nature News] Editorial NIH Strategic Plan Details Pathway to Achieving Hepatitis B Cure The Strategic Plan for Trans-NIH Research to Cure Hepatitis B focuses on three key research areas. The first priority calls for a better understanding of hepatitis B biology, including the viral and host factors that lead to disease, immunity, reactivation and transmission, as well as the impact of co-infections with other hepatitis viruses and HIV. An improved understanding of these factors and the HBV lifecycle is essential to developing a cure. [National Institutes of Health] Editorial
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EVENTSNEW Translational Research in Viral Hepatitis: Addressing the Gaps for Cure Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellowship – Infectious Disease (Brigham and Women’s Hospital) NEW PhD & MD/PhD Positions – Immunology & Infectious Diseases (Research Training Group 1949) Postdoctoral Research Fellow – HIV (Fred Hutchinson Cancer Research Center) Research Fellow – Immune Response to Tuberculosis (University College London) Senior Lecturer – Infectious Disease and Microbiomes (University of Liverpool) Postdoctoral Fellow – Cerebral Malaria (European Molecular Biology Laboratory) Postdoctoral Positions – HIV (University of New South Wales) Faculty Position – Infectious Disease Research (Tsinghua University School of Medicine) Postdoctoral Associates – Virology and Vaccine Development (University of Minnesota) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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