INTESTINAL CANCERS & DISEASES Adenomatous Polyposis Coli (APC) Regulates miR17-92 Cluster through β-Catenin Pathway in Colorectal Cancer Investigators revealed that miR-17-92 cluster is directly regulated by APC/β-catenin pathway and could be a potential therapeutic target in colon cancers with aberrant APC/β-catenin signaling. [Oncogene] Abstract Dysregulated Lysine Acetyltransferase 2B Promotes Inflammatory Bowel Disease Pathogenesis through Transcriptional Repression of Interleukin-10 Scientists demonstrated a novel epigenetic mechanism of IL-10 dysregulation in inflammatory bowel disease. Down-regulation of lysine acetyltransferase 2B may disrupt the innate and adaptive inflammatory responses due to the suppression of this crucial anti-inflammatory cytokine. [J Crohns Colitis] Abstract Stearoyl-CoA Desaturase-1 Mediated Cell Apoptosis in Colorectal Cancer by Promoting Ceramide Synthesis In vitro study in colorectal cancer cells demonstrated inhibition of stearoyl-CoA desaturase 1 activity promoted apoptosis attributed to mitochondria dysfunctions, upregulation of reaction oxygen species, alteration of mitochondrial transmembrane potential and translocation of mitochondrial protein cytochrome C. [Sci Rep] Full Article Downregulation of CDC27 Inhibits the Proliferation of Colorectal Cancer Cells via the Accumulation of p21Cip1/Waf1 Investigators explored the biological and clinical significance of cell division cycle 27 (CDC27) in colorectal cancer growth and progression and investigated the underlying molecular mechanisms. [Cell Death Dis] Full Article Long Non-Coding RNA AK027294 Involves in the Process of Proliferation, Migration, and Apoptosis of Colorectal Cancer Cells Scientists investigated the differentially expressed long non-coding RNAs in colorectal cancer and its potential biological function. [Tumor Biol] Abstract | Full Article Characterization of HAF-4- and HAF-9-Localizing Organelles as Distinct Organelles in Caenorhabditis elegans Intestinal Cells The authors characterized a subset of the intestinal granules in which HAF-4 and HAF-9 localize on the membrane. HAF-4 and HAF-9 are ATP-binding cassette transporter proteins that are homologous to the mammalian lysosomal peptide transporter associated with antigen processing-like, ABCB9. [BMC Cell Biol] Full Article INTESTINAL STEM CELL & ORGANOID RESEARCH Loss of Survivin in Intestinal Epithelial Progenitor Cells Leads to Mitotic Catastrophe and Breakdown of Gut Immune Homeostasis Scientists showed that Survivin is specifically expressed in transit-amplifying cells and Lgr5+ stem cells. Genetic loss of Survivin in intestinal epithelial cells resulted in destruction of intestinal integrity, mucosal inflammation, and death of the animals. [Cell Rep] Full Article | Graphical Abstract Co-Culture with Intestinal Epithelial Organoids Allows Efficient Expansion and Motility Analysis of Intraepithelial Lymphocytes Researchers aimed at developing a novel co-culture system of intraepithelial lymphocytes with intestinal epithelial cells to investigate dynamic interaction between these two populations of cells in vitro. [J Gastroenterol] Abstract Development of Functional Microfold (M) Cells from Intestinal Stem Cells in Primary Human Enteroids Human intestinal crypts containing intestinal stem cells were cultured and differentiated into an epithelial layer with functional M cells with characteristic morphological and functional properties. [PLoS One] Full Article |