Immunology of Infectious Disease News 8.08 March 4, 2020 | |
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TOP STORYResearchers designed a ferritin nanoparticle vaccine that could deliver preS1 to specific myeloid cells, including SIGNR1+ dendritic cells and lymphatic sinus-associated SIGNR1+ macrophages. [Nat Nanotechnol] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)HIV-1 Uncoats in the Nucleus Near Sites of Integration The authors developed methods to analyze HIV-1 uncoating by direct labeling of capsid protein with GFP and identified infectious virions by tracking viral cores in living infected cells through viral DNA integration and proviral DNA transcription. [Proc Natl Acad Sci USA] Full Article Viral Infection Triggers Interferon-Induced Expulsion of Live Cryptococcus neoformans by Macrophages Investigators showed that cryptococcal vomocytosis from macrophages was strongly enhanced by viral coinfection, without altering phagocytosis or intracellular proliferation of the fungus. [PLoS Pathog] Full Article Scientists showed that viral protein U (Vpu)s from several simian immunodeficiency viruses (SIVs) infecting wild chimpanzees, gorillas or monkeys isolates failed to antagonize human BST-2. Only Vpu from an SIVgsn isolate was able to antagonize human BST-2 as well as BST-2 of its natural host the greater spot-nosed monkey. [J Virol] Abstract | Editorial A mechanism-based model was built to describe M. tuberculosis H37Rv infection over time in BALB/c and athymic nude mice, which consisted of bacterial replication, bacterial death, and adaptive immune effects. [Antimicrob Agents Chemother] Full Article Depletion of triggering receptor expressed on myeloid cells 1 (TREM-1) in enterovirus A71-infected peripheral blood mononuclear cells with peptide LP17 resulted in decreased levels of pro-inflammatory genes for moderate and severe isolates. [Sci Rep] Full Article Leishmania donovani Infection Induces Differential miRNA Expression in CD4+ T Cells Researchers co-cultured mice CD4+ T cells with L. donovani infected and uninfected macrophages for the identification of dysregulated miRNAs in CD4+ T cells by next-generation sequencing. [Sci Rep] Full Article Flow cytometric analyses of lung-recovered cells revealed that pulmonary macrophages were polarized toward an M1-like phenotype during the onset of disease and prior to host death, which correlated with the significant loss of CD31+CD45– endothelial cells and M2-like cells. [PLoS Negl Trop Dis] Full Article The authors investigated the presence of multifunctional CD4+ and CD8+ T cells which expressed IFNγ, IL10 and TNF, or its combinations during dengue infection. [Immunology] Abstract Positive Selection of a Serine Residue in Bat IRF3 Confers Enhanced Antiviral Protection Researchers demonstrated that a serine residue in IRF3 was positively selected for in multiple bat species. Replacing the serine residue in bat IRF3 with the human leucine residue decreased antiviral protection in bat cells while the addition of this serine residue in human IRF3 significantly enhanced antiviral protection in human cells. [iScience] Abstract | Full Article | Graphical Abstract Subscribe to our sister publications: Human Immunology News & Immune Regulation News. | |
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REVIEWSRegulatory T Cells and T Helper 17 Cells in Viral Infection Studies have shown that regulatory T cells and T helper 17 cells have rather complex interplays in viral infection. The authors take respiratory syncytial virus, hepatitis B virus/hepatitis C virus and human immunodeficiency virus infections as examples to discuss these interplays and their impacts on disease progression in viral infection. [Scand J Immunol] Abstract Visit our reviews page to see a complete list of reviews in the immunology of infectious disease research field. | |
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INDUSTRY NEWSDynavax Technologies Corporation announced it is collaborating with the University of Queensland as part of a CEPI initiative to develop a vaccine to prevent COVID-19. Dynavax is providing technical expertise and the company’s proprietary toll-like receptor 9 agonist adjuvant, CpG 1018, to support this initiative. [Dynavax Technologies Corporation] Press Release Iktos and SRI International announced that the companies have entered into a collaboration agreement designed to accelerate discovery and development of novel anti-viral therapies. Under the collaboration, Iktos’ generative modeling technology will be combined with SRI’s SynFini™, a fully automated end-to-end synthetic chemistry system, to design novel, optimized compounds and accelerate the identification of drug candidates to treat multiple viruses, including influenza and the Wuhan coronavirus. [Iktos (Business Wire, Inc.)] Press Release Vir Biotechnology, Inc. and Alnylam Pharmaceuticals, Inc. announced an expansion of their existing collaboration to include the development and commercialization of RNAi therapeutics targeting SARS-CoV-2, the virus that causes the disease COVID-19. [Vir Biotechnology, Inc.] Press Release Moderna Completes Enrollment of Cytomegalovirus (CMV) Vaccine (mRNA-1647) Phase II Study Moderna, Inc. announced that enrollment is complete for all three dose cohorts of the Phase II dose-confirmation study of its investigational CMV vaccine. [Moderna, Inc.] Press Release Takeda Initiates Development of a Plasma-Derived Therapy for COVID-19 Takeda Pharmaceutical Company Limited shared with members of the United States Congress that it is initiating the development of an anti-SARS-CoV-2 polyclonal hyperimmune globulin to treat high-risk individuals with COVID-19, while also studying whether Takeda’s currently marketed and pipeline products may be effective treatments for infected patients. [Takeda Pharmaceutical Company Limited] Press Release | |
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POLICY NEWSCoronavirus Response: A Focus on Containment Is Still Apt More than 3,000 recorded deaths and 90,000 confirmed infections, and the numbers are still rising. The coronavirus that causes COVID-19 has spread to more than 70 countries, with more nations being affected daily. As new clusters emerge, all eyes are on the World Health Organization. [Nature News] Editorial China Bans Cash Rewards for Publishing Papers Chinese institutions have been told to stop paying researchers bonuses for publishing in journals, as part of a new national policy to cut perverse incentives that encourage scientists to publish lots of papers rather than focus on high-impact work. [Nature News] Editorial
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EVENTSNEW Immunology 2020 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Fellowship – Molecular Infection Biology (UmeÃ¥ University) NEW Postdoctoral Position – Bacterial Gastrointestinal Pathogens (UmeÃ¥ University) NEW Postdoctoral Fellow/Research Scientist – Hepatitis Research (Nationwide Children’s Hospital) Scientist – Immunology (STEMCELL Technologies Inc.) Department Chair – Microbiology and Immunology (Western University) Postdoctoral Researcher – Microtubules in Viral Infection (Northwestern Feinberg School of Medicine) Postdoctoral Fellow – HIV (Massachusetts General Hospital) Postdoctoral Scientist – Tuberculosis Research (Texas Biomedical Research Institute) Research Associate – Immunology (University Hospital of Muenster) Postdoctoral Fellow – Immunology (Harvard T.H. Chan School of Public Health) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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