 | | Vol. 9.00 – 6 January, 2021 |
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| Scientists analyzed multiple compartments of circulating immune memory to SARS-CoV-2 in 254 samples from 188 COVID-19 cases, including 43 samples at ≥ six months post-infection.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers report that the commonly used stabilized S ectodomain construct ‘2P’ was sensitive to cold temperatures, and this cold sensitivity was abrogated in a ‘down’ state-stabilized ectodomain. Their findings will impact structural, functional and vaccine studies that use the SARS-CoV-2 S ectodomain.
[Nature Structural & Molecular Biology] |
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| Using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein, investigators studied the neutralizing antibody response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections.
[Cellular & Molecular Immunology] |
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| Comparisons of skin scarification with intradermal, subcutaneous, or intramuscular routes showed that MVAOVA skin scarification-generated T cells were both more abundant and transcriptionally unique.
[npj Vaccines] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Researchers report a progenitor–progeny relationship between memory-like and terminally exhausted hepatitis C virus (HCV)-specific CD8+ T cells via an intermediate subset.
[Nature Immunology] |
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| Investigators characterized a quorum-sensing anti-activator protein, Aqs1, found in Pseudomonas phage DMS3. They showed that Aqs1 inhibited LasR, the master regulator of quorum sensing, and presented the crystal structure of the Aqs1-LasR complex.
[Molecular Cell] |
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| Scientists investigated the virus binding dynamics to validate the better binding performance of the heteromultivalent moieties as compared to homomultivalent ones.
[Science Advances] |
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| Researchers showed that conformational changes and expansion of iflavirus RNA genomes, which were induced by acidic pH, trigger the opening of iflavirus particles.
[Science Advances] |
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| Investigators used a Caenorhabditis elegans model of Enterohemorrhagic Escherichia coli infection to show that microvillar effacement was mediated by a signalling pathway including mitotic cyclin-dependent kinase 1 and diaphanous-related formin 1.
[Nature Communications] |
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| The authors report that hepatitis B virus (HBV) activated glycolysis to impede retinoic acid-inducible gene I (RIG-I)-induced interferon production. They demonstrated that HBV sequesters MAVS from RIG-I by forming a ternary complex including hexokinase.
[Nature Communications] |
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| An immunogenic protocell comprising hyaluronic acid-polymer membrane decorated with synthetic virus-like particles derived from the functionalization of core-shell polymer nanoparticles with a Toll-like receptor agonist and cell/protocell membrane-binding lectin was fabricated.
[Cell Reports Physical Science] |
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| Human pluripotent stem cell technology has the potential to address key unanswered questions about antiviral immunity in the central nervous system, including emerging questions on the potential CNS tropism of severe acute respiratory syndrome coronavirus 2
[Nature Reviews Immunology] |
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| AstraZeneca’s COVID-19 vaccine has been granted emergency use authorisation in India as well as Argentina, Dominican Republic, El Salvador, Mexico and Morocco for the active immunisation of adults.
[AstraZeneca] |
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| Tiziana Life Sciences plc announceed the completion of its clinical study in Brazil investigating nasally administered Foralumab, its proprietary human monoclonal antibody, either alone or in combination with orally administered dexamethasone in COVID-19 patients.
[Tiziana Life Sciences plc (Globe Newswire, Inc.)] |
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| January 25 – 28, 2021
Virtual |
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| | Karolinska Institutet – Huddinge, Sweden |
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| | University of California Irvine – Irvine, California, United States |
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| | University of Minnesota Medical School – Minneapolis, Minnesota, United States |
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| | Lerner Research Institute, Cleveland Clinic – Cleveland, Ohio, United States |
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| | University of California Irvine – Irvine, California, United States |
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