INTESTINAL CANCERS & DISEASES Cell Nonautonomous Activation of Flavin-Containing Monooxygenase Promotes Longevity and Health Span Stabilization of the hypoxia-inducible factor 1 (HIF-1) increased life span and health span in nematodes through an unknown mechanism. The authors report that neuronal stabilization of HIF-1 mediates these effects in C. elegans through a cell nonautonomous signal to the intestine, which resulted in activation of the xenobiotic detoxification enzyme flavin-containing monooxygenase-2. [Science] Abstract Liver X Receptor Regulates Triglyceride Absorption through Intestinal Downregulation of Scavenger Receptor Class B, Type 1 In Caco-2/TC7 cells and mice, intestinal activation of liver X receptor reduced production of chylomicron by a mechanism dependent on the apical localization of scavenger receptor class B, type 1. [Gastroenterology] Abstract PRMT1-Mediated Methylation of the EGF Receptor Regulates Signaling and Cetuximab Response Scientists determined that methylation at R198 and R200 of the EGFR extracellular domain by protein arginine methyltransferase 1 (PRMT1) enhances binding to EGF and subsequent receptor dimerization and signaling activation. [J Clin Invest] Full Article | Press Release MicroRNA-22 Inhibits Tumor Growth and Metastasis in Gastric Cancer by Directly Targeting MMP14 and Snail Investigators found that the expression of microRNA (miR)-22 was significantly reduced in clinical gastric cancer (GC) tissues compared with paired adjacent normal tissues, and was significantly correlated with a more aggressive phenotype of GC in patients, and low miR-22 expression correlated with poor overall survival. [Cell Death Dis] Full Article Bile Acids Regulate Intestinal Cell Proliferation by Modulating EGFR and FXR Signaling Scientists examined the effects of bile acids on intestinal epithelial cell proliferation and investigated the possible roles for epidermal growth factor receptor (EGFR) and farnesoid X receptor (FXR) in these effects. [Am J Physiol Gastrointest Liver Physiol] Abstract Lgr5 Methylation in Cancer Stem Cell Differentiation and Prognosis-Prediction in Colorectal Cancer Researchers investigated the methylation status within the leucine-rich-repeat-containing G-protein-coupled receptor 5 (lgr5) promoter and evaluated its relationship with cancer stem cells differentiation, prognosis for colorectal cancer, and its clinicopathological features. [PLoS One] Full Article Hcrcn81 Promotes Cell Proliferation through Wnt Signaling Pathway in Colorectal Cancer Scientists investigated the role of hcrcn81 gene in Wnt/β-catenin signaling pathway related to human colorectal cancer. [Med Oncol] Abstract INTESTINAL STEM CELL & ORGANOID RESEARCH Bidirectional Notch Signaling Regulates Drosophila Intestinal Stem Cell Multipotency Investigators found that during enteroendocrine (ee) cell formation, the ee cell marker Prospero localizes to the basal side of dividing intestinal stem cells. [Science] Abstract Agonists of the TRAIL Death Receptor DR5 Sensitize Intestinal Stem Cells to Chemotherapy-Induced Cell Death and Trigger Gastrointestinal Toxicity Researchers showed that the combined administration of the DR5 agonistic monoclonal antibody and chemotherapy to wildtype mice triggered synergistic gastrointestinal toxicities that were associated with the death of Lgr5+ crypt base columnar stem cells in a p53- and DR5-dependent manner. [Cancer Res] Abstract |