 | | Vol. 9.07 – 24 February, 2021 |
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| Experiments with 18 pseudotyped viruses showed that the 501Y.V2 variants did not confer increased infectivity in multiple cell types except for murine ACE2-overexpressing cells.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists identified 377 human monoclonal antibodies recognizing the virus spike, and focused mainly on 80 that bound the receptor binding domain.
[Cell] |
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| By single cell sorting 4,277 SARS-CoV-2 spike protein specific memory B cells from 14 COVID-19 survivors, 453 neutralizing antibodies were identified.
[Cell] |
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| Investigators report a biological activity-based modeling approach, in which compound activity profiles established across multiple assays were used as signatures to predict compound activity in other assays or against a new target.
[Nature Biotechnology] |
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| Through experimental coinfection with influenza A virus (IAV) and either pseudotyped or live SARS-CoV-2 virus, scientists found that IAV preinfection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types.
[Cell Research] |
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| Researchers examined longitudinal plasma samples from hospitalized COVID-19 patients with differential clinical outcome.
[Nature Communications] |
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| Scientists showed a comprehensive profile of antibody, B cell and T cell dynamics over time in a cohort of patients who have recovered from mild-moderate COVID-19.
[Nature Communications] |
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| MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
| | The authors investigated the safety and mechanisms of action of Staphylococcus hominis A9, a bacterium isolated from healthy human skin, as a topical therapy for atopic dermatitis.
[Nature Medicine] |
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| Researchers showed that CbpD, the lytic polysaccharide monooxygenases of Pseudomonas aeruginosa, was a chitin-oxidizing virulence factor that promoted survival of the bacterium in human blood.
[Nature Communications] |
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| In mice, epigraph vaccination led to significant cross-reactive antibody and T-cell responses against a diverse panel of swine H3isolates.
[Nature Communications] |
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| Scientists monitored epithelial cell monolayers infected with intracellular bacterial pathogens, Listeria monocytogenes or Rickettsia parkeri, over days.
[Developmental Cell] |
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| The authors queried the diagnostic ability of phenotypic markers on Mycobacterium tuberculosis (Mtb)-specific cytokine-producing immune cell subsets for identifying active tuberculosis.
[Clinical Infectious Diseases] |
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| Investigators generated a multivalent vaccine called TeeVax1, a recombinant protein that consists of a fusion of six T-antigen domains.
[Scientific Reports] |
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| The authors summarize how next-generation RNA sequencing has become a primary technology to study host–microbe interactions with high resolution.
[Nature Reviews Genetics] |
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| Scientists review the current understanding of intestinal tropism of SARS-CoV-2 infection, its impact on mucosal function and immunology and summarize the effect of immune-suppression in patients with inflammatory bowel disease (IBD) on disease outcome of COVID-19
[Mucosal Immunology] |
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| Researchers report the qualification/validation of an alternative qualitative human serum bactericidal activity assay which used endogenous complement (enc-hSBA) present in the vaccinee’s serum.
[npj Vaccines] |
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| Florica Therapeutics, Inc. has been awarded a National Science Foundation Small Business Innovation Research grant for $255,678 to work on the Hypothalamus Stem Cell Exosomes for Treatment of COVID-19 project.
[Florica Therapeutics, Inc. (Businesswire, Inc)] |
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| March 24 – 25, 2021
Virtual |
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| | University of California Merced – Merced, California, United States |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| | Helmholtz Centre for Infection Research – Würzburg, Germany |
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| | NCCR AntiResist – Basel, Switzerland |
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| | UT Health Science Center at Tyler – Tyler, Texas, United States |
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