Intestinal Cell News Volume 2.04 | Feb 5 2016

Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet
Scientists demonstrated that the LXR-responsive phospholipid-remodeling enzyme Lpcat3 modulates intestinal fatty acid and cholesterol absorption and is required for survival on a high-fat diet. [Cell Metab]
Abstract | Graphical Abstract

RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer
The authors report that the chromatin-targeting E3 ubiquitin ligase RNF20/RNF40, driving histone H2B monoubiquitylation, modulates inflammation and inflammation-associated cancer in mice and humans. [Cell Rep] Full Article | Graphical Abstract

IGF/STAT3/NANOG/Slug Signaling Axis Simultaneously Controls Epithelial-Mesenchymal Transition and Stemness Maintenance in Colorectal Cancer
The authors identified a small subpopulation of NANOG-positive colorectal cancer cells, and demonstrated that they exhibited characteristics of cancer stem cells and epithelial-mesenchymal transition traits simultaneously. [Stem Cells] Abstract

Role of CD44^high/CD133^high HCT-116 Cells in the Tumorigenesis of Colon Cancer
Scientists aimed to explore cell surface biomarkers related to cancer stem cells and their role in the tumorigenesis of colon cancer. [Oncotarget] Full Article

miR-143 or miR-145 Overexpression Increases Cetuximab-Mediated Antibody-Dependent Cellular Cytotoxicity in Human Colon Cancer Cells
miR-143 and miR-145 are downregulated in colon cancer. Researchers tested the effect of restoring these miRNAs on sensitization to cetuximab in mutant KRAS and wild-type KRAS colon cancer cells. [Oncotarget] Full Article

Inhibition of HSP90 by AUY922 Preferentially Kills Mutant KRAS Colon Cancer Cells by Activating Bim through ER Stress
Researchers report that mutant KRAS colon cancer cells are more susceptible to apoptosis induced by the heat shock protein 90 inhibitor AUY922 than those carrying wild-type KRAS. [Mol Cancer Ther] Abstract

Epigenetic Regulation of E-Cadherin Expression by the Histone Demethylase UTX in Colon Cancer Cells
Investigators identified ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX), a histone demethylase involved in demethylating di- or tri-methylated histone 3 lysine 27, as a positive regulator for the expression of E-cadherin in the colon cancer cell line HCT-116. [Med Oncol] Abstract

INTESTINAL STEM CELL & ORGANOID RESEARCH

Regulation of Stem Cell Proliferation and Cell Fate Specification by Wingless/Wnt Signaling Gradients Enriched at Adult Intestinal Compartment Boundaries
Investigators utilized the Drosophila midgut, a powerful model for intestinal stem cell regulation, to elucidate the mechanisms by which Wingless/Wnt regulates intestinal homeostasis and development. [PLoS Genet] Full Article

Wildtype Adult Stem Cells, unlike Tumor Cells, Are Resistant to Cellular Damages in Drosophila
Scientists found that in the adult Drosophila midgut, intestinal stem cells (ISCs), unlike tumor intestinal cells, are resistant to various cellular damages. Tumor intestinal cells, unlike wildtype ISCs, were easily eliminated by apoptosis. [Dev Biol] Abstract

Visit our reviews page to see a complete list of reviews in the intestinal cell research field.

From our sponsor: Learn how to form and isolate neural rosettes more efficiently. Watch the video.

New Jersey Health Foundation Awards $1 Million to Advance Research throughout NJ
New Jersey Health Foundation has awarded 30 grants totaling more than $1 million for researchers in New Jersey who are working on health-related research that demonstrates exciting potential. [New Jersey Health Foundation (PR Newswire Association LLC.)] Press Release

Spectrum Awards More than $1 Million in Pilot Grants to 30 Projects
Thirty biomedical projects at Stanford have received a total of $1.1 million in research funding through the Spectrum pilot grant program. [Stanford School of Medicine] Press Release

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Visit our events page to see a complete list of events in the intestinal cell research community.

NEW Postdoctoral Position – Tumor Immunology (Medical University of South Carolina)

NEW Research Associate – Autoimmunity (The Scripps Research Institute)

NEW Postdoctoral Fellowship – Immunology (Beth Israel Deaconess Medical Center)

NEW Gastroenterologist – Inflammatory Bowel Disease (Mayo Clinic)

Postdoctoral Associate – Biomedical and Single Cell Genomics (Cornell University)

Faculty Position – Gastrointestinal Physiology (University of Ottawa)

PhD Studentship – Cell Biology (Cologne Graduate School of Ageing Research)

Postdoctoral Fellow – Stem Cell Biology/Genome Engineering (Amgen)

Postdoctoral Position – Gut Inflammation and IBD (University College Cork)

Recruit Top Talent: Reach more than 60,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.