INTESTINAL CANCERS & DISEASES The Msi Family of RNA-Binding Proteins Function Redundantly as Intestinal Oncoproteins Scientists demonstrated that MSI1 and MSI2 act as functionally redundant oncoproteins required for the ontogeny of intestinal cancers. [Cell Rep] Full Article | Graphical Abstract Up-Regulation of REG3A in Colorectal Cancer Cells Confers Proliferation and Correlates with Colorectal Cancer Risk Scientists explored the biological function and the underlying molecular mechanism of regenerating islet-derived 3 alpha (REG3A) in colorectal cancer (CRC). REG3A was found elevated in CRC compared with normal tissues. [Oncotarget] Full Article Profiles of microRNA Networks in Intestinal Epithelial Cells in a Mouse Model of Colitis The authors aimed to uncover the regulatory microRNA-target gene relationships that arise differentially in inflamed small- compared with large-intestinal epithelial cells. [Sci Rep] Full Article FAT4 Functions as a Tumor Suppressor in Gastric Cancer by Modulating Wnt/β-Catenin Signaling The authors investigated the role of FAT4 in gastric cancer and examined the underlying molecular mechanisms. FAT4 had a tumor suppressor role mediated by the modulation of Wnt/β-catenin signaling, providing potential novel targets for the treatment of gastric cancer. [Br J Cancer] Abstract Epithelial Sel1L Is Required for the Maintenance of Intestinal Homeostasis The authors showed that the expression of SEL1L and HRD1, the most conserved branch of mammalian ERAD, is significantly reduced in ileal Crohn’s disease. [Mol Biol Cell] Abstract Hes1 Increases the Invasion Ability of Colorectal Cancer Cells via the STAT3-MMP14 Pathway Investigators explored the role of hairy/enhancer of split (HES) in the tumorigenesis of colorectal cancer. Knocking down Hes1 induced colorectal cancer cell senescence and decreased the invasion ability, whereas over-expression of Hes1 increased STAT3 phosphorylation activity and up-regulated MMP14 protein level. [PLoS One] Full Article RhoA Is Associated with Invasion and Poor Prognosis in Colorectal Cancer The authors investigated the functional importance of RhoA using human cell lines as well as 150 colorectal cancer patient-derived samples as it remains unclear whether RhoA functions as either an oncogene or a tumor suppressor in colon cancer. [Int J Oncol] Abstract Permeability of Plumbagin across Human Intestinal Cell In Vitro Researchers investigated the permeability of plumbagin across Caco-2 cell monolayer and its effects on the expression and function of P-glycoprotein. [Arch Pharm Res] Abstract INTESTINAL STEM CELL & ORGANOID RESEARCH Fasting Protects Mice from Lethal DNA Damage by Promoting Small Intestinal Epithelial Stem Cell Survival Scientists demonstrated that fasting preserves small intestinal (SI) architecture by maintaining SI stem cell viability and SI barrier function following exposure to high-dose etoposide. [Proc Natl Acad Sci USA] Abstract |