INTESTINAL CANCERS & DISEASES Wnt/β-Catenin Signaling Regulated SATB1 Promotes Colorectal Cancer Tumorigenesis and Progression Using several colorectal cancer cell line models and the APC min mutant zebrafish in vivo model, researchers established that SATB1 is a novel target of Wnt/β-catenin signaling. [Oncogene] Abstract miR-135b- and miR-146b-Dependent Silencing of Calcium-Sensing Receptor Expression in Colorectal Tumors The authors demonstrated that miR-135b and miR-146b target the calcium-sensing receptor and reduced its expression in colorectal tumors, reducing the antiproliferative and prodifferentiating actions of calcium. [Int J Cancer] Abstract Carnosic Acid Inhibits STAT3 Signaling and Induces Apoptosis through Generation of ROS in Human Colon Cancer HCT116 Cells Investigators revealed that carnosic acid (CA) treatment significantly reduced the viability of human colon cancer HCT116, SW480, and HT-29 cells. Treatment with CA induced apoptosis, which was associated with the induction of p53 and Bax, inhibition of Mdm2, Bcl-2, and Bcl-xl expression, activation of caspase-9, and -3, and the cleavage of PARP in HCT116 cells. [Mol Carcinog] Abstract Distinct Roles for Intestinal Epithelial Cell-Specific Hdac1 and Hdac2 in the Regulation of Murine Intestinal Homeostasis To determine the role of Hdac1 and Hdac2 in the regulation of intestinal epithelial cell function and the establishment of the dual knockout phenotype, investigators generated villin-Cre murine models expressing one Hdac1 allele without Hdac2, or one Hdac2 allele without Hdac1. [J Cell Physiol] Abstract Heterogeneity of Subordination of the IL-18/IFN-γ Axis to Caspase-1 among Patients with Crohn’s Disease Scientists showed a correlation between secreted IFN-γ/IL-18 levels, and caspase-1 activation, with inflammation intensity of intestinal Crohn’s disease mucosa explants. [Lab Invest] Abstract Comparing Two Intestinal Porcine Epithelial Cell Lines (IPECs): Morphological Differentiation, Function and Metabolism IPEC-J2 was found to be a morphologically and functionally more differentiated cell line in comparison to IPEC-1. [PLoS One] Full Article Derlin-1 Is Overexpressed in Human Colon Cancer and Promotes Cancer Cell Proliferation Researchers examined Derlin-1 expression in colon cancer cell lines and human tissues and investigated its role in colon cancer. They found that Derlin-1 expression was increased significantly in colon cancer tissues and its overexpression correlated with the tumor differentiation, Dukes stage, invasion, lymph node metastasis, distant metastasis, and poor overall survival. [Mol Cell Biochem] Abstract INTESTINAL STEM CELL & ORGANOID RESEARCH SOX9 Maintains Reserve Stem Cells and Preserves Radio-Resistance in Mouse Small Intestine Scientists performed single-cell analyses to characterize the expression of active and reserve intestinal stem cells markers in Lgr5high cells and Sox9high cells isolated from reporter mice by fluorescence-activated cell sorting. [Gastroenterology] Abstract |