INTESTINAL CANCERS & DISEASES The MAP3K ZAK, a Novel Modulator of ERK-Dependent Migration, Is Upregulated in Colorectal Cancer Scientists showed that both isoforms of ZAK, ZAK-α and ZAK-β are key factors in cancer cell migration. [Oncogene] Abstract Inhibition of Caspases Primes Colon Cancer Cells for 5-Fluorouracil-Induced TNF-α-Dependent Necroptosis Driven by RIP1 Kinase and NF-κB Investigators explored the usage of pan-caspase inhibitors to sensitize resistant colorectal cancer cells for 5-fluorouracil. [Oncogene] Abstract Epithelial IL-1R2 Acts as a Homeostatic Regulator during Remission of Ulcerative Colitis Researchers aimed to identify the endogenous regulatory mechanisms that may promote disease remission. [Mucosal Immunol] Full Article N-Glycosylation Profiling of Colorectal Cancer Cell Lines Reveals Association of Fucosylation with Differentiation and CDX1/Villin mRNA Expression Investigators characterized the N-glycan profiles of 25 different colorectal cancer cell lines, derived from primary tumors and metastatic sites, in order to investigate their potential as glycobiological tumor model systems, and to reveal glycans associated with cell line phenotypes. [Mol Cell Proteomics] Abstract | Full Article H2S, a Novel Gasotransmitter, Involved in Gastric Accommodation Researchers investigated the role of H2S in gastric accommodation using CBS+/− mice, immunohistochemistry, immunoblot, methylene blue assay, intragastric pressure recording and electrical field stimulation. [Sci Rep] Full Article IL-10-Producing CD4+ T Cells Negatively Regulate Fucosylation of Epithelial Cells in the Gut Scientists showed that epithelial fucosylation in the ileum is negatively regulated by IL-10-producing CD4+ T cells. [Sci Rep] Full Article Isolation of Human Colon Stem Cells Using Surface Expression of PTK7 Investigators identified stem cell markers that would allow for purification of human colonic stem cells. [Stem Cell Reports] Full Article Unmethylated CpG Motifs in Toxoplasma gondii DNA Induce TLR9- and IFN-β-Dependent Expression of α-Defensin-5 in Intestinal Epithelial Cells The authors showed that α-defensin-5 is rapidly upregulated in intestinal epithelial cells following intracellular Toll-like receptor 9 (TLR9) activation by unmethylated CpG motifs in DNA from T. gondii. [Parasitology] Abstract INTESTINAL STEM CELL & ORGANOID RESEARCH Radiation-Induced Hyperproliferation of Intestinal Crypts Results in Elevated Genome Instability with Inactive p53-Related Genomic Surveillance The authors determined the genomic surveillance process during crypt hyperproliferation, and its consequential outcome after ionizing radiation. [Life Sci] Abstract |