Intestinal Cell News Volume 1.06 | May 1 2015

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    Intestinal Cell News 1.06 May 1, 2015

    Intestinal Cell News

         In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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    TOP STORY
    IL-33 Promotes Colorectal Cancer Tumor-Growing Environment
    Researchers have unlocked new clues about how the colorectal cancer tumor microenvironment is formed and regulated. They found that tumor epithelial cells produce interleukin 33 (IL-33), an important mediator of normal immune and wound healing responses during infection in several tissues, to alter the behavior and differentiation of stromal cells. [Press release from Baylor College of Medicine discussing online prepublication in Proc Natl Acad Sci USA] Press Release | Abstract
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    PUBLICATIONS (Ranked by impact factor of the journal)
    INTESTINAL CANCERS & DISEASES

    The Molecular Landscape of Colorectal Cancer Cell Lines Unveils Clinically Actionable Kinase Targets
    The authors described the mutational and gene expression analyses of 151 colorectal cancer (CRC) cell lines. They found that the whole spectrum of CRC molecular and transcriptional subtypes, previously defined in patients, was represented in this cell line compendium. [Nat Commun] Abstract

    Induction of the Intestinal Stem Cell Signature Gene SMOC-2 is Required for L1-Mediated Colon Cancer Progression
    Scientists identified the immunoglobulin family of cell-adhesion receptors member L1 as a β-catenin-TCF target gene preferentially expressed at the invasive edge of human colorectal cancer tissue. [Oncogene] Abstract

    Windpipe Controls Drosophila Intestinal Homeostasis by Regulating JAK/STAT Pathway via Promoting Receptor Endocytosis and Lysosomal Degradation
    Investigators identified windpipe (wdp) as a novel component of the JAK/STAT pathway. They demonstrated that Wdp is positively regulated by JAK/STAT signaling in Drosophila adult intestines. [PLoS Genet] Full Article

    miR-21 and miR-145 Cooperation in Regulation of Colon Cancer Stem Cells
    The authors investigated the role that microRNAs (miRs), specifically miR-21 and miR-145 play in regulating colon cancer stem cells (CSCs). They found the expression of miR-21 was greatly increased and miR-145 decreased in chemo-resistant colon cancer cells that were highly enriched in CSCs. [Mol Cancer] Full Article

    ERBB4 Is Over-Expressed in Human Colon Cancer and Enhances Cellular Transformation
    Researchers report that ERBB4 is over-expressed in human colorectal cancer, and in experimental systems enhanced the survival and growth of cells driven by Ras and/or WNT signaling. [Carcinogenesis] Abstract

    Argininosuccinate Synthetase 1 Suppression and Arginine Restriction Inhibit Cell Migration in Gastric Cancer Cell Lines
    Scientists indicated that the argininosuccinate synthetase 1 (ASS1) protein is required for cell migration in gastric cancer cell lines. [Sci Rep] Full Article

    The Endoplasmic Reticulum Stress Sensor IRE1α in Intestinal Epithelial Cells Is Essential for Protecting against Colitis
    Investigators demonstrated that genetic ablation of Ire1α in intestinal epithelial cells (IECs) led to spontaneous colitis in mice. Deletion of IRE1α in IECs resulted in loss of goblet cells and failure of intestinal epithelial barrier function. [J Biol Chem] Abstract | Full Article

    Epithelial-Specific ETS-1 (ESE1/ELF3) Regulates Apoptosis of Intestinal Epithelial Cells in Ulcerative Colitis via Accelerating NF-κB Activation
    Scientists report that ESE1/ELF3 was over-expressed in intestinal epithelial cells (IECs) of patients with ulcerative colitis. In DSS-induced colitis mouse models, they observed the up-regulation of ESE1/ELF3 accompanied with the elevated levels of IEC apoptotic markers and NF-κB activation indicators in colitis IECs. [Immunol Res] Abstract

    AMP-18 Targets p21 to Maintain Epithelial Homeostasis
    Scientists characterized therapeutic mechanisms and identified molecular targets by which antrum mucosal protein-18 (AMP-18) maintains and restores disrupted epithelial homeostasis in cultured intestinal epithelial cells and a mouse model of inflammatory bowel disease. [PLoS One] Full Article

    INTESTINAL STEM CELL & ORGANOID RESEARCH

    Sequential Cancer Mutations in Cultured Human Intestinal Stem Cells
    Researchers utilized CRISPR/Cas9 technology for targeted gene modification of four of the most commonly mutated colorectal cancer genes (APC, P53, KRAS and SMAD4) in cultured human intestinal stem cells. [Nature] Abstract

    Free wallchart: The Intestinal Crypt

     
    REVIEWS
    Diverse Roles of LPA Signaling in the Intestinal Epithelium
    The authors review current knowledge of the biological roles of lysophosphatidic acid (LPA) signaling in the intestinal tract. [Exp Cell Res] Abstract

    Visit our reviews page to see a complete list of reviews in the intestinal cell research field.

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    INDUSTRY NEWS
    Sanford J. Grossman Charitable Trust Pledges $3 Million to Create Center for Integrative Studies in Inflammatory Bowel Disease at Mount Sinai
    The Sanford J. Grossman Charitable Trust has committed $3 million to establish the Dr. Sanford J. Grossman Center for Integrative Studies in Inflammatory Bowel Disease at the Icahn School of Medicine at Mount Sinai. [Icahn School of Medicine at Mount Sinai] Press Release

    Qu Biologics Opens Clinical Trial Sites in Edmonton and Toronto for Crohn’s Disease Clinical Trial
    Qu Biologics Inc. announced it has opened two new clinical trial sites in Edmonton, Alberta and Toronto, Ontario to enroll participants in its Crohn’s disease clinical trial. [Qu Biologics Inc.] Press Release

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    POLICY NEWS
    National Institutes of Health (United States)

    Food and Drug Administration (United States)

    Center for Biologics Evaluation and Research (United States)

    European Medicines Agency (European Union)

    Medicines and Healthcare Products Regulatory Agency (United Kingdom)

    Therapeutic Goods Administration (Australia)

     
    EVENTS
    NEWGI Homeostasis: The Microbiome and the Barrier, Development & Disease
    August 2-7, 2015
    Steamboat Springs, United States

    NEW Cancer Diagnosis & Therapy Congress
    September 3-4, 2015
    London, United Kingdom

    Visit our events page to see a complete list of events in the intestinal cell research community.

     
    JOB OPPORTUNITIES
    NEW Assistant/Associate Professor – Cardiovascular and Lymphatic Biology (Texas A&M Health Science Center)

    NEW Postdoctoral Position – Genomics or Computational Genomics (Norwegian PSC research center)

    Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

    Postdoctoral Fellow – Stem Cell Homeostasis in Gut Development and Disease (Sickkids Research Institute)

    Postdoc – Physiology (Radboud University Nijmegen Medical Centre)

    Senior Medical Advisor – Inflammation & Immunology (Celgene Corporation)

    Postdoctoral Fellow – Transcriptional Mechanisms of Stomach and Intestinal Stem Cells (Sickkids Research Institute)

    Postdoctoral Position – Functional Role of Intestinal Macrophages (University of Massachusetts Medical School)

    Postdoctoral Positions – Microbiota in Cancer (Mount Sinai School of Medicine)

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