 | | Vol. 9.13 – 7 April, 2021 |
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| By screening plasma from a cohort of donors from Mali, researchers identified individuals with LILRB1-containing antibodies.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators observed that spike-specific IgG antibody levels and ACE2 antibody binding inhibition responses elicited by a single vaccine dose in individuals with prior SARS-CoV-2 infection were similar to those seen after two doses of vaccine in individuals without prior infection.
[Nature Medicine] |
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| To understand how mutations affect Spike antigenicity, researchers isolated and characterized >100 monoclonal antibodies targeting epitopes on RBD, NTD and S2 from SARS-CoV-2-infected individuals.
[Immunity] |
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| The authors report that high-throughput microfluidic screening of antigen-specific B-cells led to the identification of LY-CoV555, a potent anti-spike neutralizing antibody from a hospitalized, convalescent patient with COVID-19.
[Science Translational Medicine] |
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| Scientists showed a range of T cell assays that differentially captured immune function to characterise SARS-CoV-2 responses.
[Nature Communications] |
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| Activation of cell mediated immunity produced a strong viral antigen specific CD8+ T lymphocyte response.
[Molecular Therapy] |
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| Scientists report that mutations frequently found in the S proteins of SARS-CoV-2 from mink were mostly compatible with efficient entry into human cells and its inhibition by soluble ACE2.
[Cell Reports] |
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| Despite the importance of immunity against neuraminidase (NA), NA content and immunogenicity were neglected in current influenza vaccines. To address this, a recombinant N1/N2 NA vaccine was developed.
[npj Vaccines] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Researchers developed an approach to designing proteins that position antibodies or Fc-fusions on the twofold symmetry axes of regular dihedral and polyhedral architectures.
[Science] |
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| The authors evaluated RSV F-specific B cell responses before and after vaccination in six participants using complementary B cell sequencing methodologies and identified 555 clonal lineages.
[Immunity] |
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| Scientists found that patients with early natural killer cell activation after PEG–IFN-α injection experienced greater liver inflammation, lysis of HBV-infected hepatocytes, and hepatitis B surface antigen decline than those without.
[Science Translational Medicine] |
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| Investigators studied the association between detection of defective viral genomes of the copy-back type and disease severity in three respiratory syncytial virus A-confirmed cohorts.
[Nature Microbiology] |
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| Researchers addressed the role of typhoid toxin in modulation of the host-microbial interaction in health and disease.
[Cell Reports] |
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| To eliminate glycan holes and mimic the glycosylation of native BG505 Env, the authors replaced all 12 NxS sequons on BG505 SOSIP with NxT.
[Cell Reports] |
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| Researchers describe the development of a platform to supplement existing tools of pre-clinical malaria vaccine development, by displaying linear peptides on a virus-like particle
[npj Vaccines] |
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| Scientists propose that SARS-CoV-2 infection induces a process known as immunothrombosis, in which activated neutrophils and monocytes interact with platelets and the coagulation cascade, leading to intravascular clot formation in small and larger vessels.
[Nature Reviews Immunology] |
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| The authors discuss what is known about SARS-CoV-2 in the context of the broad knowledge of influenza virus, highlighting the similarities and differences between the respiratory viruses.
[Nature Reviews Microbiology] |
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| Vir Biotechnology, Inc. announced new preclinical research demonstrating the ability of VIR-7831, the company’s investigational SARS-CoV-2 monoclonal antibody, to maintain its neutralizing activity against a mutation in the receptor binding domain of SARS-CoV-2, called L452R, which is found in the California variant.
[Vir Biotechnology, Inc. (Globe Newswire, Inc.)] |
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| April 28 – 29, 2021
Virtual |
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| | NIH National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States |
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| | The University of Warwick – Coventry, England, United Kingdom |
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| | IPBS-Toulouse – Toulouse, France |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| | University of California Merced – Merced, California, United States |
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